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Written By
BCMAS, Pharm.D
Reviewed By
MBA, MD (Pharmacology)
Last updated on:
28 Nov 2018 | 10:42 AM (IST)
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Depline Plus 12.5 mg/5 mg Tablet


Overview

Uses of Depline Plus Tablet

Depline Plus Tablet side effects

Common
  • Constipation
  • Difficulty in urination
  • Weight gain
  • Confusion
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Tiredness
  • Blurred vision
  • Dryness in mouth
  • Increased heart rate
  • Uncoordinated body movement
  • Depression
  • Memory impairement

How to use Depline Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depline Plus 12.5 mg/5 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Depline Plus Tablet works

Depline Plus 12.5 mg/5 mg Tablet is a combination of two medicines: Amitriptyline and Chlordiazepoxide, which treats depression. Amitriptyline is a tricyclic antidepressant which increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression. Chlordiazepoxide is a benzodiazepine (BZD) which works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.

Depline Plus Tablet related warnings

Alcohol
CAUTION
Depline Plus 12.5 mg/5 mg Tablet may cause excessive drowsiness with alcohol.
Pregnancy
WEIGH RISKS VS BENEFITS
Depline Plus 12.5 mg/5 mg Tablet is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Lactation
CAUTION
Depline Plus 12.5 mg/5 mg Tablet is probably unsafe to use during lactation. Limited human data suggest that the drug could represent a significant risk to the baby.
Driving
Do not drive unless you are feeling well.
As Depline Plus 12.5 mg/5 mg Tablet may make you feel drowsy or affect your concentration and this may affect your ability to drive.
Kidney
Depline Plus 12.5 mg/5 mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Depline Plus 12.5 mg/5 mg Tablet may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Depline Plus 12.5 mg/5 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Depline Plus 12.5 mg/5 mg Tablet may be needed. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Depline Plus 12.5 mg/5 mg Tablet
₹1.85/Tablet
₹2.73/Tablet
48% costlier
Amixide-H Tablet
Sun Pharmaceutical Industries Ltd
₹3.6/Tablet
95% costlier
₹3.28/Tablet
78% costlier
Aculip H 12.5 mg/5 mg Tablet
Shine Pharmaceuticals Ltd
₹3.02/Tablet
64% costlier
Amitone Plus Tablet
Intas Pharmaceuticals Ltd
₹2.9/Tablet
57% costlier

Patient Concerns

Questions Related to Depline Plus

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??? ???? ??? ???? ???? ?? ?? ?????? ??? ?? ???? ???? ?? Patricia plus 12.5 ?? amazeo 50 ?? ??? ??? ?? ?? ????? ??? ?? ???? ???? ?? ??? ??? ??? ???????? ???? ?? ???? ??? ???
Dr. Jyoti Kapoor Madan
Psychiatrist
Based on your clinical history, your doctor plans the type of medicine and it's dose and duration. For first episode of anxiety/ depression/ panic, the usual maintenance phase is 6 months of asymptomatic period, after which medicines can be gradually tapered. But treatment may need to continue longer depending on severity and frequency of episodes. To monitor any potential side effects and to take any decision to change medication or stop them, several factors have to be taken in account for which regular follow up with your psychiatrist is important. For second opinion, seek a proper consultation with another psychiatrist and take along your previous prescriptions.
Sir i have taken the medicine of depression tablet ventab 25 mg prponol 10 mg nixodre plus i am feeling very tired and i wanted to concieved as soon as possoble is it write please give advice aboit this. When i have to try to conceive does any side effect on baby please suggest me i have taken these medicine from 3 to 4 month but there is no any improment y health how to overcome from this problem please reply me
Dr. Jyoti Kapoor Madan
Psychiatrist
You shouldn't plan pregnancy while you are on psychotropics, they can harm the foetus, especially during the first three months of conception. Pregnancy can also increase the risk to increasing depression. A reasonable solution is to get adequate treatment and go for psychotherapy, after you have recovered from depression, gradually withdraw medicines and continue therapy before planning conception. For further guidance, visit your psychiatrist.
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FAQs

Q. What are the instructions for storage and disposal of Depline Plus?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Are there any important warnings associated with use of Depline Plus?

During the first few months of treatment, Depline Plus may increase suicidal thoughts or actions in some patients. Patients having mood or behavioral disorder have a high risk of developing suicidal thoughts and actions. You should pay close attention and report your doctor of any such behavior or mood changes. Make sure that you visit the doctor for the scheduled follow-up appointments.

Q. Can I stop taking Depline Plus when my symptoms are relieved?

No, you should continue to take Depline Plus, even if you feel well. If you stop Depline Plus suddenly, serious withdrawal symptoms may occur. Consult your doctor if the symptoms are relieved, he might decrease your dose gradually.

Q. How to manage weight gain associated with the use of Depline Plus?

There are reports which suggest that the use of Depline Plus can cause weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight. An important to remember is that it is easier to prevent weight gain than losing increased weight.

Q. Can the use of Depline Plus cause sleepiness?

Yes, Depline Plus can make you feel sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities till you know how this medicine affects you.

Q. Can the use of Depline Plus affect my sexual life?

The use of Depline Plus can affect the sexual life of both men and women. Most commonly caused problems are decreased sexual desire, erectile dysfunction (inability to develop or maintain erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort while having sex. If you experience these problems, discuss with your doctor.

Q. Can I drink alcohol while taking Depline Plus?

No, do not drink alcohol while you are taking Depline Plus. Drinking alcohol can increase the severity of drowsiness or sleepiness caused by Depline Plus.

Q. Can the use of Depline Plus change the color of urine?

Yes, Depline Plus can the change the color of the urine to blue or green. This change of color is expected while using Depline Plus, and it is not harmful. Your urine color becomes normal once you stop taking Depline Plus.

Q. How long does Depline Plus take to work?

Everybody responds differently to the treatment. In general, it can take several weeks to feel the full benefits of Depline Plus, although some people will start to feel better sooner. When taking Depline Plus, it is important to give it time to work.

Related Products

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Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. DailyMed. Chlordiazepoxide and amitriptyline hydrochloride. [Accessed 10 Apr. 2019] (online) Available from:External Link
  2. Amitriptyline. North Harrow, Middlesex: Accord Healthcare Limited; 2018. [Accessed 10 Apr. 2019] (online) Available from:External Link
  3. MedlinePlus. Chlordiazepoxide. [Accessed 10 Apr. 2019] (online) Available from:External Link
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