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ENDOTHIK ES 1 MG/25 MG CAPSULE

Capsule
Rs.225for 1 strip(s) (10 capsules each)
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Composition FOR ENDOTHIK ES

Estradiol(1mg),Sildenafil(25mg)

food interaction for ENDOTHIK ES

alcohol interaction for ENDOTHIK ES

pregnancy interaction for ENDOTHIK ES

lactation interaction for ENDOTHIK ES

food
alcohol
pregnancy
lactation
There is no data available. Please consult doctor before consuming the drug.
Taking Sildenafil with alcohol may lower blood pressure.
UNSAFE
Endothik es 1 mg/25 mg capsule is highly unsafe to use during pregnancy.
Human and animal studies have shown significant adverse effects on the foetus. Please consult your doctor.
UNSAFE
Unknown. Human and animal studies are not available. Please consult your doctor.

SALT INFORMATION FOR ENDOTHIK ES

Estradiol(1mg)

Uses

How it works

Estradiol is a form of estrogen, a female sex hormone produced by the ovaries. It acts by replacing the natural hormone in the body when the latter is deficient

Common side effects

Headache, Nausea, Mood changes, Change in body weight, Sexual dysfunction, Breast tenderness, Breast enlargement, Abdominal pain, Metrorrhagia (menstrual bleeding at irregular intervals), Edema, Fibroid
Sildenafil(25mg)

Uses

Sildenafil is used in the treatment of erectile dysfunction and pulmonary hypertension.

How it works

Sildenafil increases blood flow to the penis by relaxing the muscles in penile blood vessels. It helps to get an erection only if the person is sexually stimulated.

Common side effects

Headache, Diarrhoea, Dyspepsia, Flushing (sense of warmth in the face, ears, neck and trunk), Pain in extremity

SUBSTITUTES FOR ENDOTHIK ES

No substitutes found

Top Gynecologists

Expert advice FOR ENDOTHIK ES

  • The drug can cause nausea, vomitting or breast tenderness.
  • Do not use estradiol patches over breast stop taking estradiol and see a doctor immediately if you notice any of the following when taking estradiol:
  • yellowing of your skin or the whites of your eyes (jaundice). 
  • rise in your blood pressure (symptoms may be headache, tiredness, dizziness).
  • new onset migraine-like headaches.
  • pregnancy.
  • signs of a blood clot, such as: painful swelling and redness of the legs, sudden chest pain, difficulty in breathing.
  • Do not consider estradiol alone as a contraceptive. It must be used with progestogen to provide contraceptive benefits.
  • Consult your doctor if you have unusual vaginal bleeding while taking this drug, Immediately consult your doctor if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or changes in vision. This medicine should not be taken for a very long period.
  • Consult your doctor from time to time to check if you still need it.

Frequently asked questions FOR ENDOTHIK ES

Estradiol

Q. Is estradiol and estrogen the same/ is estradiol the same as progesterone/ is estradiol a synthetic hormone/does estradiol valerate work/ what is evalon cream?
Estradiol is the most potent natural estrogen (or “estrogen”) produced by ovaries in female. It is different from another female hormone that is progesterone. It is not a conjugated estrogen and it not a synthetic hormone. Estradiol valerate and Evalon vaginal cream works same as estradiol
Q. Can I take estrogen for polycystic ovary syndrome (PCOS)?
Polycystic ovary syndrome (PCOS) is mainly a result of hormonal disturbance in which there are high levels of male hormones in the body. Oral contraceptive pills containing low dose estrogen and progestogen are commonly prescribed to reduce the levels of endogenous hormone, which helps regularize the menstrual cycle, reduce male hormone levels and decrease acne associated with PCOS. Always consult your doctor before using any medication
Q. What can I take for estrogen dominance?
A balanced diet, exercise, a healthy life style and less exposure to environmental pollutants is what works best to restore the normal hormone balance and reduce estrogen dominance. Your doctor may also start a progesterone therapy, compounds that promote bile secretion, lipotropic formulas (excrete extra estrogen from body), substance which deactivate toxic substances and excess hormones to remove extra estrogen from your body
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Q. What can I take for estrogen deficiency?
For estrogen deficiency, treatment is based on the underlying cause. Your doctor may choose from a variety of medications depending upon your condition for e.g. young or old with menopause, estrogen deficiency or high progesterone levels, etc. You may be given bio-identical estradiol or estriol or counterbalance with natural progesterone in the form of micronized capsules, etc
Q. Can I take estrogen forever?
The length of necessity of hormone therapy varies from person to person and the condition for which it is being treated for
Q. Is estradiol safe/ stop your period/ increase libido/cause constipation/ cause high blood pressure/ make you sleepy/ cause blood clots/ cause insomnia/ cause bloating/ make you emotional?
Estradiol is safe if used at recommended dosage and duration. Estradiol can stop your periods. It may cause high blood pressure and blood clots on long-term use. Other side effects are not confirmed but may occur with some patients. Consult your doctor if you experience one of them
Q. Is estradiol gluten free?
Estradiol preparations are gluten free. However, as the content of excipients differs according to the manufacturer, please refer to the package insert of the particular preparation/brand that you have been prescribed
Q. Is estradiol a conjugated estrogen/ better than Premarin?
Estradiol is a synthetic hormone, whereas Premarin contains conjugated estrogen. Both are different types of estrogen and have comparable benefit and side-effect profile.

