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Folisurge 450 Injection is used in the treatment of infertility in women. It is also helpful in the treatment of male hypogonadism (delayed puberty, and low sperm count). It works by releasing the eggs from the ovary in women and by increasing the testosterone level in men.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 16 Apr 2026 | 12:45 AM (IST)
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1 ml Injection
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Folisurge 450 Injection image
Folisurge 450 Injection image

Product introduction

Folisurge 450 Injection is given as an injection under the supervision of a doctor. Your doctor will decide the right time to take the injection, so always follow your doctor's advice. The dose and how often you take it depends on what you are taking it for. You should take this medicine for as long as it is prescribed for you.

The most common side effects of this medicine include injection site allergic reactions, swelling of the breast in males, and acne. If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them.

Before taking this medicine, tell your doctor if you have ever had heart disease, or had an ovarian cyst, or had thyroid gland disorder. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Tell your doctor if you are pregnant or breastfeeding. You should avoid alcohol or have to follow doctor advice related to diet while taking this medicine.

Uses of Folisurge Injection

Benefits of Folisurge Injection

Female infertility
Folisurge 450 Injection helps in normal development of an egg in a woman's ovary (female reproductive organ), and stimulates the release of a healthy, matured egg. This helps to treat infertility in women and increases the chance of a successful pregnancy. It is given as an injection by a doctor or nurse and should not be self-administered. You should use the medicine as prescribed for it to be effective.
Male hypogonadism
Male Hypogonadism is the improper functioning of reproductive organs, that is, testes in males, which causes failure to produce sex hormones required for fertility. Folisurge 450 Injection acts as the male sex hormone, testosterone and therefore, improves sperm production in males. This can reduce infertility and helps to treat hypogonadism in males. Follow your doctor’s instructions carefully to get the most benefit.

Side effects of Folisurge Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Folisurge
  • Injection site allergic reaction
  • Acne
  • Swelling of breast in male
  • Varicose veins

How to use Folisurge Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Folisurge Injection works

Folisurge 450 Injection is a hormone. In females, it works by stimulating the release of estrogen which helps in the growth and development of the egg before release. In males, it helps in the production of sperms.

All substitutes for Folisurge 450 Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • It may also be used to stimulate sperm formation in men.
  • The injection is administered under the skin. Follow the recommended dosage and monitoring schedules to minimise the possibility of ovarian hyperstimulation.
  • Inform your doctor immediately if you have severe pelvic pain, nausea, vomiting, diarrhea, sudden weight gain, trouble breathing, or decreased or no urination during treatment, as these could be symptoms of ovarian hyperstimulation syndrome (OHSS).
  • Do not use Folisurge 450 Injection if you are already pregnant or breastfeeding.
  • Folisurge 450 Injection stimulates the production of eggs in women undergoing treatment for infertility.
  • Your doctor may prescribe more than one medicine as part of your suggested pregnancy plan.
  • Pregnancy following treatment with Folisurge 450 Injection is more likely to result in a multiple pregnancy (twins or more).

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Folisurge 450 Injection. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Folisurge 450 Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Folisurge 450 Injection during breastfeeding is not available. Please consult your doctor.
Driving

Driving

SAFE
Folisurge 450 Injection does not usually affect your ability to drive.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Folisurge 450 Injection in patients with kidney disease. Please consult your doctor.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Folisurge 450 Injection in patients with liver disease.

Frequently asked questions

Folisurge 450 Injection contains Follitropin alfa which is a type of Follicle Stimulating Hormone produced naturally by the body. It is used in women who are unable to ovulate. It works by stimulating the growth of follicles (which contain eggs) in the ovary. This helps in the release of a properly developed egg at the time of ovulation. It is also used in assisted reproductive technology (ART) procedures such as in-vitro fertilization (IVF), which help women to become pregnant. It may also be used in adult men who are infertile due to lack of certain hormones and inability to produce enough sperm cells.
Folisurge 450 Injection is an injection given subcutaneously (just under the skin). The dose and treatment duration depend on the ovarian response of the patient.
Ideally, you should try not to miss a dose of Folisurge 450 Injection. However, please talk to your doctor as soon as you remember that you have missed a dose.
The most common side effect is a local site reaction at the injection site (pain, redness, swelling, and irritation). The other common side effects are a headache, ovarian cysts, abdominal pain or cramping, nausea, vomiting, diarrhea and bloating. If any of these side effects bother you, please consult with your doctor. In addition, this medicine may increase the likelihood of conditions like ovarian hyperstimulation syndrome (OHSS), multiple pregnancy or miscarriage.

Fact Box

Chemical Class

Peptides

Habit Forming

No

Therapeutic Class

GYNAECOLOGICAL

Action Class

Gonadotropins

References

  1. Parker KL, Schimmer BP. Introduction To Endocrinology: The Hypothalamic-Pituitary Axis. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1117-120.
  2. Masters SB. Hypothalamic & Pituitary Hormones. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 650-53.
  3. OLLISTIM AQ Cartridge (follitropin beta injection). Ravensburg, Germany: Vetter Pharma-Fertigung GmbH & Co. KG; 1997 [revised Jun. 2010]. [Accessed 28 Jan. 2019] (online) Available from:
  4. Follitropin alfa. Rockland, Massachusetts: SERONO, INC. [Accessed 03 Apr. 2019] (online) Available from:
  5. Recombinant Human Follicle Stimulating Hormone. Intas; 2024. [Accessed 16 Apr. 2026] (online). Available from:
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User feedback

Female infertility
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Male hypogonadism
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Intas Pharmaceuticals Ltd
Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Folisurge 450 Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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