Dextodine 50 Injection

Dexmedetomidine (100mcg/ml)

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Dextodine 50 Injection is a prescription medicine used to provide sedation (a state of calm, drowsiness, or sleep) for adult patients in intensive care settings. It may also be used for awake sedation during diagnostic and surgical procedures.

Written By Dr. Swati Mishra, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 19 Dec 2025 | 12:56 PM (IST)

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General Information

Contains

Dexmedetomidine (100mcg/ml)

Marketer

Biogen Serums Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Dextodine 50 Injection is given as an infusion (drip) into a vein under the supervision of a healthcare professional. It is important to inform your doctor if you are suffering from any medical conditions like slow heart rate, low blood pressure, neurological disorder, severe liver problems, or have ever developed a serious fever after some medicines, especially after taking anesthesia. Your doctor will monitor the cardiac and respiratory state after providing this injection.

Common side effects of this medicine include dryness in the mouth, decreased blood pressure, and slow heart rate. Consult your doctor if these side effects do not improve with time or worsen. They may be able to suggest ways to prevent or reduce the side effects.

Uses of Dextodine Injection

Sedative

Benefits of Dextodine Injection

Sedative
Dextodine 50 Injection is used to help calm and sedate patients, especially in intensive care or during surgical procedures. It provides sedation without causing significant breathing problems, making it safer in controlled settings. It also helps reduce anxiety and discomfort while ensuring the patient remains relaxed.

Side effects of Dextodine Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Dextodine

Slow heart rate
Dryness in mouth
Decreased blood pressure

How to use Dextodine Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Dextodine Injection works

Dextodine 50 Injection works by modulating the action of certain chemical messengers in the brain that relieves pain and induces sleep.

Quick tips

Dextodine 50 Injection is given as an infusion into the veins by healthcare professionals only.
Your doctor will closely monitor your heart rate, blood pressure, breathing rate and oxygen level during the treatment.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Dextodine 50 Injection may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Dextodine 50 Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Dextodine 50 Injection may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

NOT RELEVANT

Not relevant, as Dextodine 50 Injection is intended for use in hospitalized patients.

Kidney

SAFE IF PRESCRIBED

Dextodine 50 Injection is safe to use in patients with kidney disease. No dose adjustment is recommended.

Liver

CAUTION

Dextodine 50 Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Interaction with drugs

Taking Dextodine with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Mild

Digoxin (Oral Route)

Monitor your heart rate regularly and talk to your doctor if you notice persistently low heart rate.

Mild

Digoxin (Injection Route)

Monitor your heart rate regularly and talk to your doctor if you notice persistently low heart rate.

Frequently asked questions

What is Dextodine 50 Injection used for?

Dextodine 50 Injection is used to provide sedation (a state of calm, drowsiness, or sleep) for adult patients in intensive care settings (i.e. in initially intubated and mechanically ventilated patients or non-intubated patients prior to and/or during surgical and other procedures).

Is Dextodine 50 Injection a controlled substance?

Dextodine 50 Injection is a sedative that belongs to a class of drugs called centrally active selective 2A agonists.It is not a controlled drug/substance

Is Dextodine 50 Injection approved by FDA?

Yes, Dextodine 50 Injection approved by FDA

Does Dextodine 50 Injection cause amnesia?

Dextodine 50 Injection is given as an infusion (drip) into veins. It may cause pain at the injection site and low heart rate (bradycardia). It does not cause amnesia.

How does Dextodine 50 Injection work?

Dextodine 50 Injection activates the central 2A receptors which causes sedation and analgesia.

Fact Box

Chemical Class

O- xylenes

Habit Forming

Therapeutic Class

NEURO CNS

Action Class

Centrally Acting Alpha-2 Agonist- Sedative Agents

References

Stahl SM, editor. Dextromethorphan. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 181-83.
Patel PM, Patel HH, Roth DM. General Anesthetics and Therapeutic Gases. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 548-49.
Biaggioni I, Robertson D. Adrenoreceptor Agonists & Sympathomimetic Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 140, 145.
Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 381-82.
Dexmedetomidine hydrochloride. Lake Forest, Illinois: Hospira, Inc.; 1999 [revised Jun. 2013]. [Accessed 12 Feb. 2019] (online) Available from:
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Dexmedetomidine. [Updated 2018 Dec 3]. [Accessed 20 Feb. 2020] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). [Accessed 22 Mar. 2019] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Biogen Serums Pvt Ltd
Address: R6 Sector, A 104, Life Republic Marunji, Hinjewadi - 411057

Vendor Details

Country of origin: India

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