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Denoci Injection 1
Denoci Injection 2
Denoci Injection 3
Denoci Injection 4

Denoci Injection

Denosumab (120mg)
Genuine
Authenticity Assured
Prescription
required
Cold stored
Stored between 2-8°C

Product Summary :

Denoci Injection is a monoclonal antibody containing denosumab used to treat osteoporosis in postmenopausal women and men at increased risk of fractures. It helps slow down bone breakdown, making bones stronger and reducing the risk of fractures. It is given as an injection under the skin once every 6 months. The doctor may advise calcium and vitamin D supplements during treatment. Common side effects include back pain, pain in the arms or legs, and muscle or bone pain. Do not stop or delay treatment without consulting your doctor, as this may increase the risk of fractures. Tell your doctor if you have kidney disease, especially if you are on dialysis, as Denoci Injection can cause severely low blood calcium levels.


Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 04 Oct 2026 | 01:01 AM (IST)
₹24244
MRP ₹32329.68
25% off
(Inclusive of applicable taxes)
1 Injection
Get by Tuesday, 6 October
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Gurgaon
 
 
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Product expires after May, 2027

Expiry date may vary by batch. All batches have a 3-month shelf life from the date of dispatch.

Price Info

MRP may vary by batch. Any additional charges, including packaging, handling, shipping or delivery charges, will be clearly disclosed before purchase.

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General Information

Contains

Denosumab (120mg)

Marketer

Cipla Ltd

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Denoci Injection 1
Denoci Injection 2
Denoci Injection 3
Denoci Injection 4

Product introduction

Denoci Injection is used to treat osteoporosis in postmenopausal women and men at increased risk of fractures. It is also used to manage bone loss associated with long-term glucocorticoid treatment. It works by slowing down bone breakdown, which helps increase bone strength and reduce the risk of fractures.

Denoci Injection is given by a healthcare professional and should not be self-administered. You should use it regularly and at the same time each day to get maximum benefit from it. Continue using it as recommended by your doctor and complete the dose even if you feel better. To make it more effective, take adequate amount of calcium and vitamin D supplements while on treatment with this medicine.

Some common side effects of this medicine include pain in extremity, musculoskeletal pain, nerve pain, urinary tract infection, constipation, and rash. Talk to your doctor if any of these side effects does not go away with time or get worse. Your doctor may help with ways to reduce or prevent these symptoms.

To make sure the medicine is safe for you, before taking it, let your doctor know of all the other medicines you are taking. It is important for pregnant and breastfeeding mothers to ask the advice of their doctors before using this medicine.

There is a Patient Support Program / Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details.

Uses of Denoci Injection

  • Treatment of Osteoporosis : Helps slow down bone breakdown, making bones stronger and reducing the risk of fractures in postmenopausal women and men at increased risk of fractures.

Benefits of Denoci Injection

Treatment of Osteoporosis
Osteoporosis is a condition in which the bones become weak and are more likely to break. Denoci Injection is used to treat osteoporosis in postmenopausal women and men at increased risk of fractures and can also help manage bone loss associated with long-term glucocorticoid treatment. It slows down bone breakdown and increases bone strength and density. This helps reduce the risk of fractures, including fractures of the spine, hip, and other bones.

Side effects of Denoci Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Denoci
  • Back pain
  • Pain in extremities
  • Hypercholesterolemia (high cholesterol)
  • Musculoskeletal (bone, muscle or joint) pain
  • Cystitis
  • Pancreatic inflammation
  • Joint pain
  • Nasopharyngitis (inflammation of the throat and nasal passages)
  • High blood pressure
  • Bronchitis (inflammation of the airways)
  • Headache

How to use Denoci Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Denoci Injection works

Denoci Injection is a monoclonal antibody that works by blocking a protein called RANKL, which is involved in the formation and activity of cells called osteoclasts that break down bone. Blocking RANKL reduces the formation and activity of these bone-breaking cells. This slows bone loss, increases bone mass, and helps make bones stronger.

Dosage

Denoci Injection is given as an injection under the skin once every 6 months, usually in the upper arm, thigh, or abdomen. The duration of treatment will depend on your condition and response to treatment. Your doctor will periodically assess whether you need to continue it. Adequate calcium and vitamin D should be taken during treatment as advised by your doctor. Do not stop or delay treatment without consulting your doctor.

