Duodopa 250mg/25mg Tablet is a combination of two medicines used to treat Parkinson’s disease. It is one of the most effective medications to relives symptoms of Parkinson’s disease such as tremors, muscle stiffness, and difficulty moving.

Duodopa 250mg/25mg Tablet can be taken without food but it is better to avoid a high protein diet and dairy products while taking this medicine. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor and if you have missed a dose, take it as soon as you remember it. You should never skip any doses and try to finish the full course of treatment even if you feel better. Do not stop taking medicine until told by your doctor as it can cause harmful effects.

This medicine may cause side effects like nausea, vomiting, dryness in the mouth, sweating, and headache. Initially, this medicine may cause a sudden drop in blood pressure when you change positions, so it's better to rise slowly if you have been sitting or lying down. It causes a sudden onset of dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.

Take caution while taking medicine if you are suffering from liver or kidney disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Uses of Duodopa Tablet

Treatment of Parkinson's disease

Benefits of Duodopa Tablet

In Treatment of Parkinson's disease

Duodopa 250mg/25mg Tablet is one of the most effective medications to relieve symptoms of Parkinson's disease such as tremors, muscle stiffness, and difficulty moving. It increases the amount of a chemical called dopamine in the brain which helps in the coordination of body movements. This medicine can therefore enhance the quality of life by improving the ability to carry out daily functions in a better manner.

Side effects of Duodopa Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Duodopa

Dryness in mouth
Dizziness
Headache
Abnormal dreams
Involuntary muscle movement
Gastrointestinal disturbance
Sweating

How to use Duodopa Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Duodopa 250mg/25mg Tablet is to be taken empty stomach.
Avoid Duodopa 250mg/25mg Tablet with high protein meals such as cottage cheese, Swiss cheese, protein powder, eggs and milk.

How Duodopa Tablet works

Duodopa 250mg/25mg Tablet is a combination of two medicines: Levodopa and Carbidopa which treats Parkinsonism. Levodopa is a dopamine precursor which gets converted to dopamine, a chemical messenger that controls movement in the brain. Carbidopa is a peripheral decarboxylase inhibitor which prevents breakdown of levodopa allowing it to enter the brain and increase dopamine levels.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Duodopa 250mg/25mg Tablet.

Pregnancy

CONSULT YOUR DOCTOR

Duodopa 250mg/25mg Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

SAFE IF PRESCRIBED

Duodopa 250mg/25mg Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Partial to complete suppression of lactation was seen in mothers on the treatment with Duodopa 250mg/25mg Tablet, but when the treatment was stopped, lactation returned to normal levels.

Driving

UNSAFE

Duodopa 250mg/25mg Tablet may cause side effects which could affect your ability to drive.
As Duodopa 250mg/25mg Tablet may cause dizziness, drowsiness, double vision, which may affect your ability to react which may affect your ability to drive.

Kidney

SAFE IF PRESCRIBED

Duodopa 250mg/25mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Duodopa 250mg/25mg Tablet may not be needed in these patients. Please consult your doctor.

Liver

CAUTION

Duodopa 250mg/25mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Duodopa 250mg/25mg Tablet may be needed. Please consult your doctor.

What if you forget to take Duodopa Tablet?

If you miss a dose of Duodopa 250mg/25mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Duodopa 250mg/25mg Tablet

₹3.07/Tablet

Syndopa 275 Tablet

Sun Pharmaceutical Industries Ltd

₹4.9/tablet

60% costlier

Tidomet Forte Tablet

Torrent Pharmaceuticals Ltd

₹4.7/tablet

53% costlier

LCD 275 Tablet

Intas Pharmaceuticals Ltd

₹4.95/tablet

61% costlier

Syndopa Forte Tablet

Sun Pharmaceutical Industries Ltd

₹4/tablet

30% costlier

Syndopa 275 Tablet

Sun Pharmaceutical Industries Ltd

₹4/tablet

30% costlier

Quick tips

You have been prescribed Duodopa 250mg/25mg Tablet to treat your symptoms of Parkinson's disease.
Reduce/avoid a high-protein diet (e.g. meat, poultry, and dairy products) while you are taking the medicine as it can reduce the amount of medication absorbed by your body.
Be cautious while driving or doing anything that requires concentration as Duodopa 250mg/25mg Tablet can make you very sleepy.
When you start the medication, get out of bed slowly, as the medication may cause dizziness, lightheadedness or fainting.
Do not stop taking the medication without talking to your doctor. It may result in a serious syndrome that causes fever, stiff muscles, unusual body movements, sweating, and confusion.
Talk to your doctor in case you develop hallucinations or other changes in your behavior.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

Patient concerns

Parkinson's disease tremors ,Insomnia.

