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Espazine 1mg Injection

Trifluoperazine (1mg)
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Espazine 1mg Injection is used in the treatment of schizophrenia. It alters the thoughts and elevates the mood, improving the person’s ability to think, feel, and behave.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)
₹24.3 MRP ₹26.348% off 
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Espazine 1mg Injection image
Espazine 1mg Injection image

Product introduction

Espazine 1mg Injection is given as an injection under the supervision of a healthcare professional and should not be self-administered. Take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor and if you have missed a dose, take it as soon as you remember it. Do not skip any doses and finish the full course of treatment even if you feel better. This medication mustn't be stopped suddenly without talking to your doctor as it may worsen your symptoms.

Some common side effects of this injection include dry mouth, abnormality of voluntary movements, urinary retention, constipation, and muscle rigidity. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, rise slowly if you have been sitting or lying down. It may also cause dizziness and sleepiness, do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine can lead to weight gain, have a healthy balanced diet, and exercise regularly. You may also notice some injection site reactions such as pain, redness, or swelling. However, these are temporary and usually resolve on their own. Please consult your doctor in case these do not subside or bother you.

Before taking it, inform your doctor if you are suffering from thyroid or kidney problems, epilepsy, Parkinson’s disease, glaucoma, or any heart problems. You should not take this medicine if you are under the influence of alcohol or any sleep-inducing, cough, and/ or allergy medication. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly.

Uses of Espazine Injection

Benefits of Espazine Injection

Schizophrenia
Schizophrenia is a serious mental health condition that affects how a person thinks, feels, and behaves, often leading to symptoms like hallucinations, delusions, and disorganized thinking. Espazine 1mg Injection helps manage these symptoms by restoring the balance of certain natural substances in the brain. This can improve clarity of thought, reduce false beliefs or perceptions, and support more stable emotional and behavioral responses.

Side effects of Espazine Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Espazine
  • Injection site reactions (pain, swelling, redness)

How to use Espazine Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Espazine Injection works

Espazine 1mg Injection is a typical antipsychotic. It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood.

Quick tips

  • You have been prescribed Espazine 1mg Injection for the treatment of schizophrenia.
  • It may cause less weight gain as compared to other similar medicines.
  • Use caution while driving or doing anything that requires concentration as Espazine 1mg Injection can cause dizziness and sleepiness.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Avoid drinking alcohol while taking this medicine as it can cause increased sedation.
  • Inform your doctor if you experience abnormal movements, particularly of the face, lips, jaw and tongue, while taking this medicine.
  • It may increase your blood sugar and cholesterol level. Eat healthy, exercise regularly and monitor your blood levels regularly.
  • Don't stop taking Espazine 1mg Injection without talking  to your doctor first as it may cause worsening of symptoms.
  • You have been prescribed Espazine 1mg Injection for the treatment of schizophrenia.
  • It may cause less weight gain as compared to other similar medicines.
  • Take it at bedtime to avoid feeling sleepy during the day.
  • Use caution while driving or doing anything that requires concentration as Espazine 1mg Injection can cause dizziness and sleepiness.
  • To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
  • Avoid drinking alcohol while taking this medicine as it can cause increased sedation.
  • Inform your doctor if you experience abnormal movements, particularly of the face, lips, jaw and tongue, while taking this medicine.
  • It may increase your blood sugar and cholesterol level. Eat healthy, exercise regularly and monitor your blood levels regularly.
  • Don't stop taking Espazine 1mg Injection without talking  to your doctor first as it may cause worsening of symptoms.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Espazine 1mg Injection may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Espazine 1mg Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Espazine 1mg Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Espazine 1mg Injection may cause side effects that could affect your ability to drive.
Espazine 1mg Injection make u feel dizzy, drowsy or can cause blurred vision. This may affect your driving ability.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Espazine 1mg Injection in patients with kidney disease. Please consult your doctor.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Espazine 1mg Injection in patients with liver disease.
However, the use of Espazine 1mg Injection is not considered safe in patients with liver disease as per the available data.

Interaction with drugs

Taking Espazine with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Iopamidol (Injection Route)

Do not consume Trifluoperazine 48 hours before and At least 12 hours after consuming Iopamidol.
Life-threatening

Iohexol (Injection Route)

Do not consume Trifluoperazine 48 hours before and At least 24 hours after consuming Iohexol.
Severe

Moxifloxacin (Oral Route)

Do not consume Moxifloxacin with Trifluoperazine. If concurrent use is essential, watch out for symptoms such as muscle spasms, tremors, tiredness, nausea, reduced appetite, palpitations, or numbness. Your doctor may monitor your heart functioning regularly.
Severe

Moxifloxacin (Injection Route)

Do not consume Moxifloxacin with Trifluoperazine. If concurrent use is essential, watch out for symptoms such as muscle spasms, tremors, tiredness, nausea, reduced appetite, palpitations, or numbness. Your doctor may monitor your heart functioning regularly.
Severe

Lithium carbonate (Oral Route)

If concurrent use is essential, watch out for symptoms such as double vision, weakness, dizziness, impaired coordination, or confusion and consult your doctor if you experience them. Your doctor may monitor your ECG frequently and discontinue the medicines if required. Lithium carbonate may reduce blood levels of active form of Trifluoperazine.

Fact Box

Chemical Class

Phenothiazines

Habit Forming

No

Therapeutic Class

NEURO CNS

Action Class

Typical Antipsychotics

References

  1. Stahl SM, editor. Trifluoperazine. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 691-95.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1404.
  3. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Trifluoperazine. [Updated 2018 Oct 31]. [Accessed 20 Feb. 2020] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Glaxo SmithKline Pharmaceuticals Ltd
Address: Dr. Annie Besant Road, Mumbai - 400 030

Vendor Details

Country of origin: India
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