Head-Off Tablet

Naproxen (500mg)+ Domperidone (10mg)

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Head-Off Tablet is a medicine used in the prevention of migraines. It inhibits the release of certain chemical messengers that cause pain, inflammation, and fever. It also blocks the signals in the brain that cause nausea and vomiting associated with migraines.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 11 May 2026 | 03:57 PM (IST)

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Head-Off Tablet

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Same composition

Naxpesure Forte Tablet

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Naproxen (500mg) + Domperidone (10mg)

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General Information

Contains

Naproxen (500mg)+ Domperidone (10mg)

Marketer

Hukind Lifecare Pvt Ltd

Storage

Store below 25°C

The content is shown in English

Product introduction

Head-Off Tablet may be prescribed alone or in combination with another medicine. It can be taken with or without food. The dose and duration will depend on the severity of your condition and how well it helps your symptoms. Use it regularly and do not discontinue it until the doctor tells you it is right to stop.

Using Head-Off Tablet may cause common side effects such as headaches, ringing in the ears, dizziness, tiredness, rashes, and vision changes. If you experience such side effects that do not go away or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.

In general, you should try to use the smallest amount necessary to control your symptoms. Before using the medicine, you should tell your doctor if you have any other illnesses or disorders. It may also affect, or be affected by, some other medicines you are using, so let your doctor know all the other medicines you are taking. Pregnant and breastfeeding women should consult their doctors first before using the medicine.

Uses of Head-Off Tablet

Prevention of Migraine : Head-Off Tablet helps prevent migraine, reducing symptoms like throbbing head pain, nausea, and sensitivity to light or sound.

Benefits of Head-Off Tablet

Prevention of Migraine
Migraine is a recurring condition that causes severe headaches along with nausea and vomiting. Head-Off Tablet works by blocking chemicals responsible for pain sensation and signals that trigger nausea and vomiting during migraine attacks. This helps prevent migraine attacks, reduce their frequency, and relieve associated symptoms.

Side effects of Head-Off Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Head-Off

Dryness in mouth
Ringing in ear
Altered vision
Tiredness
Dizziness
Drowsiness
Rash

How to use Head-Off Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Head-Off Tablet may be taken with or without food.

How Head-Off Tablet works

Head-Off Tablet is a combination of two medicines: naproxen and domperidone. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers that cause migraine pain. Domperidone works on the part of the brain that controls nausea and vomiting associated with migraine. Together, these medicines help relieve migraine symptoms.

All substitutes for Head-Off Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take Head-Off Tablet exactly as prescribed. Do not take more than the recommended dose.
Avoid alcohol while taking Head-Off Tablet, as it may increase dizziness and the risk of stomach bleeding.
Head-Off Tablet may cause dizziness, so avoid driving or operating machinery until you know how it affects you.
Do not take Head-Off Tablet with other NSAID painkillers unless advised by your doctor.
Inform your doctor if you have a history of stomach ulcers, acid reflux, heart disease, kidney disease, asthma, or high blood pressure.
Stop taking Head-Off Tablet and seek urgent medical help if you have black stools, vomit blood, severe stomach pain, chest pain, or swelling of the face or lips.
Seek medical advice if you experience palpitations, fainting, or severe dizziness, as domperidone may affect heart rhythm in some people.
Stay well hydrated and eat light meals if you experience nausea.
Avoid common migraine triggers such as bright light, loud noise, missed meals, alcohol, and foods that can trigger your headaches.
Consult your doctor if headaches become frequent or severe despite using Head-Off Tablet.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Head-Off Tablet

Pregnancy

CONSULT YOUR DOCTOR

Head-Off Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CAUTION

Head-Off Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

UNSAFE

Head-Off Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Head-Off Tablet may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision. This may affect your driving ability.

Kidney

CAUTION

Head-Off Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

UNSAFE

Head-Off Tablet is unsafe to use in patients with liver disease and should be avoided.
Use of Head-Off Tablet is not recommended in patients with moderate and severe liver disease.

Frequently asked questions

What is Head-Off Tablet and what is it used for?

Head-Off Tablet is used to treat migraine headaches, especially when they are associated with nausea or vomiting. It helps reduce migraine symptoms such as head pain, nausea, vomiting, and sensitivity to light or sound. The medicine works by blocking certain chemical signals in the body that cause pain and inflammation, while also helping control nausea associated with migraines. It should be taken only as prescribed by a doctor and not used regularly for other types of headaches without medical advice.

