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22 Jul 2020 | 06:00 PM (IST)
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Grandem MD Tablet

Prescription Required
SALT COMPOSITION
Storage
Store at room temperature (10-30°C)
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Overview

Introduction

Grandem MD Tablet is an antiemetic medicine commonly used to control nausea and vomiting due to certain medical conditions like stomach upset. It is also used to prevent nausea and vomiting caused due to any surgery, cancer drug therapy or radiotherapy.

Grandem MD Tablet will not relieve other side effects associated with cancer treatments. It also has little effect on vomiting caused by motion sickness. You should take this medicine in the dose and duration advised by your doctor. But, it is better to take this medicine at a fixed time. Remember, you should not stop taking this medicine suddenly without talking to your doctor. In case you vomit within one hour of taking a dose, then take another dose and avoid heavy meals throughout the day.

The most common side effects of taking this medicine include headache, constipation, diarrhea, and weakness. Dizziness and sleepiness may also occur, so do not drive or do anything that requires mental focus until you know how this medicine affects you. These symptoms should disappear when you stop taking the medicine but if they bother you or do not go away, your doctor may be able to suggest ways of preventing or reducing them.

Before taking this medicine, tell your doctor if you have heart or liver problems or a blockage in your stomach or intestines. Also, tell your doctor about any other medicine that you might be using, especially medicines to treat epilepsy, heart problems, cancer, and depression. These may affect, or be affected by, this medicine. If you are pregnant or breastfeeding, ask for advice from your healthcare team.

Uses of Grandem Tablet MD

Benefits of Grandem Tablet MD

In Nausea

Grandem MD Tablet blocks the action of chemicals in the body that can make you feel or be sick. It is often used to prevent nausea and vomiting that may be caused by cancer chemotherapy and radiation treatment (in adults and children). It is usually taken both before and after chemotherapy or radiation. This medicine helps you recover more comfortably from these treatments. It is also effective at preventing nausea and vomiting after an operation (in adults only). The dose will depend on what you are being treated for but always take this medicine as it is prescribed.

Side effects of Grandem Tablet MD

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Grandem

  • Sleepiness
  • Weakness
  • Headache
  • Constipation
  • Diarrhea

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Sleepiness
    If the medicine is making you drowsy during the day, stop what you are doing and sit or lie down until you feel better. You can also consider taking a nap. Physical exercises such as walking may be helpful. Do not drink alcohol, as it will make you feel more tired. Avoid driving or operating heavy equipment when you are feeling drowsy. This problem usually goes away as your body gets used to the medicine. However, if it does not, ask your doctor if you can take your medicine at bedtime or whether the dose can be reduced.
  • Coping with Weakness
    Make sure you rest and drink plenty of fluids. Eat a well-balanced diet to keep your energy levels up. Do not drink too much alcohol. Do not drive or use tools or machinery until you feel better. Other things that can help include doing some gentle exercise every day, prioritizing and pacing your activities and having a short nap if you need to. If you are still having problems after a week, speak to your doctor, as they may want to change you to a different type of medicine.
  • Coping with Headache
    Make sure you rest and drink plenty of fluids. Rest in a quiet, dimly lit room. Do not sleep more than you normally would. Do not strain your eyes (for example by looking at a screen). Do not drink alcohol. Headaches are usually temporary and usually go away with time. But, if they last longer or get worse, ask your doctor to recommend a painkiller.
  • Coping with Constipation
    Try to eat foods which are high in fiber such as fresh fruits, vegetables and cereals to increase the bulk and consistency of bowel movements. Drink plenty of water or non-alcoholic drinks and stay hydrated to promote healthy digestion. Increasing physical activities such as walking, yoga and regular exercise can also be helpful. If your condition does not improve, you can ask your doctor to prescribe you laxative medicine.
  • Coping with Diarrhea
    Keep up your intake of fluids and electrolytes (sugars and salts) to avoid getting dehydrated. Eat less fiber (avoid raw fruits, fruit juice and vegetables). Talk to your doctor about possible medication to manage diarrhea. Ask about reducing the dosage of your drug or other suitable treatments.

How to use Grandem Tablet MD

Take this medicine in the dose and duration as advised by your doctor. Do not handle the tablets with wet hands. Put it in your mouth but do not swallow it. Grandem MD Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Grandem Tablet MD works

Grandem MD Tablet is an antiemetic medication. It works by blocking the action of a chemical messenger (serotonin) in the brain that may cause nausea and vomiting during anti-cancer treatment (chemotherapy) or after surgery.

