



Denoci Injection
Product Summary :
Denoci Injection is a monoclonal antibody containing denosumab used to treat osteoporosis in postmenopausal women and men at increased risk of fractures. It helps slow down bone breakdown, making bones stronger and reducing the risk of fractures. It is given as an injection under the skin once every 6 months. The doctor may advise calcium and vitamin D supplements during treatment. Common side effects include back pain, pain in the arms or legs, and muscle or bone pain. Do not stop or delay treatment without consulting your doctor, as this may increase the risk of fractures. Tell your doctor if you have kidney disease, especially if you are on dialysis, as Denoci Injection can cause severely low blood calcium levels.Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 04 Oct 2026 | 01:01 AM (IST)
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Product expires after May, 2027
Expiry date may vary by batch. All batches have a 3-month shelf life from the date of dispatch.
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General Information





Product introduction
Denoci Injection is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. To make it more effective, take adequate amount of calcium and vitamin D supplements while on treatment with this medicine.
Some common side effects of this medicine include pain in extremity, musculoskeletal pain, nerve pain, urinary tract infection, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.
To make sure the medicine is safe for you, before taking it, let your doctor know of all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before using this medicine.
There is a Patient Support Program / Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details.
Uses of Denoci Injection
- Treatment of Osteoporosis : Helps slow down bone breakdown, making bones stronger and reducing the risk of fractures in postmenopausal women and men at increased risk of fractures.
Benefits of Denoci Injection
Osteoporosis is a condition in which the bones become weak and are more likely to break. Denoci Injection is used to treat osteoporosis in postmenopausal women and men at increased risk of fractures and can also help manage bone loss associated with long-term glucocorticoid treatment. It slows down bone breakdown and increases bone strength and density. This helps reduce the risk of fractures, including fractures of the spine, hip, and other bones.
Side effects of Denoci Injection
- Back pain
- Pain in extremities
- Hypercholesterolemia (high cholesterol)
- Musculoskeletal (bone, muscle or joint) pain
- Cystitis
- Pancreatic inflammation
- Joint pain
- Nasopharyngitis (inflammation of the throat and nasal passages)
- High blood pressure
- Bronchitis (inflammation of the airways)
- Headache
How to use Denoci Injection
How Denoci Injection works
Dosage
Denoci Injection is given as an injection under the skin once every 6 months, usually in the upper arm, thigh, or abdomen. The duration of treatment will depend on your condition and response to treatment. Your doctor will periodically assess whether you need to continue it. Adequate calcium and vitamin D should be taken during treatment as advised by your doctor. Do not stop or delay treatment without consulting your doctor.
All substitutes for Denoci Injection
Quick tips
- Take calcium and vitamin D supplements as advised by your doctor to help maintain normal calcium levels during treatment.
- Do not stop Denoci Injection without talking to your doctor. Stopping or delaying treatment may increase the risk of fractures, including multiple fractures of the spine. If treatment is stopped, your doctor may prescribe another medicine to prevent bone loss.
- Tell your doctor if you have kidney disease or are on dialysis. Advanced kidney disease significantly increases the risk of severe low calcium levels, and close monitoring may be required.
- Maintain good oral and dental hygiene and have regular dental checkups. Tell your dentist that you are receiving Denoci Injection before undergoing dental procedures.
- Contact your doctor if you develop new or unusual pain in your thigh, hip, or groin, as this may be an early sign of an unusual thigh-bone fracture.
- Seek medical attention if you develop symptoms of low calcium, such as muscle spasms or cramps, tingling or numbness around the mouth or in the fingers or toes.
- Do not use Denoci Injection during pregnancy. Women who can become pregnant should use effective contraception during treatment and for at least 5 months after the last dose.
Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney
However, patients with advanced kidney disease, especially those on dialysis, have an increased risk of severe low blood calcium levels (hypocalcemia). Close monitoring of calcium levels is recommended.

Liver

Interaction with drugs
Cinacalcet (Oral Route)
Frequently asked questions
Fact Box
Chemical Class
Habit Forming
Therapeutic Class
Action Class
Related lab tests
References
- Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
- Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
- Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
- Denosumab [Prescribing Information]. Thousand Oaks, CA: Amgen Inc.; 2026. [Accessed 22 Sept. 2026] (online) Available from:
- Denosumab [Prescribing Information]. Mumbai, India: Alkem Laboratories Ltd.; 2026. [Accessed 22 Sept. 2026] (online) Available from:
- Denosumab [EMC SmPC]. Milton Road, Cambridge: Amgen Ltd.; 2018. [Accessed 02 Apr. 2019] (online) Available from:




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Disclaimer
Marketer details
Address: Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Vendor Details
A licensed vendor partner from your nearest location will deliver Denoci Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)
