Dr. Ravi Shankar M.

Ayurveda

Use Dhanadanayanadi kashayam 15ml twice a day with 15 ml water before food and Zandopa 10 grams twice a day witk milk after food and Tab Dhanvantari Vati 1-0-1 after food for 2 months

Parkinson's disease for 25 yrs. Taking allopathy Suggestions needed

Dr. Deepak Kumar Soni

Ayurveda

Kindly consult to any good Ayuvedic Panchkarma center. Panchkarma therapy will give you some result .

My father has parkinson's disease from last 12 year. In last 2012 he got severe pneumonia and has been admitted in AIIMS .He was treated with various antibiotics.he came out but got bed ridden after that.From last few year he just sit on his own. he is currently taking bexol 1mg three times, syndopa 125 plus 3 times, ropark XL 3 times.now from few year he got hallucination and cound not sleep in night and constantly talking in night(Some Nights not always).During his stay in AIIMS Dr. prescribed quetiapine 12.5 mg which he is not currently taking.please advice some medicien so that he atleast can sleep at night.

Dr. Vikas Sharma

Neurology

Start Oleanz 2.5 mg at nite

FAQs

What is Duodopa 250mg/25mg Tablet?

Duodopa 250mg/25mg Tablet is a combination of two medicines: Levodopa and Carbidopa. This medication is used to treat the symptoms of Parkinson's disease like tremors (shaking), stiffness and slowness of movement. These symptoms are caused due to the lack of dopamine, a natural substance usually found in the brain. Levodopa works by being converted to dopamine in the brain. Carbidopa works by preventing levodopa from being broken down before it reaches the brain. By increasing the amount of dopamine in the brain, Duodopa 250mg/25mg Tablet helps control the symptoms of Parkinson’s disease and helps you to perform daily activities such as dressing, walking, handling utensils, etc.

Can I stop taking Duodopa 250mg/25mg Tablet when my symptoms are relieved?

No, you should continue to take Duodopa 250mg/25mg Tablet, even if you feel well. Do not stop taking Duodopa 250mg/25mg Tablet without talking to your doctor. If you suddenly stop taking Duodopa 250mg/25mg Tablet, you could develop a serious problem causing fever, rigid muscles, unusual body movements and confusion. Consult your doctor if the symptoms are relieved, he might decrease your dose gradually.

Can the Duodopa 250mg/25mg Tablet cause sleepiness or drowsiness?

Duodopa 250mg/25mg Tablet may make you drowsy or may cause you to suddenly fall asleep during your daily activities. You might not feel drowsy or notice any other warning signs before suddenly falling asleep. Avoid driving a car, operating machinery, working at heights or participating in potentially dangerous activities at the beginning of your treatment until you know how the medication affects you. If you suddenly fall asleep while doing something such as watching television, talking, eating, or riding in a car, or if you become very drowsy, especially during the daytime, call your doctor.

Can the Duodopa 250mg/25mg Tablet cause dark urine?

Yes, it is a rare side effect. Consumption of Duodopa 250mg/25mg Tablet may alter the colour of your saliva, urine or sweat and make it dark colored (red, brown or black). This is harmless but your clothing may become stained.

What are the instructions for storage and disposal of Duodopa 250mg/25mg Tablet?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

How long does Duodopa 250mg/25mg Tablet take to cure Parkinson’s disease?

Duodopa 250mg/25mg Tablet controls Parkinson's disease but does not cure it. It may take several months before you feel the full benefit of Duodopa 250mg/25mg Tablet.

Can I take a higher than the recommended dose of this medication?

No, taking a higher than the recommended dose of Duodopa 250mg/25mg Tablet can lead to increased chances of side effects and toxicity. Talk to your doctor if your symptoms do not improve after a few weeks of treatment. Also let your doctor know if the effects of this medication seem to wear off quickly in between doses.

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References

MedlinePlus. Levodopa + Carbidopa. [Accessed 23 Apr. 2019] (online) Available from:
MedIndia. Levodopa+Carbidopa. [Accessed 23 Apr. 2019] (online) Available from:
Carbidopa and Levodopa Extended-Release [Patient Information Sheet]. Ahmedabad, Gujarat: TORRENT PHARMACEUTICALS LTD. [Accessed 28th Sept. 2023] (online) Available from:

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