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Last updated
04 Feb 2022 | 07:02 PM (IST)

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Estramin 140mg Capsule

Prescription Required
SALT COMPOSITION
Storage
Store in a refrigerator (2 - 8°C). Do not freeze.

Product introduction

Estramin 140mg Capsule is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy.

Estramin 140mg Capsule should be taken on an empty stomach. The calcium in the stomach might affect the working of drug, so better to avoid milk, dairy products such as cheese and avoid taking it in combination with an antacid or other medicine containing calcium, magnesium or aluminum. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, vomiting, anemia (low number of red blood cells), increased liver enzymes and fluid retention.  If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Regular blood tests are required to check your blood, liver function and the level of calcium in your blood.

Before taking it, tell your doctor if have heart problem, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Estramin Capsule

Benefits of Estramin Capsule

In Prostate cancer

Prostate gland is a small walnut-sized gland that produces a fluid called seminal fluid that nourishes and transports sperms in males. The most common symptom of prostate cancer is difficulty with urination, but sometimes there are no symptoms at all. Estramin 140mg Capsule decreases or stops the growth of cancer cells by decreasing the amount of testosterone (natural hormone in males) in men. This also relieves difficulty in passing urine and makes it easier for you to urinate.

Side effects of Estramin Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Estramin

  • Nausea
  • Vomiting
  • Anemia (low number of red blood cells)
  • Increased liver enzymes
  • Decreased white blood cell count
  • Diarrhea
  • Breast enlargement in male

How to use Estramin Capsule

Take this medicine in the dose and duration as advised by your doctor. Estramin 140mg Capsule may be taken with or without food, but it is better to take it at a fixed time.
Avoid Estramin 140mg Capsule with dairy products such as milk, cheese, curd, butter, paneer and ice cream.

How Estramin Capsule works

Estramustine belongs to a class of anticancer/cytotoxic drugs called antimicrotubule agents.  It works by interfering with production of certain proteins which are necessary for tumor cell growth and reproduction. It also increases the estrogen levels, which in turn interferes with prostate cancer by slowing/stopping the growth of cancer cells.
.

Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Estramin 140mg Capsule. Please consult your doctor.
Pregnancy
UNSAFE
Estramin 140mg Capsule is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Estramin 140mg Capsule during breastfeeding is not available. Please consult your doctor.
Driving
CONSULT YOUR DOCTOR
It is not known whether Estramin 140mg Capsule alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
SAFE IF PRESCRIBED
Estramin 140mg Capsule is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Estramin 140mg Capsule may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Estramin 140mg Capsule should be used with caution in patients with liver disease. Dose adjustment of Estramin 140mg Capsule may be needed. Please consult your doctor.
Use of Estramin 140mg Capsule is not recommended in patients with the severe liver disease.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Estramin 140mg Capsule
₹129.2/Capsule
X TRANT 140 MG CAPSULE
Natco Pharma Ltd
₹146.5/capsule
13% costlier
Estram 140mg Capsule
United Biotech Pvt Ltd
₹159.5/capsule
23% costlier

Quick tips

  • Estramin 140mg Capsule should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
  • Avoid taking antacids, calcium or magnesium, milk products and multivitamins, as these may interfere with the effect of the medicine.
  • Your doctor may get regular blood tests done to monitor your calcium level, liver function, blood cell count in your blood.
  • Use an effective method of birth control to avoid pregnancy while taking this medication.
  • Do not stop taking medicine without talking to your doctor first.

Fact Box

Chemical Class
Estradiol, and Nitrogen Mustard Compounds
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Anticancer-others

Patient concerns

arrow
I have problem of frequent urination at night. My father had same at his time.Doctor told me that I am having BPH.Also I went through PSA whose result is 1.8 increased prostate gland size is 40 which came in ultrasound report .When doctor did some test by inserting his finger in my rectal area I felt abnormal pain.doctor asked me to go for a culture test so as to check which can be the best medicine for BPH for me. Kindly suggest if it can be something else like prostate cancer.
Dr. Vijay Sharnangat
Medical Oncology and Hematology
May not be prostate cancer, it is only begnin enlargement of prostate.
Do i have prostrate cancer. Married but now having difficulty in having relation with wife. Penis not hard in the morning. Having problem with self spontaneous erection. Please help. God Bless.
Dr. Sanjay Singh Rai
Medical Oncology and Hematology
Not a symptom of prostate cancer
arrow

FAQs

Q. What is Estramin 140mg Capsule phosphate?

Estramin 140mg Capsule belongs to a class of anticancer/cytotoxic drugs called antimicrotubule agents used in the treatment of prostate cancer.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1709.
  2. Estramustine sodium phosphate. Sandwich, Kent: Pfizer Limited; 2002 [revised Feb. 2019]. [Accessed 20 Feb. 2019] (online) Available from:External Link
  3. Drugs.com. Estramustine Pregnancy and Breastfeeding Warnings. [Accessed 27 Mar 2019] (online) Available from:External Link
  4. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:External Link

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Country of origin: India
MRP
1292
Inclusive of all taxes
10 capsules in 1 strip
SOLD OUT
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