Safety Advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Grandem MD Tablet. Please consult your doctor.
Pregnancy
SAFE IF PRESCRIBED
Grandem MD Tablet is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Breastfeeding
SAFE IF PRESCRIBED
Grandem MD Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
SAFE
Grandem MD Tablet does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Grandem MD Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Grandem MD Tablet may not be needed in these patients. Please consult your doctor.
Liver
SAFE IF PRESCRIBED
Grandem MD Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Grandem MD Tablet may not be needed in these patients. Please consult your doctor.

What if you forget to take Grandem Tablet MD?

If you miss a dose of Grandem MD Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Grandem MD Tablet
₹7.38/Tablet MD
₹6/Tablet MD
save 19%
Granirex 1mg Tablet MD
Bennet Pharmaceuticals Limited
₹7.15/Tablet MD
save 3%

Quick Tips

  • You have been prescribed Grandem MD Tablet for prevention of nausea and vomiting caused after surgery or due to chemotherapy and radiotherapy.
  • Unlike some other nausea medicines, the side effects for Grandem MD Tablet are relatively mild.
  • It is fast-acting and starts working within 30 minutes.
  • If you vomit within one hour of taking a dose, take another dose.
  • Avoid heavy meals and try eating small nourishing snacks throughout the day. Also, sip water regularly to help avoid dehydration.

Fact Box

Chemical Class
Indazole Derivative
Habit Forming
No

Interaction with Drugs

Taking Grandem with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Brand(s): Acicod, Montokuf, Codine Sulphate
SERIOUS
Brand(s): Parvodex
SERIOUS
Brand(s): Nalfy, Nacphin, Ruffy
SERIOUS
Brand(s): Wintal
SERIOUS

Patient Concerns

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My wife is 13 week pregnent her docter change her tablet from mvista to doxynate plus me I know the reason is both tablet aee same. Docter asked to taje doxynate plus 2 tablet at bed time.please suggest.
Dr. Megha Tuli
Obstetrics and Gynaecology
Doxynate is tablet to stop vomiting dear. It is ok to take them at bed time. It is widely recommended to take for nausea and vomiting of pregnancy.
Dear Sir/madam Pls advise whats the utility difference in : (1) Ondem-8mg & Ondem-8mg-MD (2) Evion-400 & Evion-600
Dr. Pushkar Mani
Physician
Ondem 8 mg/MD (sustained release) are the same, prescribed in different doses at different intervals, depending on the cause of nausea and vomiting.Evion is basically Vitamin E. 400 and 600 mg are two different doses, thats all.
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Do you have any questions related to Grandem MD Tablet ?

User Feedback


FAQs

Q. What is Grandem used for?

Grandem is an antiemetic medicine used to treat and prevent nausea or vomiting caused after any surgical procedure or due to certain medicines, stomach upset, or cancer treatment. It also prevents nausea due to motion sickness to some extent.

Q. What are the side effects of Grandem?

The most common side effects of Grandem are sleepiness, weakness, headache, constipation and diarrhea. However, these are not usually bothersome and resolve in some time on their own. Consult your doctor, if the symptoms worry you or persist for a longer duration. Your doctor will suggest ways to cope up with these side effects and to prevent them in future.

Q. Is Grandem safe to be used in pregnant women?

Grandem did not show any adverse effects in research studies done on animals. However, since the safety and efficiency of Grandem in pregnant women is unknown. It is not recommended to be used in women who are pregnant women or if you are planning to conceive unless prescribed by your doctor.

Q. Is Grandem better than Ondansetron?

Grandem and Ondansetron belong to the same class of medicines, that is serotonin 5-HT3 receptor antagonists. Both these medicines help prevent nausea and vomiting effectively. However, some studies suggest that Grandem is more effective than Ondansetron. According to some reports, Grandem is comparatively well tolerated, quicker in action and alleviates nausea and vomiting relatively faster.

Q. Does Grandem cause constipation?

Yes, Grandem may cause constipation as one of the common side effects. However, this is usually not bothersome. Taking a fiber-rich diet can enhance your digestion and avoid constipation. You may also consider taking laxatives for relief and drink plenty of water too. Avoid drinking alcohol as it may worsen your constipation. If you still face issues, please consult your doctor to know about ways to treat it.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Granisetron. Hertfordshire: Generics [UK] Limited; 2005 [revised Nov. 2018]. [Accessed on 28 Mar. 2018] (online) Available from:External Link
  2. Drugs.com. Granisetron Pregnancy and Breastfeeding Warnings. [Accessed 28 Mar. 2019] (online) Available from:External Link
  3. Central Drugs Standard Control Organisation (CDSCO). [Accessed 28 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Mercantile Chamber, 3rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai – 400 001, India.
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