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PhD (Pharmacology), PGDPRA
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Last updated on:
16 Jul 2019 | 04:45 PM (IST)
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Exact 2 Tablet


Overview

Uses of Exact 2 Tablet

Exact 2 Tablet side effects

Common
  • Dark colored urine
  • Rash
  • Vomiting
  • Jaundice
  • Fever
  • Increased liver enzymes
  • Nausea
  • Peripheral neuropathy (tingling and numbness of feet and hand)

How to use Exact 2 Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Exact 2 Tablet is to be taken empty stomach.
Avoid Exact 2 Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How Exact 2 Tablet works

Exact 2 Tablet is a combination of two antibiotics: Rifampicin and Isoniazid, which treats tuberculosis (TB). Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Isoniazid prevents these bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.

Exact 2 Tablet related warnings

Alcohol
CAUTION
Exact 2 Tablet may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
Pregnancy
WEIGH RISKS VS BENEFITS
Exact 2 Tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Lactation
SAFE
Exact 2 Tablet is safe to use during lactation. Human studies have shown that either the drug does not pass into the breastmilk in significant amount or is not expected to cause toxicity to the baby.
Driving
Do not drive unless you are feeling well.
Exact 2 Tablet can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.
Kidney
CAUTION
Exact 2 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Exact 2 Tablet may be needed. Please consult your doctor.
Liver
CAUTION
Exact 2 Tablet should be used with caution in patients with liver disease. Dose adjustment of Exact 2 Tablet may be needed. Please consult your doctor.
Use of Exact 2 Tablet is not recommended in patients with severe liver disease.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Exact 2 Tablet
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Expert Advice

  • You have been prescribed Exact 2 Tablet for the treatment of tuberculosis.
  • Finish the full course of the medication, even if you feel better. Stopping it early may make the infection come back.
  • Take it on an empty stomach, preferably at the same time everyday.
  • It may discolour your urine, sweat, saliva and tears a reddish-orange colour. This is normal and not harmful.
  • Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
  • Avoid drinking alcohol while taking Exact 2 Tablet as this may increase the risk of side effects on the liver.
  • Use an alternative or additional contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Exact 2 Tablet as it may make hormonal contraceptives such as the pill less effective.
  • Do not take indigestion remedies (antacids)  within at least two hours of taking Exact 2 Tablet.

Patient Concerns

Questions Related to Exact 2

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My mother have a history of gas problem and after that we consult doctor and they course her a intestines tuberculosis medicine akt-fd for 18 month, after it they told us to course completed and told fine no problem, other doctors too cant find any problem and tell to take gastric medicine only - - but she have problem in right hand side abdominal. Is this gastric problem or something else that doctors can't find exact. Pls help us
Dr. Ila Jain Khandelwal
Pathologist
Hi Its very difficult for me to suggest you anything without examining you. It can be due to gastric problem. I suggest you should yourself to a general practitioner
After having tuberculosis diagnosed she has been recommended to have R cinex EZ 2 tablets daily for 2 months then after 1tablet Risorine for 1 month and now doctor has recommended onceagain to have R cinex EZ 2tables on alternate days what to do.
Dr. Anshum Aneja Arora
Lungs Specialist
TB treatment is in 2 phases1. Intensive phase where tabs RHZE are given as in your case and in the second phase called continuation phase one one the medicines is stopped nad others continued.Please discuss with your doctor or see another doctor nearby for opinion since , the treatment may have to be modified, read about TB at http://www.arohealth.com/pulmonary-tuberculosis/
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FAQs

Q. What are the instructions for storage and disposal of Exact 2?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. What is Exact 2?

Exact 2 is a combination of two medicines: Rifampicin and Isoniazid. It is used in the treatment of tuberculosis. Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by tuberculosis bacteria to make essential proteins and reproduce. Isoniazid prevents the tuberculosis causing bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.

Q. What is the most important information I should know about the Exact 2?

Take the proper course of drug that has been prescribed to you. Do not stop in between even if you begin to feel better. Avoid alcohol while taking this medicine as it increases the risk of damage to your liver during treatment. Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.

Q. What is the best time to take Exact 2?

Take Exact 2 exactly as directed by your doctor. It is best to take the medicine on an empty stomach one hour before or two hours after meals.

Q. Does Exact 2 cause change in urine color/turn urine orange?

Yes, Exact 2 can change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful.

Q. Does the use of Exact 2 make birth control pills ineffective?

Yes, Exact 2 can make birth control pills less effective. So, ask the doctor about using a birth control method which does not affect your hormone levels (such as a condom, diaphragm and spermicide).

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Isoniazid/rifampicin. Guildford Surrey: Aventis Pharma Limited; 1999 [revised 12 Mar. 2019]. [Accessed on 10 Apr. 2019] (online) Available from:External Link
  2. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Hilal-Dandan R, Brunton LL. Goodman and Gilman's Manual of Pharmacology and Therapeutics. 2nd ed. New York, New York: The McGraw-Hill Companies, Inc.; 2014. [Accessed 10 Apr. 2019] (online) Available from:External Link
  3. Isoniazid. Nottingham, Nottinghamshire: Boots Contract Manufacturing; 2015. [Accessed 10 Apr. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
Marc Laboratories Limited, Plot No. 112, HP HIDC, Baddi, Solan-173205, Himachal Pradesh, India
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