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Xtrant 140mg Capsule

Estramustine (140mg)
Genuine
Authenticity Assured
Prescription
required
Cold stored
Stored between 2-8°C
Xtrant 140mg Capsule is used in the treatment of cancer of the prostate gland. It may be also used to treat other conditions, as determined by the doctor. It is sometimes used with certain other medicines as part of combination chemotherapy.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 24 Dec 2025 | 01:00 AM (IST)
₹6580
₹7287.19
10% off
100 capsules
Get by Thursday, 25 June
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Gurgaon
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Online only

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 Expiry after

Expiry after

Sep, 2026

 
 
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General Information

Contains

Estramustine (140mg)

Marketer

Natco Pharma Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Xtrant 140mg Capsule image
Xtrant 140mg Capsule image

Product introduction

Xtrant 140mg Capsule should be taken on an empty stomach. The calcium in the stomach might affect the working of drug, so better to avoid milk, dairy products such as cheese and avoid taking it in combination with an antacid or other medicine containing calcium, magnesium or aluminum. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

The most common side effects of this medicine include nausea, vomiting, anemia (low number of red blood cells), increased liver enzymes and fluid retention.  If these bother you or appear serious, let your doctor know. There may be ways of reducing or preventing them. Regular blood tests are required to check your blood, liver function and the level of calcium in your blood.

Before taking it, tell your doctor if have heart problem, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy.

Uses of Xtrant Capsule

Benefits of Xtrant Capsule

Prostate cancer
Prostate gland is a small walnut-sized gland that produces a fluid called seminal fluid that nourishes and transports sperms in males. The most common symptom of prostate cancer is difficulty with urination, but sometimes there are no symptoms at all. Xtrant 140mg Capsule decreases or stops the growth of cancer cells by decreasing the amount of testosterone (natural hormone in males) in men. This also relieves difficulty in passing urine and makes it easier for you to urinate.

Side effects of Xtrant Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Xtrant
  • Nausea
  • Vomiting
  • Anemia (low number of red blood cells)
  • Increased liver enzymes
  • Decreased white blood cell count
  • Diarrhea
  • Breast enlargement in male

How to use Xtrant Capsule

Take this medicine in the dose and duration as advised by your doctor. Xtrant 140mg Capsule may be taken with or without food.
Avoid Xtrant 140mg Capsule with dairy products such as milk, cheese, curd, butter, paneer and ice cream.

How Xtrant Capsule works

Estramustine belongs to a class of anticancer/cytotoxic drugs called antimicrotubule agents.  It works by interfering with production of certain proteins which are necessary for tumor cell growth and reproduction. It also increases the estrogen levels, which in turn interferes with prostate cancer by slowing/stopping the growth of cancer cells.
.

All substitutes for Xtrant 140mg Capsule

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Xtrant 140mg Capsule should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
  • Avoid taking antacids, calcium or magnesium, milk products and multivitamins, as these may interfere with the effect of the medicine.
  • Your doctor may get regular blood tests done to monitor your calcium level, liver function, blood cell count in your blood.
  • Use an effective method of birth control to avoid pregnancy while taking this medication.
  • Do not stop taking medicine without talking to your doctor first.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Xtrant 140mg Capsule. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Xtrant 140mg Capsule is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Xtrant 140mg Capsule during breastfeeding is not available. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Xtrant 140mg Capsule alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

SAFE IF PRESCRIBED
Xtrant 140mg Capsule is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.
Liver

Liver

CAUTION
Xtrant 140mg Capsule should be used with caution in patients with liver disease. Dose adjustment may be needed.
Use of Xtrant 140mg Capsule is not recommended in patients with the severe liver disease.

Interaction with drugs

Taking Xtrant with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Cholera Vaccine (Inactivated) (Oral Route)

Concurrent use must be avoided. Please consult with your doctor regarding appropriate interval between Estramustine and Cholera Vaccine (Inactivated).
Life-threatening

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Concurrent use must be avoided. Please consult with your doctor regarding appropriate interval between Estramustine and Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted).
Life-threatening

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Concurrent use must be avoided. Please consult with your doctor regarding appropriate interval between Estramustine and Purified Vi Polysaccharide Typhoid Vaccine.
Severe

Sargramostim (Injection Route)

Do not consume Estramustine from 1 day before until 1 day after taking Sargramostim. Please consult your doctor. Estramustine may reduce efficacy of Sargramostim.
Severe

Lenograstim (Injection Route)

Do not consume Lenograstim from 24 hours before until 24 hours after undergoing cytotoxic chemotherapy. Estramustine may reduce efficacy of Lenograstim.

Frequently asked questions

Xtrant 140mg Capsule belongs to a class of anticancer/cytotoxic drugs called antimicrotubule agents used in the treatment of prostate cancer.

Fact Box

Chemical Class

Estrane steroids

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Other Anticancer Agents

References

  1. Chabner BA, Bertino J, Cleary J, et al. Cytotoxic Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1709.
  2. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Natco Pharma Ltd
Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Xtrant 140mg Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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