Sitagliptin + Glimepiride + Metformin

Written By Dr. Mayank

Reviewed By Dr. Rajeev Sharma

Last updated 25 Nov 2025 | 09:37 AM (UTC)

Sitagliptin + Glimepiride + Metformin Uses

Sitagliptin+Glimepiride+Metformin is used in the treatment of type 2 diabetes mellitus.

How Sitagliptin + Glimepiride + Metformin works

Sitagliptin + Glimepiride + Metformin is a combination of three antidiabetic medications. Sitagliptin helps to control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood. Glimepiride lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. Metformin decreases the amount of glucose you absorb from your food and the glucose made by the liver. It also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood (blood sugar levels).

Common side effects of Sitagliptin + Glimepiride + Metformin

Hypoglycemia (low blood glucose level), Headache, Nausea, Diarrhea, Abdominal pain, Constipation, Vomiting

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Medicine brands for Sitagliptin + Glimepiride + Metformin

GlimiSAVE

Eris Lifesciences Ltd

Glenmark Pharmaceuticals Ltd

Akumentis Healthcare Ltd

Alteus Biogenics Pvt Ltd

Expert advice for Sitagliptin + Glimepiride + Metformin

Prefer taking Sitagliptin + Glimepiride + Metformin after a meal or with a snack, as this will reduce the chance of an upset stomach.
Sitagliptin + Glimepiride + Metformin may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol or if you delay or miss a meal. Always carry some sugary food or fruit juice with you in case you experience hypoglycemia (low blood sugar) symptoms, such as fatigue, dizziness, cold sweats, tremor, and anxiety.
If you get unusually thirsty, pass urine more frequently, and feel tired, let your doctor know. These are signs that there is too much sugar in your blood and your dose may need adjusting.
Monitor your blood sugar regularly while taking this medicine.
Lifestyle changes like low sugar diet, exercising, losing weight, not smoking, and cutting down on alcohol intake may help this medication work better.