How should I take Head-Off Tablet?

Take Head-Off Tablet exactly as prescribed by your doctor. Swallow the tablet whole with water and do not crush or chew it. It may be taken with or without food, but taking it at the same time each day helps maintain consistent effects. If it causes stomach discomfort, taking it after food may help. Do not change the dose or schedule on your own. Consult your doctor if you miss doses often or if symptoms persist.

What are the side effects of Head-Off Tablet?

Common side effects of Head-Off Tablet may include headache, dizziness, tiredness, ringing in the ears, skin rash, or mild vision changes. Some people may also experience stomach discomfort or nausea. These effects are usually mild and may improve as the body adjusts to the medicine. However, consult your doctor if side effects persist, worsen, or become bothersome. Consult your doctor immediately if you have black stools, vomit blood, or severe stomach pain.

Can I drink alcohol while taking Head-Off Tablet?

It is not recommended to drink alcohol while taking Head-Off Tablet. Alcohol may increase dizziness and the risk of stomach irritation or bleeding. It may also make it harder to notice unwanted reactions from the medicine. Since the body is already dealing with migraine symptoms, alcohol may worsen discomfort or dehydration. For safety, avoid alcohol during treatment and consult your doctor if you have concerns.

Who should avoid taking Head-Off Tablet?

Head-Off Tablet should be used with caution and only under a doctor’s advice in people who are pregnant, have kidney or liver disease, heart problems, or high blood pressure. It may not be suitable during pregnancy unless clearly prescribed. Breastfeeding mothers should also consult a doctor before using it. Extra care is needed if you take other medicines or have ongoing health conditions. Always share your full medical history with your doctor before starting Head-Off Tablet.

Can Head-Off Tablet affect driving ability?

Head-Off Tablet may cause dizziness, sleepiness, tiredness, or vision problems in some people. These effects can reduce alertness and may affect your ability to drive or operate machinery safely. If you feel dizzy, unusually tired, or notice vision changes after taking the medicine, avoid driving or using heavy machines until you feel normal again. Consult your doctor if these symptoms persist.

Can I take Head-Off Tablet every day?

Head-Off Tablet should only be used in the dose and duration recommended by your doctor. It is generally taken when migraine symptoms occur or as directed for prevention, and should not be used more frequently or in higher doses than prescribed. If your headaches become frequent or severe, consult your doctor rather than increasing the dose yourself. Repeated or excessive use may worsen headaches over time. Seek urgent medical care if symptoms such as severe weakness, fainting, chest pain, breathing difficulty, seizures, confusion, black stools, or severe dehydration occur.

How many times a day can Head-Off Tablet be taken?

The number of times you should take Head-Off Tablet depends on your doctor’s instructions and your medical condition. Always follow the dosing schedule provided by your doctor and do not increase the frequency on your own. Taking more than recommended may increase the risk of side effects. If the medicine upsets your stomach, your doctor may advise taking it after food and maintaining good hydration.

Fact Box

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Hukind Lifecare Pvt Ltd
Address: Prime Enclave, Amaanat 20/21, Anantapura Gate Main Road, Yelahanka, New Town, Bangalore 560064

Vendor Details

Country of origin: India

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Why we need a prescription?

Home

Neuro Cns

Anti Migraine Preparations

Head-Off Tablet

Head-Off Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Head-Off Tablet

Benefits of Head-Off Tablet

Side effects of Head-Off Tablet

How to use Head-Off Tablet

How Head-Off Tablet works

All substitutes for Head-Off Tablet

Naprowel Forte 500mg/10mg Tablet

Napra D 500 Tablet

Minado 500 Tablet

Macprox DP 500 Tablet

Xenadom 500 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Head-Off Tablet and what is it used for?

How should I take Head-Off Tablet?

What are the side effects of Head-Off Tablet?

Can I drink alcohol while taking Head-Off Tablet?

Who should avoid taking Head-Off Tablet?

Can Head-Off Tablet affect driving ability?

Can I take Head-Off Tablet every day?

How many times a day can Head-Off Tablet be taken?

Fact Box

Habit Forming

Therapeutic Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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