Hervycta 440 + Injection

Reviewed By Dr. Mekhala Chandra, MD, MBBS

Last updated on 14 Apr 2026 | 04:21 PM (IST)

Hervycta 440 + Injection is used in the treatment of breast and stomach cancer. It works by killing the cancer cells by inhibiting HER2 (human epidermal growth factor receptor protein).

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Cold stored

Stored between 2-8°C

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Hervycta 440 + Injection

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Kintsugi 440mg Injection

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Trastuzumab (440mg)

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General Information

Contains

Trastuzumab (440mg)

Marketer

Dr Reddy's Laboratories Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

Preservative

Benzyl Alcohol

The content is shown in English

Product introduction

Hervycta 440 + Injection is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, headache, rash, insomnia, and infection. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. You must have to inform your doctor if you experience breathlessness, cough, shivering, swelling of legs and arm.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Hervycta Injection

Benefits of Hervycta Injection

Breast cancer
Breast cancer occurs when cells in the breast grow uncontrollably, often forming a lump or mass. Hervycta 440 + Injection helps to slow or stop the growth of cancer cells. It may also help shrink the tumor and prevent the cancer from coming back. It improves treatment outcomes, offers patients a better chance of recovery, reduces the risk of relapse, and brings hope for a longer and healthier life.

Stomach cancer
Stomach cancer, also known as gastric cancer, can cause symptoms like indigestion, weight loss, and stomach pain. Hervycta 440 + Injection helps to slow tumor growth and improve the effect of other cancer treatments. This targeted approach enhances treatment success, helps control the disease more effectively, and can extend survival, allowing patients to maintain a better quality of life.

Side effects of Hervycta Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Hervycta

Anemia (low number of red blood cells)
Chills
Common cold
Cough
Decreased blood cells (red cells, white cells, and platelets)
Diarrhea
Fatigue
Fever
Headache
Heart failure
Infection
Insomnia (difficulty in sleeping)
Mucosal inflammation
Nausea
Rash
Stomatitis (Inflammation of the mouth)
Taste change
Upper respiratory tract infection
Weight loss

How to use Hervycta Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Hervycta Injection works

Hervycta 440 + Injection is a recombinant IgG1 monoclonal antibody. It works against the HER2 (human epidermal growth factor receptor protein) receptors which are responsible for the over-proliferation of cancer cells in breast cancer and stomach cancer cells. It destroys the cancer cells by inhibiting HER2. It also inhibits various cancer-causing downstream signaling pathways.

All substitutes for Hervycta 440 + Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

It is given as an injection into your vein or under the skin, usually over 1 hour.
Use effective contraception method to prevent pregnancy while taking this medicine and for 7 months after you stop the treatment.
Your doctor will monitor your heart regularly while taking this medicine. Inform your doctor if you notice symptoms such as breathlessness, cough, shivering, swelling of legs and arm.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Hervycta 440 + Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Hervycta 440 + Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Hervycta 440 + Injection during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Hervycta 440 + Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Hervycta 440 + Injection in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Hervycta 440 + Injection in patients with liver disease.

Interaction with drugs

Taking Hervycta with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Do not use Trastuzumab with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).

Severe

Atazanavir (Oral Route)

Do not consume Trastuzumab with Atazanavir. If concurrent use is essential, watch out for symptoms such as taste change, nausea, diarrhea, vomiting or fatigue. Please consult your doctor. Atazanavir may raise blood levels of Trastuzumab.

Severe

Cholera Vaccine (Inactivated) (Oral Route)

Do not use Trastuzumab with Cholera Vaccine (Inactivated).

Severe

Clarithromycin (Oral Route)

Do not consume Trastuzumab with Clarithromycin. If concurrent use is essential, watch out for symptoms such as taste change, nausea, diarrhea, vomiting or fatigue. Please consult your doctor. Clarithromycin may raise blood levels of Trastuzumab.

Severe

Clarithromycin (Injection Route)

Frequently asked questions

What are the serious side effects of Hervycta 440 + Injection?

There are various side effects related to Hervycta 440 + Injection such as sore throat, fever, chills, excessive tiredness, pale skin, nosebleeds, and other unusual bruising or bleeding. One can also experience stomach pain, seizures, hallucinations, muscle cramps, and spasms. Along with that, nausea or vomiting, loss of appetite, fatigue, rapid heart beat, discoloration of urine; decreased amount of urine, difficulty in urinating, pain when urinating, and other signs of infection can also be observed with the use of Hervycta 440 + Injection. You should call your doctor immediately if you notice any such symptoms.

