Darzalex Injection

Daratumumab (100mg)

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required

Darzalex Injection is used in the treatment of multiple myeloma, which is a type of cancer of plasma cells.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 23 Mar 2026 | 11:29 AM (IST)

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General Information

Contains

Daratumumab (100mg)

Marketer

Janssen Pharmaceuticals

Storage

Store below 30°C

The content is shown in English

Product introduction

Darzalex Injection is given as an IV infusion into veins under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.

Infusion reaction such as swollen face, lips, mouth, tongue or throat, difficulty swallowing or breathing are very common side effects. This medicine may reduce the number of blood cells (decrease white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells while taking this medicine.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.

There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details.

Uses of Darzalex Injection

Treatment of Multiple myeloma

Benefits of Darzalex Injection

Treatment of Multiple myeloma
Multiple myeloma is a type of blood cancer that affects plasma cells in the bone marrow, leading to weak bones, anemia, kidney problems, and frequent infections. Darzalex Injection helps control the growth of these cancerous cells, improving symptoms, slowing disease progression, and enhancing quality of life.

Side effects of Darzalex Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Darzalex

Gastrointestinal toxicity
Headache
Decreased appetite
Joint inflammation
Chest pain
Decreased potassium level in blood
Weakness
Infection
Muscle spasm
Insomnia (difficulty in sleeping)
Peripheral edema
Infusion reaction
Altered blood cell count
Respiratory tract infection
Increased liver enzymes
Fatigue
Back pain

How to use Darzalex Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Darzalex Injection works

Darzalex Injection is a monoclonal antibodies, which are designed to recognise and attach to specific proteins on the surface of cancer cells. It shows its action by binding to specific cancer cells in the body and helps your immune system kills cancer.

Quick tips

Darzalex Injection is given in combination with other medicines for the treatment of multiple myeloma.
Drink at least two to three quarts of fluid every 24 hours while on treatment with Darzalex Injection, unless you are instructed otherwise.
To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
Avoid sun exposure. Wear SPF 30 (or higher) sunblock and protective clothing.
Do not receive any kind of immunization or vaccination without your doctor's approval while taking Darzalex Injection.
Use contraceptives, and avoid getting pregnant while taking Darzalex Injection. Barrier methods of contraception, such as condoms, should be used during treatment and for 3 months after the last dose of Darzalex Injection.
Before receiving Darzalex Injection inform your doctor if you have a history of breathing problems or hepatitis B infection.
Let your doctor know if you are pregnant or plan to become pregnant or breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Darzalex Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Darzalex Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Darzalex Injection during breastfeeding is not available. Please consult your doctor.

Driving

CAUTION

Darzalex Injection may cause dizziness or weakness due to changes in blood pressure. Do not drive if these symptoms occur.

Kidney

SAFE IF PRESCRIBED

Darzalex Injection is safe to use in patients with kidney disease. No dose adjustment is recommended.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Darzalex Injection in patients with liver disease.

Frequently asked questions

What is Darzalex Injection used for?

Darzalex Injection is prescribed for adults with multiple myeloma (a type of cancer of plasma cells) and may be given alone or with other medicines, depending on the treatment plan and prior therapies.

What are the most important infusion-related warnings of Darzalex Injection?

Can Darzalex Injection affect blood transfusions or blood tests?

Yes, Darzalex Injection can cause a positive indirect Coombs test and interfere with matching blood for transfusions for up to six months after the last dose, so a blood type and screen is done before starting this medicine, and blood banks must be informed about current or recent treatment.

Does Darzalex Injection lower blood counts?

Darzalex Injection can reduce white blood cells (raising infection risk) and platelets (raising bleeding risk), so regular blood tests are done, and dosing may be delayed until counts recover when needed.

Can hepatitis B reactivate with Darzalex Injection?

Yes, hepatitis B can reactivate with Darzalex Injection, rarely causing severe illness. Doctors check hepatitis B status before, during, and after treatment and monitor for symptoms such as worsening tiredness or yellowing of eyes/skin.

Does Darzalex Injection change how doctors measure myeloma response?

Yes, Darzalex Injection can appear on serum protein tests (SPEP/IFE) and look like the myeloma protein, potentially masking a complete response. Specialized assays may be used to distinguish the medicine from the disease protein when needed.

Are there special cautions for breathing or eye symptoms during receiving Darzalex Injection?

People with chronic lung disease may need extra inhaled medicines in addition to receiving Darzalex Injection. Additionally, any new eye pain, blurred vision, or acute vision changes during receiving Darzalex Injection should trigger an immediate pause and urgent eye evaluation before restarting.

What should be done before starting Darzalex Injection treatment to improve safety?

Before starting Darzalex Injection, your doctor will check your blood type and hepatitis B status, plan medicines to prevent infusion reactions, and arrange regular blood count monitoring. You should also inform your doctor about any past infections, lung problems, and all medicines or supplements you’re taking.

Fact Box

Chemical Class

Peptides

Habit Forming

Therapeutic Class

ANTI NEOPLASTICS

Related lab tests

Albumin/Globulin Ratio, Serum

Calcium

Complete Blood Count

Kidney Function Test

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Janssen Pharmaceuticals
Address: Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060

Vendor Details

Country of origin: United kingdom

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Why we need a prescription?

Darzalex Injection

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Darzalex Injection

Benefits of Darzalex Injection

Side effects of Darzalex Injection

How to use Darzalex Injection

How Darzalex Injection works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Darzalex Injection used for?

What are the most important infusion-related warnings of Darzalex Injection?

Can Darzalex Injection affect blood transfusions or blood tests?

Does Darzalex Injection lower blood counts?

Can hepatitis B reactivate with Darzalex Injection?

Does Darzalex Injection change how doctors measure myeloma response?

Are there special cautions for breathing or eye symptoms during receiving Darzalex Injection?

What should be done before starting Darzalex Injection treatment to improve safety?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Related lab tests

Albumin/Globulin Ratio, Serum

Calcium

Complete Blood Count

Kidney Function Test

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests