Destres 0.25mg/3mg Tablet

Alprazolam (0.25mg)+ Melatonin (3mg)

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Destres 0.25mg/3mg Tablet is used to treat insomnia. It helps to calm the brain by decreasing the abnormal and excessive activity of the nerve cells. It also regulates the sleep cycle and helps the patient to fall asleep quickly.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 29 Oct 2026 | 12:23 PM (IST)

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General Information

Contains

Alprazolam (0.25mg)+ Melatonin (3mg)

Marketer

Ethix Healthcare

Storage

Store below 30°C

The content is shown in English

Product introduction

Destres 0.25mg/3mg Tablet should be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor as it has high habit-forming potential. However, take it as advised by your doctor because it is not recommended for long-term use. Inform your doctor if you are suffering from any liver or kidney problems before taking this medicine. You should avoid smoking and alcohol while using this medicine. Regular monitoring of blood sugar levels is required while taking this medicine.

Some common side effects of this medicine include confusion, tiredness, and memory impairment. It may also cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. It may cause weight gain or weight loss depending upon person to person. To prevent weight gain, you can eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly. However, weight loss can be managed by consulting a dietitian who can help you in increasing your food portions.

Take caution while taking medicine if you are suffering from liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.

Uses of Destres Tablet

Treatment of Insomnia

Benefits of Destres Tablet

Treatment of Insomnia
Destres 0.25mg/3mg Tablet is a combination of two medicines that helps treat insomnia (difficulty falling or staying asleep) in people who have problems related to their sleeping habits. Insomnia may cause you to wake up earlier than usual and you may find it difficult to go back to sleep. It works by slowing down the abnormal activity of nerves in the brain to allow sleep. It also improves the sleep-wake cycle and restores it to normal. This helps you relax, feel calm, and more energetic. It also helps you concentrate better and improves your quality of life.

Side effects of Destres Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Destres

Confusion
Drowsiness
Tiredness
Uncoordinated body movements
Depression
Memory impairment

How to use Destres Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Destres 0.25mg/3mg Tablet may be taken with or without food.

How Destres Tablet works

Destres 0.25mg/3mg Tablet contains alprazolam and melatonin. Alprazolam enhances the action of GABA, a chemical messenger that reduces activity in the brain and produces a calming effect. Melatonin is a hormone that helps regulate the body's internal clock and sleep-wake cycle.

Quick tips

Destres 0.25mg/3mg Tablet is prescribed for the treatment of insomnia.
It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
Do not stop taking Destres 0.25mg/3mg Tablet unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
Inform your doctor if you have liver disease.
Inform your doctor if you are pregnant or breastfeeding.
Destres 0.25mg/3mg Tablet is prescribed for the treatment of insomnia.
It can take a week or two after starting this treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.
Do not stop taking Destres 0.25mg/3mg Tablet unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.
Inform your doctor if you have liver disease.
Inform your doctor if you are pregnant or breastfeeding.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Destres 0.25mg/3mg Tablet

Pregnancy

CONSULT YOUR DOCTOR

Destres 0.25mg/3mg Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CONSULT YOUR DOCTOR

Destres 0.25mg/3mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Destres 0.25mg/3mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Destres 0.25mg/3mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

UNSAFE

Destres 0.25mg/3mg Tablet is unsafe to use in patients with liver disease and should be avoided.
There is very limited experience on use of Destres 0.25mg/3mg Tablet in patients with underlying liver disease.

Frequently asked questions

What is Destres 0.25mg/3mg Tablet used for?

Destres 0.25mg/3mg Tablet can be used to manage insomnia, jet lag and short term anxiety as it may help provide a calming and sedative effect.

What is the correct way to take Destres 0.25mg/3mg Tablet?

Destres 0.25mg/3mg Tablet can be taken with or without food usually at a fixed time each day. The exact duration and dose will be decided by your doctor. Do not increase the dose or take additional doses if you are unable to sleep.

Can Destres 0.25mg/3mg Tablet help me fall asleep faster?