All substitutes for Denoci Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • Take calcium and vitamin D supplements as advised by your doctor to help maintain normal calcium levels during treatment.
  • Do not stop Denoci Injection without talking to your doctor. Stopping or delaying treatment may increase the risk of fractures, including multiple fractures of the spine. If treatment is stopped, your doctor may prescribe another medicine to prevent bone loss.
  • Tell your doctor if you have kidney disease or are on dialysis. Advanced kidney disease significantly increases the risk of severe low calcium levels, and close monitoring may be required.
  • Maintain good oral and dental hygiene and have regular dental checkups. Tell your dentist that you are receiving Denoci Injection before undergoing dental procedures.
  • Contact your doctor if you develop new or unusual pain in your thigh, hip, or groin, as this may be an early sign of an unusual thigh-bone fracture.
  • Seek medical attention if you develop symptoms of low calcium, such as muscle spasms or cramps, tingling or numbness around the mouth or in the fingers or toes.
  • Do not use Denoci Injection during pregnancy. Women who can become pregnant should use effective contraception during treatment and for at least 5 months after the last dose.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Denoci Injection. Please consult your doctor.
Pregnancy

Pregnancy

UNSAFE
Denoci Injection is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CAUTION
Denoci Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

SAFE
Denoci Injection does not usually affect your ability to drive.
Kidney

Kidney

SAFE IF PRESCRIBED
Denoci Injection is safe to use in patients with kidney disease. No dose adjustment is recommended.
However, patients with advanced kidney disease, especially those on dialysis, have an increased risk of severe low blood calcium levels (hypocalcemia). Close monitoring of calcium levels is recommended.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Denoci Injection in patients with liver disease.
All

Interaction with drugs

Taking Denoci with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Moderate

Cinacalcet (Oral Route)

Your doctor may monitor your treatment and adjust the doses as per the observations. Denosumab may increase the metabolism of Cinacalcet.

Frequently asked questions

The duration of treatment with Denoci Injection depends on your condition and your risk of fractures. Your doctor will periodically assess whether you should continue treatment. Do not stop or delay treatment on your own, because stopping denosumab can increase the risk of fractures, including multiple fractures of the spine.
No. Denoci Injection is not a chemotherapy medicine. It is a monoclonal antibody that blocks RANKL, a protein involved in the formation and activity of cells that break down bone. This helps reduce bone loss and increase bone strength.
Denoci Injection is given as an injection under the skin by a doctor or a nurse. For osteoporosis and related bone-loss conditions, the recommended dose once every 6 months. Your doctor may also advise adequate calcium and vitamin D supplementation.
No. Denoci Injection should not be used during pregnancy because it may harm the unborn baby. Women who can become pregnant should use effective contraception during treatment and for at least 5 months after the last dose.
Yes, people with kidney disease can use Denoci Injection. However, people with advanced chronic kidney disease, especially those on dialysis, have a much greater risk of severe low calcium levels after receiving Denoci Injection. Your doctor may perform additional blood tests and monitor your calcium levels closely before and after treatment.
Stopping or delaying Denoci Injection can cause bone breakdown to increase again and may raise the risk of fractures. Multiple fractures of the spine can occur after discontinuing the medicine. If treatment needs to be stopped, your doctor may switch you to another medicine to reduce this risk.
Osteonecrosis of the jaw is an uncommon but serious problem reported with Denoci Injection. Maintain good oral hygiene and have regular dental checkups during treatment. Tell your doctor and dentist if you develop persistent jaw pain or swelling, loose teeth, or sores in the mouth that do not heal, and inform your dentist that you are receiving Denoci Injection before dental procedures.

Fact Box

Chemical Class

Peptides

Habit Forming

No

Therapeutic Class

PAIN ANALGESICS

Action Class

RANKL Inhibitor – Monoclonal Antibody

Related lab tests

References

  1. Bikle DD. Agents That Affects Bone Mineral Homoestasis. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 766.
  2. Friedman PA. Agents Affecting Mineral Ion Homeostasis and Bone Turnover. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 1299.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 370.
  4. Denosumab [Prescribing Information]. Thousand Oaks, CA: Amgen Inc.; 2026. [Accessed 22 Sept. 2026] (online) Available from:
  5. Denosumab [Prescribing Information]. Mumbai, India: Alkem Laboratories Ltd.; 2026. [Accessed 22 Sept. 2026] (online) Available from:
  6. Denosumab [EMC SmPC]. Milton Road, Cambridge: Amgen Ltd.; 2018. [Accessed 02 Apr. 2019] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Cipla Ltd
Address: Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Denoci Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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