Sildenafil

Q. How does sildenafil work?
Sildenafil is a phosphodiesterase inhibitor which acts by relaxing the penile smooth muscles and by increasing the blood flow to the penis. Thus it helps to achieve and maintain an erection but only if there is sexual stimulation. Please consult your doctor before using sildenafil.
Q. Is sildenafil citrate safe?
Sildenafil is a safe drug if it is taken safely provided it is prescribed by a doctor. However, as any other drug, it has its own side effects and drug interactions and hence consultation with a doctor is necessary before taking the drug.
Q. Is sildenafil citrate a steroid?
No, sildenafil is not a steroid. It belongs to a group of medicines called phosphodiesterase inhibitors.
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Q. Is sildenafil banned in India?
No, sildenafil is not banned in India and is available in India only on a doctor's prescription.
Q. Is sildenafil over the counter?
No, sildenafil is not an over-the-counter drug. It can be obtained only on a doctor's prescription.
Q. Is sildenafil generic?
Yes, sildenafil is the generic name of a drug which is a phosphodieterase inhibitor. It is available in the market under different trade names.
Q. Is sildenafil a blood thinner?
No, sildenafil is not a blood thinner. It is a medication used for conditions like erectile dysfunction.
Q. Is sildenafil a prescription drug?
Yes, sildenafil is a prescription drug and can only be taken only when prescribed by the doctor.
Q. Can I take sildenafil for fun?
Sildenafil is a prescription drug and should only be taken for the appropriate indication as prescribed by a doctor as it may be associated with its own side effects. Also, it is available only on prescription by a doctor.
Q. Can I take sildenafil for premature ejaculation?
Sildenafil is not known to affect ejaculation. It is a medication used for erectile dysfunction. Consultation with a doctor is necessary before starting any treatment for premature ejaculation.
Q. Can I take sildenafil for the rest of my life?
No, sildenafil is a prescription drug and should only be taken at the appropriate dose for the appropriate duration as per the doctor's advice.
Q. Can I take sildenafil in my twenties?
Sildenafil is indicated for adult men above the age of 18 who have erectile dysfunction. It should be taken only when advised by a doctor.
Q. Can I take sildenafil with alcohol?
Sildenafil is not known to have any clinically meaningful effect when taken after consuming moderate amounts of alcohol. However, consult your doctor before taking them together.
Q. Can I take sildenafil with food?
Food can delay the absorption (time to reach the blood) of sildenafil. The onset of action can be delayed if taken with or after food, especially a high-fat diet. Please consult your doctor.
Q. Can I take sildenafil with dapoxetine?
Sildenafil is not known to have any clinically relevant effect when taken with dapoxetine. However, consult your doctor before taking both the medications together.
Q. Can I take sildenafil with tadalafil?
Sildenafil and tadalafil belong to the same group of drugs called phosphodiesterase inhibitors. As they are similar in action and have similar uses, they should not be taken together. Please consult your doctor.
Q. Can I take sildenafil with warfarin?
No clinically relevant interactions have been observed when sildenafil is taken with warfarin. However, interactions may occur. Please consult your doctor before taking both the drugs together.
Q. Can I take sildenafil with high blood pressure?
Sildenafil may lower blood pressure. In patients who are taking antihypertensive (blood pressure lowering) medicines for high blood pressure, taking sildenafil may cause decrease the blood pressure significantly. Please consult your doctor for taking sildenafil if you are having high blood pressure and you are taking medicines for the same.
Q. Can I take sildenafil with lisinopril?
Sildenafil may increase the blood-pressure-lowering effect of lisinopril. Consult your doctor before taking both the two medicines together.
Q. Can I take sildenafil with ramipril?
Sildenafil may increase the blood-pressure-lowering effect of ramipril. Consult your doctor before taking both the two medicines together.
Q. Can I take sildenafil with beta blockers?
Sildenafil may increase the blood-pressure-lowering effect of beta-blockers. Consult your doctor before taking both the drugs together.
Q. Can I take sildenafil with amlodipine?
Sildenafil may increase the blood-pressure-lowering effect of amlodipine. Consult your doctor before taking both the drugs together.
Q. Does sildenafil citrate affect fertility?
No, sildenafil is not known to affect fertility. It is used only for erectile dysfunction. For treatment of any fertility-related problems, please consult a doctor.
Q. Does sildenafil affect sperm?
Sildenafil is not known to affect sperm (number or movement of sperms). It is a drug which is used for erectile dysfunction.
Q. Does sildenafil work in females?
Sildenafil is not indicated for use in women. It is indicated for adult men with erectile dysfunction.
Q. Does sildenafil increase blood pressure?
No, sildenafil is not associated with an increase in blood pressure. It can cause a decrease in blood pressure especially if taken with other blood-pressure-lowering medications. Please consult your doctor before taking sildenafil with any other medicine.
Q. Does sildenafil delay ejaculation?
No, sildenafil is not known to affect ejaculation.