Destres 0.25mg/3mg Tablet has a sedative effect that regulates sleep cycle and helps brain to calm down that induces faster sleep. However, the degree of benefit depends on the underlying sleep problem and the individual condition.

Can Destres 0.25mg/3mg Tablet be used for jet lag?

Destres 0.25mg/3mg Tablet may help with sleep timing problems associated with jet lag in some circumstances if advised by the doctor.

Can I take Destres 0.25mg/3mg Tablet to treat my anxiety?

Destres 0.25mg/3mg Tablet may be prescribed by the doctor to manage short term anxiety but it is not treat anxiety related disorders. Consult a doctor and get yourself evaluated if you think you have anxiety issues.

Am I becoming dependent on Destres 0.25mg/3mg Tablet?

Yes, Destres 0.25mg/3mg Tablet may cause dependence and carries risks of misuse and addiction, even when taken as prescribed. The risk may increase with prolonged use or higher doses. Use it only under medical supervision and exactly as advised.

Can I take Destres 0.25mg/3mg Tablet with other sleeping pills or medicines that cause drowsiness?

Do not combine it with other sedatives or sleeping medicines unless specifically advised by the doctor for your health condition. Combining it with medicines that cause central nervous system depression can increase sedation and may cause serious breathing problems.

Can Destres 0.25mg/3mg Tablet affect memory or concentration?

Yes. Destres 0.25mg/3mg Tablet can impair memory, attention and coordination. Avoid activities that require your full alertness like driving, operating heavy machinery etc. if you feel sleepy.

What should I do if I take more than the prescribed dose of Destres 0.25mg/3mg Tablet?

Seek urgent medical advice if you take more than prescribed, especially if you experience extreme sleepiness, confusion, poor coordination or slow or difficult breathing. Do not combine an extra dose with alcohol or other sedatives.

Is Destres 0.25mg/3mg Tablet suitable for long-term treatment of insomnia?

Long term use of Destres 0.25mg/3mg Tablet can cause dependence and withdrawal, and ongoing sleep difficulties require treatment of the underlying cause that may need a different management approach rather than relying alone on the medication. Include mindfulness activities, brain calming methods, and follow a discipline routine to help improve your overall lifestyle and sleep cycle.

Fact Box

Habit Forming

Yes

Therapeutic Class

NEURO CNS

References

User feedback

What are you using Destres Tablet for?

Insomnia

100%

How much was the improvement?

Excellent

67%

Average

33%

What were the side-effects while using Destres 0.25mg/3mg Tablet?

No Side Effect

100%

How do you take Destres Tablet?

With food

100%

Please rate Destres 0.25mg/3mg Tablet on price

Expensive

100%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Ethix Healthcare
Address: 94, 4th avenue, sundar nagar, guindy, chennai, 600032, tamil nadu, india

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Home

Neuro Cns

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Destres 0.25mg/3mg Tablet

Destres 0.25mg/3mg Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Destres Tablet

Benefits of Destres Tablet

Side effects of Destres Tablet

How to use Destres Tablet

How Destres Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Destres 0.25mg/3mg Tablet used for?

What is the correct way to take Destres 0.25mg/3mg Tablet?

Can Destres 0.25mg/3mg Tablet help me fall asleep faster?

Can Destres 0.25mg/3mg Tablet be used for jet lag?

Can I take Destres 0.25mg/3mg Tablet to treat my anxiety?

Am I becoming dependent on Destres 0.25mg/3mg Tablet?

Can I take Destres 0.25mg/3mg Tablet with other sleeping pills or medicines that cause drowsiness?

Can Destres 0.25mg/3mg Tablet affect memory or concentration?

What should I do if I take more than the prescribed dose of Destres 0.25mg/3mg Tablet?

Is Destres 0.25mg/3mg Tablet suitable for long-term treatment of insomnia?

Fact Box

Habit Forming

Therapeutic Class

References

User feedback

What are you using Destres Tablet for?

How much was the improvement?

What were the side-effects while using Destres 0.25mg/3mg Tablet?

How do you take Destres Tablet?

Please rate Destres 0.25mg/3mg Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

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