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Daramin 25mg Tablet

Pyrimethamine (25mg)
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Daramin 25mg Tablet is an antiparasitic medicine, used for the treatment of malaria. It works by killing the malaria causing parasite and stops the infection from spreading.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 27 Jul 2026 | 01:05 AM (IST)
₹14 MRP ₹15.238% off 
 
 
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General Information

The content is shown in English
Daramin 25mg Tablet image
Daramin 25mg Tablet image

Product introduction

Daramin 25mg Tablet should be used in the dose and duration as advised by your doctor. Take it with food to decrease the risk of stomach upset. Do not skip any doses and finish the full course of treatment even if you feel better. If it is given with sulfonamides, it should be given with folic acid (vitamin) supplements.

Some people may experience nausea, headache, stomach pain, and muscle pain, as side effects of this medicine. Please consult your doctor if these side effects persist for a longer duration. Inform your doctor if you ever had fits (seizures) or any problems with your kidney, heart or liver.

Uses of Daramin Tablet

Benefits of Daramin Tablet

Malaria
Daramin 25mg Tablet is an antimalarial medicine and is used to treat malaria, a serious or life-threatening illness that is spread by a parasite that enters the human body by the bite of infected mosquitoes. It kills the infection causing parasite and stops further spread of the infection. Take it only as prescribed and refrain from taking any other medicines along with this medicine (unless advised by the doctor) as they may affect the absorption of this medicine. Do not use this medicine for treating any other condition without consulting your doctor.

Side effects of Daramin Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Daramin
  • Nausea
  • Headache
  • Abdominal pain
  • Muscle pain
  • Abnormal bruising
  • Abnormal skin pigmentation
  • Anemia (low number of red blood cells)
  • Change in blood test results
  • Diarrhea
  • Dizziness
  • Vomiting
  • Weakness

How to use Daramin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Daramin 25mg Tablet should be taken with or after food.

How Daramin Tablet works

Daramin 25mg Tablet is an antiparasitic medication which treats malaria. It works by increasing the levels of haeme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading.

Quick tips

  • Daramin 25mg Tablet should be taken with food to prevent a stomach upset. 
  • Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
  • Tips to reduce the chance of being bitten by mosquitoes:
    • Wear light-colored and covered clothing when you are outside after sunset.
    • Use insect repellent creams or sprays on parts of your body not covered by clothing.
    • Spray to kill any mosquitoes that may have entered rooms in spite of screening.
  • Inform your doctor if you have kidney liver or heart disease.
  • Daramin 25mg Tablet should be taken on an empty stomach.
  • Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
  • Tips to reduce the chance of being bitten by mosquitoes:
    • Wear light-colored and covered clothing when you are outside after sunset.
    • Use insect repellent creams or sprays on parts of your body not covered by clothing.
    • Spray to kill any mosquitoes that may have entered rooms in spite of screening.
  • If you vomit within 1 hour of taking the tablets, take another dose. 
  • Inform your doctor if you have kidney liver or heart disease.

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Daramin 25mg Tablet.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Daramin 25mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Daramin 25mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Daramin 25mg Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Daramin 25mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Daramin 25mg Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
All

Interaction with drugs

Taking Daramin with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Severe

Co-trimoxazole (Oral Route)

Caution is advised when taking Pyrimethamine with Co-trimoxazole. If concurrent use is essential, your doctor may monitor the effects of the medicines and adjust the doses as per the observations.
Severe

Sulfadiazine (Oral Route)

Caution is advised when taking Pyrimethamine with Sulfadiazine. If concurrent use is essential, your doctor may monitor the effects of the medicines and adjust the doses as per the observations.
Severe

Trimethoprim (Oral Route)

Caution is advised when taking Pyrimethamine with Trimethoprim. If concurrent use is essential, your doctor may monitor the effects of the medicines and adjust the doses as per the observations.
Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Pyrimethamine may reduce the efficacy of Purified Vi Polysaccharide Typhoid Vaccine. Pyrimethamine may reduce the efficacy of Purified Vi Polysaccharide Typhoid Vaccine.
Severe

Cholera Vaccine (Inactivated) (Oral Route)

Do not consume Cholera Vaccine (Inactivated) two weeks before and at least 10 days after consuming Pyrimethamine. Please consult your doctor. Pyrimethamine may reduce the efficacy of Cholera Vaccine (Inactivated).

Frequently asked questions

Daramin 25mg Tablet is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.
Use of Daramin 25mg Tablet should be avoided in patients who are allergic to Daramin 25mg Tablet or any of its components. However, if you are not aware of any allergy or if you are using Daramin 25mg Tablet for the first time, consult your doctor.
Before starting treatment with Daramin 25mg Tablet, inform your doctor if you have any other health conditions like kidney or heart-related problems. This is because certain medical conditions may affect your treatment and you may even need dose modifications. Also, let your doctor know about all the other medicines you are taking because they may affect, or be affected by, this medicine. Inform your doctor if you are pregnant or breastfeeding.
If you forget a dose of Daramin 25mg Tablet, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose in the prescribed time. Do not double the dose to make up for the missed one as this may increase the chances of developing side effects.
No, do not stop taking Daramin 25mg Tablet without consulting your doctor even if you are feeling better. Your symptoms may improve before the infection is completely cured. Therefore, for better and complete treatment, it is advised to continue your treatment for the prescribed duration.
Symptoms of malaria can develop as quickly as 7 days after you are being bitten by an infected mosquito. Typically, the time between being infected and the appearance of symptoms (incubation period) is 7 to 18 days. However, in some cases it can take up to one year for the symptoms to develop. Initial symptoms of malaria are flu-like which include feeling hot and shivery, muscle pains, vomiting, headaches and diarrhea.
Malaria can be avoided by taking the right approach towards prevention. Avoid mosquito bites by covering your arms and legs, using mosquito net and insect repellent. Check with your doctor whether you need to take malaria prevention tablets. If you do, make sure you take the right antimalarial tablets at the right dose, and finish the proper course of treatment. Seek immediate medical advice from the doctor if you have malaria symptoms.

Fact Box

Chemical Class

Aminopyrimidine derivative

Habit Forming

No

Therapeutic Class

ANTI MALARIALS

Action Class

Other Antimalarial Agents

References

  1. Vinetz JM, Clain J, Bounkeua V, et al. Chemotherapy of Malaria. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1399-400.
  2. Rosenthal PJ. Antiprotozoal Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 908-910.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 1179-80.
  4. Pyrimethamine. Research Triangle Park, North Carolina: DSM Pharmaceuticals; 2003. [Accessed 30 Mar. 2019] (online) Available from:
  5. Chaves RG, Lamounier JA. Breastfeeding and maternal medications. Jornal de Pediatria. 2004; 80(5):4-6. [Accessed 29 Mar. 2019] (online) Available from:
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User feedback

Others
71%
Malaria
29%
Poor
100%
Dizziness
100%
With food
100%
Not Expensive
100%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Indica Laboratories Pvt Ltd
Address: L.B. SHASHTRI ROAD, AHMEDABAD - 3800025

Vendor Details

Country of origin: India
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