Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Exact 4 Tablet is to be taken empty stomach. Avoid Exact 4 Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
Exact 4 Tablet is a combination of four medicines: Isoniazid, rifampicin, ethambutol and pyrazinamide which treat tuberculosis. Isoniazid works by preventing the TB bacteria from forming their own protective covering, while rifampicin inactivates a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Ethambutol and pyrazinamide, on the other hand work by slowing the growth of these bacteria.
Exact 4 Tablet may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
WEIGH RISKS VS BENEFITS
Exact 4 Tablet may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Exact 4 Tablet is probably safe to use during lactation.
Limited human data suggests that the drug does not represent a significant risk to the baby.
Do not drive unless you are feeling well. Exact 4 Tablet occasionally causes sight problems and tingling or numbness in hand or feet. After taking this medicine you should not drive until you know how it affects you.
Exact 4 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Exact 4 Tablet may be needed. Please consult your doctor. Kidney function tests are advisable before the start of this medicine.
Exact 4 Tablet should be used with caution in patients with liver disease. Dose adjustment of Exact 4 Tablet may be needed. Please consult your doctor. Regular monitoring of liver function tests is advised before and after the start of the treatment.