Q. Does sildenafil expire?
Sildenafil like any other medicine has an expiry date and should not be used beyond the date mentioned on the package.
Q. How long will sildenafil stay in my system?
After oral administration of sildenafil, it stays in the system for 4 hours and its effect will be for 4 to 6 hours (up to a maximum of 12 hours).
Q. How many times can I take sildenafil in a day and when does it start to work?
Sildenafil is to be taken only one time in a day before the sexual activity. It starts to work within 30-60 minutes after taking it and can be taken maximum upto 4 hours before the sexual activity.
Q. Why does sildenafil cause a fall in blood pressure (hypotension)?
Sildenafil has the property of relaxing the smooth muscle of the blood vessels and widening them which can cause a fall in blood pressure (hypotension). So, when used with blood pressure lowering drugs or nitrates, it can cause a severe fall in blood pressure, which could be fatal. Sildenafil should not be taken if you are taking nitrates for chest pain or you have a history of heart attack or stroke in the past six months.
Q. What are sildenafil citrate sublingual tablets?
Sildenafil sublingual tablets start to act within 15 minutes with lesser dose compared to oral tablets which take almost 30 minutes to 1 hour to achieve the same effect. These are not taken with water. Sublingual tablets dissolve under the tongue, get absorbed and directly reaches the blood stream and act much faster compared to the oral tablets. These are developed to avoid the breakdown of the medicine in stomach and liver before reaching the blood circulation.
Q. Is sildenafil safe to use in patients with diabetes?
Yes, sildenafil is safe to use in patients with diabetes. Diabetes is one most common causes of erectile dysfunction and is commonly reported by these patients. Long standing diabetes mellitus can damage the nerves in the body (neuropathy) including the nerves of the penis. It also harden and narrow the blood vessels which decreases the blood flow to the penis causing erectile dysfunction. Sildenafil is seen to be beneficial in treating erectile dysfunction (ED) in patients with diabetes mellitus.
Q. Why is the use of sildenafil contraindicated with nitrates?
Use of sildenafil is not recommended in patients taking nitrates (organic nitrates or organic nitrites) as their combined use can cause a severe fall in blood pressure, which can also result in death. It is advisable to keep a time gap of 24 hours between the intake of sildenafil and any nitrate substance.
Q. Can women use sildenafil?
Sildenafil is indicated for use in women for the treatment of pulmonary arterial hypertension (PAH). However, it is not recommended in women of childbearing age group.
Q. What are the serious side effects of sildenafil?
Sildenafil can cause serious side effects like heart attack, sudden cardiac death, abnormal heart beat and bleeding in the brain tissues that can cause temporary or permanent brain damage. A patient can have chest pain during the intercourse and if this occurs, try to relax in a semi-sitting position and do not use any nitrate to relieve the chest pain. Rarely a sudden loss in vision and serious allergic skin reactions with fever, peeling and swelling of the skin, blistering of the mouth, genitals and around the eyes can occur.
Q. What is the difference between sildenafil and lodenafil?
Both sildenafil and lodenafil are phosphodiesterase-5 (PDE5) inhibitors and are used for the treatment of erectile dysfunction. Sildenafil is more effective and more potent than lodenafil which is relatively a newer molecule. There is not much data available on the side effects of lodenafil as of now.
Q. Can I take sildenafil for treating piles (hemorrhoids)?
No, sildenafil is not indicated for the treatment of piles (hemorrhoids). Rather, its use has been reported to cause piles (hemorrhoids).
Q. Where is sildenafil absorbed?
Sildenafil undergoes rapid absorption in the intestine. However, only 40% of the drug reaches the blood in its active form because of its breakdown in the gut wall and liver before reaching there.
Q. Is sildenafil also given by injectable route (intravenous/IV) route?
Sildenafil can be given by intravenous (i.v.) route in the management of pulmonary arterial hypertension (PAH) and not in the treatment of erectile dysfunction (ED). The injectable form is used in patients already taking oral sildenafil or those patients who are unable to take the drug orally.
Q. Can sildenafil be taken with losartan?
Yes, sildenafil can be taken along with losartan. However, there could be an excessive fall in blood pressure when taken together and you can experience symptoms like dizziness, lightheadedness, fainting, flushing, headache, or an increased heart rate. So, special caution must be taken when taking both the drugs together and inform your doctor if you experience any of these symptoms.
Q. Can I take sildenafil with paracetamol?
Yes, sildenafil can be taken with paracetamol. No drug-drug interactions or any harmful effects have been reported when they are used together.
Q. Can I take sildenafil with aspirin?
Yes, sildenafil can be taken with aspirin. No drug-drug interactions or any harmful effects have been reported when they are used together.

TOP MEDICINES PRESCRIBED WITH ENDOTHIK ES 1 MG/25 MG CAPSULE

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Content on this page was last updated on 10 April, 2017, by Dr. Varun Gupta (MD Pharmacology)