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Istamet 50mg/1000mg Tablet

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Introduction

Istamet 50mg/1000mg Tablet is a combination of two medicines that control high blood sugar levels in people with type 2 diabetes mellitus. This helps prevent serious complications of diabetes such as kidney damage and blindness and may reduce your chance of having a heart attack or stroke.

Istamet 50mg/1000mg Tablet can be prescribed alone or together with other diabetes medications. All diabetes medicines work best when used along with a healthy diet and regular exercise. The dose you are given will depend on your condition, blood sugar levels, and what other medicines you are taking. Taking it with meals helps to reduce the chances of developing an upset stomach.

You should take it regularly, at the same time each day, to get the most benefit and you should not stop unless your doctor recommends it. It is controlling your blood sugar levels and helping to prevent serious complications in the future. It is important to stay on the diet and exercise program recommended by your doctor while taking this medicine. Your lifestyle plays a big part in controlling diabetes.

The most common side effects of taking Istamet 50mg/1000mg Tablet include diarrhea, nausea, vomiting, upset stomach, headache, and sore throat. Low blood sugar level (hypoglycemia) is a possible side effect if you are also taking other diabetes medicines like insulin or sulfonylurea, so you need to know how to recognize and deal with it.

This medicine is not suitable for everyone. Before taking it, you should let your doctor know if you have ever had kidney, liver or heart disease, problems with your pancreas, or if you drink a lot of alcohol. Pregnant or breastfeeding women should also consult their doctor before taking this medicine. Some other medicines can affect this one so tell your doctor about all the medicines you are taking to make sure you are safe. You should try to avoid drinking alcohol as it lowers blood glucose. Your doctor will check your kidney function and blood sugar levels before and during treatment.

Uses of Istamet Tablet

Benefits of Istamet Tablet

In Type 2 diabetes mellitus

Istamet 50mg/1000mg Tablet is a combination of two medicines that work together in different ways to lower your blood glucose levels. Lowering blood glucose levels is an essential part of managing diabetes. If you can control your blood glucose level, your risk of getting any of the serious complications of diabetes such as kidney damage, eye damage, nerve problems, and loss of limbs is also lowered. Additionally, proper control of diabetes can also reduce the risk of heart disease and stroke. Taking this medicine regularly along with proper diet and exercise will help you live a normal, healthy life. You should keep using this medicine for as long as it is prescribed because it is protecting your future health.

Side effects of Istamet Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Istamet

  • Diarrhea
  • Nausea
  • Vomiting
  • Upset stomach
  • Headache
  • Nasal congestion (stuffy nose)
  • Sore throat
  • Respiratory tract infection
  • Hypoglycaemia (low blood sugar level) in combination with insulin or sulphonylurea

How to use Istamet Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Istamet 50mg/1000mg Tablet is to be taken with food.

How Istamet Tablet works

Istamet 50mg/1000mg Tablet is a combination of two antidiabetic medicines: Sitagliptin and Metformin. They help your pancreas produce more insulin, facilitate effective use of insulin by the body, and reduce excess sugar that your liver makes. Together, they provide better control of blood sugar.

Safety Advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Istamet 50mg/1000mg Tablet.
Pregnancy
SAFE IF PRESCRIBED
Istamet 50mg/1000mg Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breastfeeding
SAFE IF PRESCRIBED
Istamet 50mg/1000mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
CAUTION
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Kidney
CAUTION
Istamet 50mg/1000mg Tablet should be used with caution in patients with kidney disease. Dose adjustment of Istamet 50mg/1000mg Tablet may be needed. Please consult your doctor.
Use of Istamet 50mg/1000mg Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Liver
SAFE IF PRESCRIBED
Istamet 50mg/1000mg Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Istamet 50mg/1000mg Tablet may not be needed in these patients. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Istamet 50mg/1000mg Tablet
₹26.07/Tablet
Janumet 50mg/1000mg Tablet
MSD Pharmaceuticals Pvt Ltd
₹26/Tablet
same price
Sepamet-XR 50mg/1000mg Tablet
Taj Pharma India Ltd
₹38.5/Tablet
48% costlier

Quick Tips

  • Take it with food to lower your chance of having an upset stomach.
  • Chances of weight gain and low blood sugar are lesser as compared to other diabetes medicines. 
  • Inform your doctor about your diabetes treatment if you are due to have surgery under a general anaesthetic.
  • Tell your doctor immediately if you experience any deep or rapid breathing, persistent nausea, vomiting, and stomach pain as Istamet 50mg/1000mg Tablet may cause a rare but serious condition called lactic acidosis, which is an excess of lactic acid in the blood.

