1mg, best e pharmacy in India


MRP: Rs. 175 for 1 strip(s) (21 tablets each)
Unfortunately, we don't have any more items in stock
Report Error

Composition for FREWIL

Cyproterone(2 mg),Estradiol(0.035 mg)

food interaction for FREWIL

alcohol interaction for FREWIL

pregnancy interaction for FREWIL

lactation interaction for FREWIL

There is no data available. Please consult doctor before consuming the drug.
Interaction with alcohol is unknown. Please consult your doctor.
Frewil 2 mg/0.035 mg tablet is highly unsafe in women who are or may become pregnant.
Human and animal studies have shown significant adverse effects on the fetus and should not be given under any circumstances. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Cyproterone(2 mg)


Cyproterone belongs to a group of medicines known as anti-androgens. It is used in the treatment  of prostate cancer, and to control the sex drive in men with hypersexuality (an increased sex drive).

How it works

Cyproterone belongs to a class of medications called anti-androgens. It acts by blocking as well as reducing the effects of male sex hormone testosterone in the body.

Common side effects

Abnormal milky discharge from breast, Altered libido, Bleeding, Blisters on skin, Burning sensation, Decreased sexual function, Decreased libido, Discoloration of skin, Increased hair growth, Impotence, Swelling of breast, Breast discomfort, Weight loss, Liver enzyme increased
Estradiol(0.035 mg)


Estradiol is used as a hormone replacement therapy (HRT) in post-menopausal women or women with absent ovaries or ovaries unable to produce enough estrogen and  to prevent fragility of bones (osteoporosis). Estradiol is sometimes also used as part of breast cancer treatment in women and men, and prostate cancer in men. It is used at a very low dose in combination with a progestogen hormone as oral contraceptive.

How it works

Estradiol is a form of estrogen, a female sex hormone produced by the ovaries. It acts by replacing the natural hormone in the body, when the latter is deficient.

Common side effects

Vomiting, Nausea, Abdominal bloating, Acne, Altered menstrual cycle, Absence of menstrual periods, Ankle swelling, Limb swelling, Breast tenderness, Breast enlargement, Change in appetite, Dark skin patches, Difficulty in wearing contact lense, Hair loss, Stomach cramp, Vaginal discharge, Vaginal itching, Weight loss, Weight gain


No substitutes found

Expert advice for FREWIL

  • Do not start or continue cyproterone, if you are allergic to cyproterone or any of its ingredients.
  • Do not take cyproterone, if you are suffering from diabetes mellitus; severely depressed; sickle cell anemia (a disease characterized by abnormal shape of red blood cells); shortness of breath; or from any cancer other than prostate cancer.
  • Regular check-up for blood counts and function of adrenal glands and liver will be required. Your doctor will advise you regarding the same.
  • Patients with rare hereditary problems of intolerance to some sugars (galactose intolerance, Lapp lactase deficiency or glucose galactose malabsorption) should not take this medicine.
  • Avoid drinking alcohol while taking cyproterone.
  • Cyproterone may cause fatigue or weakness and, therefore, caution has to be taken before operating an automobile or machinery or engaging in activities requiring mental alertness and coordination.

Frequently asked questions for FREWIL


Q. Is cyproterone a steroid/progesterone?
Cyproterone is an anti-androgen that decreases the effect of male sex hormone testosterone in the body. It is related in structure to progesterone.
Q. Is cyproterone safe?
Cyproterone is safe, if used at prescribed doses for the prescribed duration as advised by your doctor.
Q. What are the uses of cyproterone?
Cyproterone belongs to a class of medications called anti-androgens. It acts by blocking as well as reducing the effects of male sex hormone testosterone in the body.

Q. How does it work?
 It is used to suppress the effects of LHRH (luteinizing hormone releasing hormone; hormone which causes release of testosterone in men). It is used to reduce the excessive rise of testosterone (flare) when LHRH-like drugs are used (e.g. after prostate removal in prostate cancer).
Q. Does cyproterone lower testosterone?
Yes, cyproterone lowers testosterone by inhibiting the release of luteinizing hormone releasing hormone (LHRH) that is responsible for testosterone release in men.
Q. Does Yasmin (drosperinone/ ethinyl estradiol contains cyproterone?
No, it does not contain cyproterone.


Q. Is estradiol and estrogen the same/ is estradiol the same as progesterone/ is estradiol a synthetic hormone/does estradiol valerate work/ what is evalon cream?
Estradiol is the most potent natural estrogen (or “estrogen”) produced by ovaries in female. It is different from another female hormone that is progesterone. It is not a conjugated estrogen and it not a synthetic hormone. Estradiol valerate and Evalon vaginal cream works same as estradiol.
Q. Can I take estrogen for polycystic ovary syndrome (PCOS)?
Polycystic ovary syndrome (PCOS) is mainly a result of hormonal disturbance in which there are high levels of male hormones in the body. Oral contraceptive pills containing low dose estrogen and progestogen are commonly prescribed to reduce the levels of endogenous hormone, which helps regularize the menstrual cycle, reduce male hormone levels and decrease acne associated with PCOS. Always consult your doctor before using any medication.
Q. What can I take for estrogen dominance?
A balanced diet, exercise, a healthy life style and less exposure to environmental pollutants is what works best to restore the normal hormone balance and reduce estrogen dominance. Your doctor may also start a progesterone therapy, compounds that promote bile secretion, lipotropic formulas (excrete extra estrogen from body), substance which deactivate toxic substances and excess hormones to remove extra estrogen from your body.
Q. What can I take for estrogen deficiency?
For estrogen deficiency, treatment is based on the underlying cause. Your doctor may choose from a variety of medications depending upon your condition for e.g. young or old with menopause, estrogen deficiency or high progesterone levels, etc. You may be given bio-identical estradiol or estriol or counterbalance with natural progesterone in the form of micronized capsules, etc.
Q. Can I take estrogen forever?
The length of necessity of hormone therapy varies from person to person and the condition for which it is being treated for.
Q. Is estradiol safe/ stop your period/ increase libido/cause constipation/ cause high blood pressure/ make you sleepy/ cause blood clots/ cause insomnia/ cause bloating/ make you emotional?
Estradiol is safe if used at recommended dosage and duration. Estradiol can stop your periods. It may cause high blood pressure and blood clots on long-term use. Other side effects are not confirmed but may occur with some patients. Consult your doctor if you experience one of them.
Q. Is estradiol gluten free?
Estradiol preparations are gluten free. However, as the content of excipients differs according to the manufacturer, please refer to the package insert of the particular preparation/brand that you have been prescribed.
Q. Is estradiol a conjugated estrogen/ better than Premarin?
Estradiol is a synthetic hormone, whereas Premarin contains conjugated estrogen. Both are different types of estrogen and have comparable benefit and side-effect profile.


Content on this page was last updated on 29 March, 2014, by Dr. Varun Gupta (MD Pharmacology)