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food interaction for GRAMONEX

alcohol interaction for GRAMONEX

pregnancy interaction for GRAMONEX

lactation interaction for GRAMONEX

Avoid Gramonex injection with grapefruit juice.
Gramonex injection may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
Gramonex injection may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Nalidixic Acid(1.5 gm)


Nalidixic Acid is used in the treatment of bacterial infections

How it works

Nalidixic Acid is an antibiotic. It kills bacteria by inhibiting the DNA replication.

Common side effects

Nausea, Pain, Rash, Changes in color vision, Convulsion, Decreased pain sensitivity, Diarrhoea, Dizziness, Drowsiness, Headache, Increased body temperature, Skin redness, Stomach discomfort, Stomach pain, Inflammation of tendons, Vertigo, Vomiting, Weakness


Metronidazole is used in the treatment of diarrhoea and bacterial infections

How it works

Metronidazole is an antibiotic. It kills the bacteria that cause infections.

Common side effects

Allergic reaction, Itching, Skin rash, Joint pain, Bitter taste, Dark colored urine, Dry mouth, Furry tongue, Loss of appetite, Mouth irritation, Throat irritation, Nasal congestion, Stomach upset, Numbness, Tingling sensation, Weakness, Fever, Vomiting, Diarrhoea


No substitutes found

Expert advice FOR GRAMONEX

  • Do not take medicines that contain magnesium, aluminium, calcium, sucralfate, iron, or zinc preparations within 2 to 3 hours of taking nalidixic acid.
  • Do not drink products that contain caffeine while taking nalidixic acid.
  • Continue taking nalidixic acid even if you feel better. Do not stop taking this medication as it may result in relapse of the infection. 
  • Do not drive or operate machinery as nalidixic acid can cause drowsiness, dizziness, or blurred vision. 
  • Do not consume alcohol as nalidixic acid as it may worsen the side effects.
  • Avoid exposure to sun while taking nalidixic acid. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Seek immediate medical attention if you develop stomach pain or cramps, severe diarrhea, or bloody stools.
  • Consult your doctor if you develop signs of infections as long-term or repeated use of nalidixic acid may cause secondary infections. 
  • Inform your doctor if you are on nalidixic acid treatment as it may affect some tests for urine glucose in patients with diabetes.
  • Use of nalidixic acid is not recommended in children younger than 3 months old or younger than 9 years old with diarrhea or a gastrointestinal infection.
  • You may be monitored with blood tests, kidney and liver function test, if you are on long-term treatment with nalidixic acid.

Frequently asked questions FOR GRAMONEX

Nalidixic Acid

Q. Is nalidixic acid an antibiotic / quinolone / broad spectrum / fluoroquinolone?
Yes, Nalidixic acid is a broad spectrum quinolone antibiotic

Q. How does nalidixic acid work/ inhibit bacterial growth /inhibit DNA synthesis?
It works by killing the bacteria that are causing an infection. It does this by entering the bacterial cells and inhibiting a bacterial enzyme called DNA-gyrase

Q. What does nalidixic acid target?
It stops the production of essential proteins needed by bacteria

Q. How does nalidixic acid inhibit DNA synthesis?
Nalidixic acid acts by inhibiting DNA synthesis, probably by interfering with DNA polymerisation.


Q. Is metronidazole safe?
Yes, metronidazole is a relatively safe drug if used in prescribed dose and for prescribed duration as advised by your doctor

Q. What is metronidazole?
Metronidazole is an antibiotic

Q. Is it antibiotic or pain killer?
Metronidazole is an antibiotic and not pain killer

Q. What it is used for?
It is used for infections of the dental cavity, ears, sinus, throat, lungs, stomach, intestine, brain and bones

Q. Is metronidazole same as Flagyl?
Yes. Flagyl is a branded medicine containing metronidazole

Q. Does metronidazole cure STDs or yeast infections?
Metronidazole cures genital infections like bacterial vaginosis and gonorrhea. It does not cure chlamydia or vaginal yeast infections

Q. Does metronidazole affect birth control?
There is no evidence of metronidazole affecting contraception. Please consult your doctor to confirm whether you require a secondary birth control measure while taking metronidazole

Q. Is metronidazole an OTC product?
No, metronidazole is not an OTC product

Q. Can metronidazole cause nausea, vomiting, constipation or irregular monthly periods?
Metronidazole may cause nausea, vomiting, constipation or upset stomach. However, there is no evidence of metronidazole affecting monthly periods. If you notice any such symptoms, please consult your doctor.


Content on this page was last updated on 12 January, 2017, by Dr. Varun Gupta (MD Pharmacology)