Fact Box

Habit Forming
No
Therapeutic Class
ANTI DIABETIC

Patient Concerns

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Diabetes mellitus type 2 ,thirst
Dr. Sanjay Bhatt
Physician
A person can control his or her sugar levels by doing regular exercise and walk or regular aerobic exercises at least 30 to 45 minutes per day.MEDICAL NUTRITIONAL THERAPY THAT IS TO MAINTAIN CALORIES INTAKE AS PER BMI .TAKE HELP OF DIABETIC EDUCATOR. VISIT YOUR DOCTOR AND FOLLOW ALL WHAT DOCTOR SUGGESTED.IN TIME ALL ROUTINE INVESTIGATIONS SHOULD BE DONE.you should not treat it as disease but a start of a healthy life.Uncontrolled sugar levels for long time leads to lower limb weakness which is neuropathy and which is followed by foot ulcers and other complications like kidney or heart problems .online prescription is not allowed without seeing pt.so contact doctor nearby for any change or dose adjustment or visit my clinic at gurgaon sector 52 RdCity snergy multi speciality clinic near SRS MARKET
Best medicin for diabetes to me Tell me best medicin for type 2 I am taking Istamet This time my fasting is 238
Dr. Ashwin Porwal
Internal Medicine
ask your treating physician to add another OHA
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FAQs

Q. Can the use of Istamet 50mg/1000mg Tablet lead to Vitamin B12 deficiency?

Yes, the use of Istamet 50mg/1000mg Tablet can cause Vitamin B12 deficiency on long-term use. It interferes with the absorption of Vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems as a result of which the patient can feel tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.

Q. What is Istamet 50mg/1000mg Tablet?

Istamet 50mg/1000mg Tablet is a combination of two medicines: Sitagliptin and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus. It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. Sitagliptin inhibits the enzyme DPP4 and increases the release of insulin from the pancreas. This combination is not indicated for the patients below 18 years of age.

Q. What are the possible side effects of Istamet 50mg/1000mg Tablet?

The use of Istamet 50mg/1000mg Tablet is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effect like lactic acidosis. On long-term use it can also lead to Vitamin B12 deficiency.

Q. Are there any specific conditions in which Istamet 50mg/1000mg Tablet should not to be taken?

The use of Istamet 50mg/1000mg Tablet should be avoided in patients with known allergy to any of the components or excipients of this medicine. The use of this medicine should be avoided in patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis or diabetic ketoacidosis.

Q. Is it safe to take alcohol while I am taking Istamet 50mg/1000mg Tablet?

No, it is not safe to alcohol along with Istamet 50mg/1000mg Tablet, as it can increase the chances of lactic acidosis.

Q. What are the instructions for storage and disposal of Istamet 50mg/1000mg Tablet?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Can the use of Istamet 50mg/1000mg Tablet lead to lactic acidosis?

Yes, the use of Istamet 50mg/1000mg Tablet can lead to lactic acidosis. It is a medical emergency which is caused by the increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is avoided in patients with underlying kidney disease, old age patients or who take large amounts of alcohol. Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Sitagliptin + Metformin and immediately consult your doctor.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Sitagliptin/metformin hydrochloride. Haarlem, The Netherlands: Merck Sharp & Dohme BV; 2018. [Accessed 08 Apr. 2019] (online) Available from:External Link
  2. Sitagliptin / metformin hydrochloride. London, UK: European Medicine Agency; 2013. [Accessed 08 Apr. 2019] (online) Available from:External Link
  3. Mayo Clinic. Sitagliptin and Metformin. [Accessed 08 Apr. 2019 ] (online) Available from:External Link
  4. Sitagliptin and metformin hydrochloride. [Accessed 08 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
Expires on or after: April, 2021

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