How long after Hervycta 440 + Injection therapy can I get pregnant?

Women of child-bearing age should use effective contraception during Hervycta 440 + Injection therapy and for 7 months after completing the treatment. You can plan your pregnancy after 7 months of treatment with Hervycta 440 + Injection.

How long should Hervycta 440 + Injection be taken?

Patients with early breast cancer should take Hervycta 440 + Injection for 1 year or until disease recurs, whichever occurs first. It is not advised to extend the treatment beyond 1 year in patients of early breast cancer.

Is fasting required before administering Hervycta 440 + Injection?

No, fasting is not required before administering Hervycta 440 + Injection. It should be given under the guidance of a doctor who is experienced in giving cancer chemotherapy and should be given only by a healthcare professional.

How is Hervycta 440 + Injection given, intravenously or intramuscularly?

There are 2 different formulations available for administration of Hervycta 440 + Injection, one is given as an infusion into a vein (intravenous infusion) and the other is given as an injection under the skin (subcutaneous injection). It is important to check the product labels to ensure that the correct formulation is being given as prescribed. Hervycta 440 + Injection intravenous formulation is not for subcutaneous use and should be given as an intravenous infusion only. Your doctor may consider switching your Hervycta 440 + Injection intravenous treatment to Hervycta 440 + Injection subcutaneous treatment (and vice versa) if considered appropriate for you.

Can Hervycta 440 + Injection be given to HER2 negative cancer patients?

No, Hervycta 440 + Injection cannot be given in patients with HER2 negative cancer cells. Hervycta 440 + Injection belongs to class of monoclonal antibody. It binds selectively to a protein called human epidermal growth factor receptor 2 (HER2). HER2 is found, in large amounts, on the surface of some cancer cells. When Hervycta 440 + Injection binds to HER2, it stops the growth and spread of the cancer cells. Therefore, it is only effective in HER2 positive patients (in which HER2 is present) and will not be beneficial for HER2 negative patients (in which HER2 is not present).

Why has my doctor advised for investigations of heart?

Hervycta 440 + Injection when used with anthracycline class of anti-cancer medicines (eg doxorubicin) may adversely affect your heart. Hence, your doctor needs to check the health of your heart initially before starting treatment and during treatment.

How frequently heart investigations are required?

Heart investigations should be performed at the starting of the treatment. It should be repeated every 3 months during treatment and every 6 months after the discontinuation of treatment until 24 months from the last administration of Hervycta 440 + Injection. Those patients who already have heart-related problems will require investigations every 12 weeks.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Anti-HER2 Monoclonal Antibody

Related lab tests

Breast Cancer (CA 15.3/ ER/ PR)

References

Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1737.
Lake DF, Briggs AD, Akporiaye ET. Immunopharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 978.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1390-91.
Trastuzumab. South San Francisco, California: Genentech, Inc.; 1998 [revised Oct. 2010]. [Accessed 27 Mar. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Trastuzumab. [Updated 2019 Jun 30]. [Accessed 19 Feb. 2020] (online) Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Dr Reddy's Laboratories Ltd
Address: Dr. Reddy's Laboratories Ltd., Village Malpur, P.O.Bhud, Baddi, Dist. Solan, H.P.

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Hervycta 440 + Injection

Save more with additional offers

Save more with additional offers

General Information

Contains

Marketer

Storage

Preservative

Product introduction

Uses of Hervycta Injection

Benefits of Hervycta Injection

Side effects of Hervycta Injection

How to use Hervycta Injection

How Hervycta Injection works

All substitutes for Hervycta 440 + Injection

Canmab 440mg Injection

Hertraz 440mg Injection

Kintsugi 440mg Injection

Hervycta 440mg Injection

Herticad 440mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Atazanavir (Oral Route)

Cholera Vaccine (Inactivated) (Oral Route)

Clarithromycin (Oral Route)

Clarithromycin (Injection Route)

Frequently asked questions

What are the serious side effects of Hervycta 440 + Injection?

How long after Hervycta 440 + Injection therapy can I get pregnant?

How long should Hervycta 440 + Injection be taken?

Is fasting required before administering Hervycta 440 + Injection?

How is Hervycta 440 + Injection given, intravenously or intramuscularly?

Can Hervycta 440 + Injection be given to HER2 negative cancer patients?

Why has my doctor advised for investigations of heart?

How frequently heart investigations are required?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Breast Cancer (CA 15.3/ ER/ PR)

References

User feedback

What are you using Hervycta Injection for?

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests