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Hepadot Injection

Protamine sulfate (NA)
Genuine
Authenticity Assured
Prescription
required
NPPA Regulated
Show Details
Hepadot Injection is a medicine which is used in the treatment of heparin overdose. It neutralizes the anti-blood clotting effect of heparin and stops excessive bleeding.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 29 Apr 2026 | 01:02 PM (IST)
₹33.5 MRP ₹36.48% off 
We do not facilitate sale of this product at present
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General Information

Contains

Protamine sulfate (NA)

Marketer

Biological E Ltd

Storage

Store below 30°C
The content is shown in English
Hepadot Injection image
Hepadot Injection image

Product introduction

Hepadot Injection is used to stop bleeding in patients caused by heparin

Uses of Hepadot Injection

  • Heparin overdose

Benefits of Hepadot Injection

Heparin overdose
Heparin overdose can lead to excessive bleeding because it thins the blood more than needed, which may occur during or after surgery or medical treatment. Hepadot Injection helps stop the bleeding by reversing the effects of heparin. It stabilizes the blood’s ability to clot properly, reducing the risk of serious bleeding complications and supporting a safe and quicker recovery.

Side effects of Hepadot Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Hepadot
  • Injection site reactions (pain, swelling, redness)

How to use Hepadot Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Hepadot Injection works

Hepadot Injection is used to counteract the anticoagulant effect of heparin and is used to stop bleeding in patients caused by heparin.

Quick tips

  • Hepadot Injection helps neutralize the effect of anti-clotting medicine heparin.
  • It should not be used to reverse the effects of other anti-clotting medicines (anticoagulants) such as warfarin.
  • It should be used under medical supervision. Do not self-administer.
  • Inform your doctor if you experience a sudden fall in blood pressure, breathlessness, or chest and abdominal pain when receiving Hepadot Injection.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Hepadot Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Hepadot Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Hepadot Injection during breastfeeding is not available. Please consult your doctor.
Driving

Driving

CAUTION
Hepadot Injection may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Hepadot Injection in patients with kidney disease. Please consult your doctor.
Liver

Liver

CAUTION
Hepadot Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

Yes. Protamine sulphate is used as an antidote in the case of overdose of lovenox.
When administered alone, protamine has an anticoagulant effect. However, when it is given in the presence of heparin, a stable salt is formed and the anticoagulant activity of both drugs is lost

Fact Box

Chemical Class

Peptides

Habit Forming

No

Therapeutic Class

OTHERS

Action Class

Heparin Antagonists

Related lab tests

Activated Partial Thromboplastin Time

Prothrombin Time

References

  1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1167-68.
  2. Protamine. Lake Zurich, Illinois: Fresenius Kabi; 2016. [Accessed 06 Apr. 2019] (online) Available from:
  3. Protamine sulfate. Wrexham: Wockhardt UK Ltd.; 1991 [revised 4 May 2018]. [Accessed 6 Apr. 2019] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Biological E Ltd
Address: Biological E. Limited, Road No. 35,Jubilee Hills, Hyderabad, Telangana -500033

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