Irinot 40mg Injection
Product introduction
Irinot 40mg Injection is used in the treatment of cancer of colon and rectum. It shows its working by stopping or slowing down the growth of cancer cells.
Irinot 40mg Injection is given as an IV infusion into vein by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
The most common side effects of this medicine include fatigue, nausea, vomiting, weakness, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Inform your doctor if you notice fever, sore throat, and continuous episodes of diarrhea. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels.
Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.
Uses of Irinot Injection
Benefits of Irinot Injection
In Cancer of colon and rectum
Cancer of the colon and rectum, also known as colorectal cancer (CRC) or bowel cancer, is the development of cancer from two parts of the large intestine, namely, the colon or rectum. In this type of cancer, the person may notice symptoms such as blood in the stool, a change in bowel movements, weight loss, and fatigue. Irinot 40mg Injection treats and also lowers the risk of developing further cancerous growths (polyps) and bowel cancer. It kills or stops the growth of cancer cells and also prevents the multiplication of cancer cells. It is an effective, yet very toxic medicine and you should discuss the risks and benefits with your doctor. Avoid drinking alcohol or smoking while having this treatment and drink plenty of water to stay hydrated.
Side effects of Irinot Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Irinot
- Fatigue
- Nausea
- Vomiting
- Weakness
- Hair loss
- Fever
- Anemia (low number of red blood cells)
- Diarrhea
- Decreased white blood cell count (neutrophils)
- Decreased appetite
- Mucosal inflammation
How to use Irinot Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Irinot Injection works
Irinot 40mg Injection is an anti-cancer medication. It works by suppressing the activity of an enzyme (topoisomerase I) involved in DNA multiplication of the cancer cells. This slows the growth of cancer cells and eventually kills them.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Irinot 40mg Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Irinot 40mg Injection is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding
UNSAFE
Irinot 40mg Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Irinot 40mg Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
SAFE IF PRESCRIBED
Irinot 40mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Irinot 40mg Injection may not be needed in these patients. Please consult your doctor.
Use of this medicine is not recommended for patients on dialysis.
Use of this medicine is not recommended for patients on dialysis.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Irinot 40mg Injection in patients with liver disease. Please consult your doctor.
What if you forget to take Irinot Injection?
If you miss a dose of Irinot 40mg Injection, please consult your doctor.\n
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Quick tips
- Irinot 40mg Injection is used in combination with other medicines for the treatment of metastatic cancer of the colon and rectum.
- It is given via a drip into a vein (intravenous infusion).
- It may cause dizziness and visual disturbances. Do not drive or do anything that requires mental focus until you know how it affects you.
- Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine.
- Your doctor may get regular blood tests done to monitor your blood cells, kidney and liver function during treatment with this medicine.
- Inform your doctor immediately if you notice any signs of infection such as fever, sore throat or rash.
- Inform your doctor if you notice passage of blood in stools or experience dizziness or faintness, continuous episodes of nausea, vomiting, diarrhea or fever.
Fact Box
Chemical Class
Camptothecin Derivative
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Topoisomerase Inhibitors
Interaction with drugs
Taking Irinot with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytotoxic chemotherapy.
Concurrent use may cause a decrease in the ability of the bone marrow to pr
Do not consume Irinotecan from 1 day before until 1 day after taking Molgramostim. Please consult your doctor.
Concurrent use may cause a decrease in the ability of the bone marro
Do not consume Irinotecan from 14 days before until 24 days after taking Pegfilgrastim. Please consult your doctor.
Concurrent use may cause a decrease in the ability of the bone
Do not consume Irinotecan from 1 day before until 1 day after taking Sargramostim. Please consult your doctor.
Concurrent use may cause a decrease in the ability of the bone marro
Do not consume Natalizumab with Irinotecan.
Concomitant use may increase the risk of opportunistic infections.
Patient concerns
FAQs
What is Irinot 40mg Injection used for?
Irinot 40mg Injection is used to treat colon and rectal cancer, especially when the cancer has spread to other parts of the body. It is often used alone or in combination with other chemotherapy medicines.
How is Irinot 40mg Injection given?
Irinot 40mg Injection is administered as an intravenous (IV) infusion by a doctor, usually over 90 minutes. It is not taken at home, and the dose depends on your body size, health condition, and treatment plan.
Can Irinot 40mg Injection cause serious side effects?
Yes. Irinot 40mg Injection can cause serious side effects, such as severe diarrhea, dangerously low white blood cell counts, dehydration, infections, and allergic reactions. Prompt medical attention is important if you experience a high fever, chills, or persistent diarrhea.
What should I know about diarrhea caused by Irinot 40mg Injection?
Irinot 40mg Injection can cause two types of diarrhea: early-onset and late-onset. Early diarrhea may occur within 24 hours and may include sweating or stomach cramps. Late diarrhea occurs more than 24 hours after treatment and can be severe. You may be prescribed anti-diarrhea medication to manage these symptoms.
Who should not receive Irinot 40mg Injection?
Individuals should not take Irinot 40mg Injection if they are allergic to it or have had severe side effects from it previously. It may not be suitable for individuals with certain liver or bowel conditions, or those who are severely dehydrated.
Can Irinot 40mg Injection affect my ability to fight infections?
Yes. Irinot 40mg Injection can lower the number of white blood cells in your body, making it harder to fight infections. It is important to avoid close contact with people who are sick and report signs of infection, such as fever or sore throat, immediately.
What precautions should I take while on Irinot 40mg Injection treatment?
While on Irinot 40mg Injection treatment, you should stay well hydrated, follow all instructions regarding medications to manage side effects, and report any symptoms of infection, breathing problems, or unusual bleeding. Avoid grapefruit juice, as it may interfere with the medicine’s effect.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 951.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 736-37.
- Irinotecan hydrochloride trihydrate. Sandwich, Kent: Pfizer Limited; 1995 [revised May 2018]. Accessed 26 Jan. 2019] (online) Available from:
- Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Irinotecan. [Updated 2018 Dec 3]. [Accessed 18 Feb. 2020] (online) Available from:
- Central Drugs Standard Control Organisation (CDSCO). [Accessed 26 Mar. 2019] (online) Available from:
Marketer details
Name: Khandelwal Laboratories Pvt Ltd
Address: KHANDELWAL LABORATORIES PVT. LTD, 79/87 D.LADPATH, MUMBAI 400 033, INDIA
Country of origin: India
Expires on or after: October, 2026
A licensed vendor partner from your nearest location will deliver Irinot 40mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: October, 2026
A licensed vendor partner from your nearest location will deliver Irinot 40mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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MRP₹1929 7% OFF
₹1798
Inclusive of all taxes
2.0 ml in 1 vial
Cash on delivery available
Not returnable Read policy
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