COXTER 450 MG/300 MG TABLET

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Rs.52.43for 1 strip(s) (10 tablets each)
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Composition FOR COXTER

Rifampicin(450mg),Isoniazid(300mg)

food interaction for COXTER

alcohol interaction for COXTER

pregnancy interaction for COXTER

lactation interaction for COXTER

food
alcohol
pregnancy
lactation
Avoid Coxter 450 mg/300 mg tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
UNSAFE
Coxter 450 mg/300 mg tablet may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
UNSAFE
Coxter 450 mg/300 mg tablet may be unsafe to use during pregnancy.
Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
WEIGH RISKS VS. BENEFITS
Coxter 450 mg/300 mg tablet is probably safe to use during breastfeeding. Please consult your doctor.
SAFE

SALT INFORMATION FOR COXTER

Rifampicin(450mg)

Uses

Rifampicin is used in the treatment of tuberculosis (tb) and leprosy.

How it works

Rifampicin is an antibiotic. It works by killing the bacteria that cause infections.

Common side effects

Skin rash, Nausea, Vomiting, Chills, Muscle pain.
Isoniazid(300mg)

Uses

Isoniazid is used in the treatment of tuberculosis (tb).

How it works

Isoniazid is an antibiotic. It works by killing the bacteria that causes tuberculosis.

Common side effects

Peripheral neuropathy (tingling and numbness of feet and hand), Increased liver enzymes, Hepatitis (viral infection of liver), Jaundice.

SUBSTITUTES FOR COXTER

38 Substitutes
38 Substitutes
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  • MACOX PLUS TABLET
    (6 tablets in strip)
    Macleods Pharmaceuticals Pvt Ltd
    Rs. 7.42/tablet
    Tablet
    Rs. 44.50
    pay 41% more per tablet
  • AKT-2 TABLET
    (10 tablets in strip)
    Lupin Ltd
    Rs. 6.75/tablet
    Tablet
    Rs. 67.50
    pay 29% more per tablet
  • MYCOCOX 450 MG/300 MG TABLET
    (10 tablets in strip)
    Cadila Pharmaceuticals Ltd
    Rs. 5.68/tablet
    Tablet
    Rs. 56.80
    pay 8% more per tablet
  • RF COMPOUND 450 MG/300 MG TABLET
    (10 tablets in strip)
    Sunij Pharma Pvt Ltd
    Rs. 5.69/tablet
    Tablet
    Rs. 56.87
    pay 8% more per tablet
  • VICOX 2 TABLET
    (10 tablets in strip)
    Shrinivas Gujarat Laboratories Pvt Ltd
    Rs. 7.90/tablet
    Tablet
    Rs. 79
    pay 51% more per tablet

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Expert advice FOR COXTER

  • Rifampin interacts with many drugs. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects.
  • Do consult your doctor before taking rifampin if you wear contact lenses. Using rifampin may permanently stain your contact lenses.
  • Taking rifampin may produce a brownish-red coloration of the urine, sweat, sputum and tears. This is not a harmful effect.
  • Do consult your doctor before taking rifampin if you are pregnant or planning to become pregnant.
  • Do consult your doctor if you are taking oral contraceptive medications for birth control. Your doctor may ask you to use other means of birth control (eg. condom, diaphragm with spermicide) to prevent pregnancy while taking rifampin.
  • Do consult your doctor before taking rifampin if you are breast-feeding.
  • Do consult your doctor before taking rifampin if you are aged 65 years or above.
  • If you take rifampin irregularly or if daily administration is resumed after a drug free interval, you may experience ‘flu syndrome’ (includes episodes of fever, chills, headache, dizziness, and bone pain).
  • Rifampin should preferably be taken in the morning before breakfast. Taking rifampin with food is known to delay its absorption (process by which the active drug reaches the affected site in the body via blood circulation) thereby, hampering its effectiveness.
  • Do not stop taking rifampin without consulting your doctor.

Frequently asked questions FOR COXTER

Rifampicin

Q. Is rifampin and rifampicin same?
Yes. Rifampin (nomenclature in the United States) and rifampicin (nomenclature in Britain) is the same antibiotic commonly used in the treatment of tuberculosis and leprosy
Q. Is rifampin a penicillin/amoxicillin/sulfa drug?
No. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has a structure and mechanism of action different from penicillin or amoxicillin (amoxicillin belongs to the class of penicillin antibiotics). The chemical structure and mechanism of action of rifampin is different from sulfa drugs
Q. Is rifampin bacteriostatic or bactericidal?
Rifampin is a bactericidal drug. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase which essential for important life processes in the bacteria, thereby killing the bacteria
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Q. Is rifampin an inducer or inhibitor?
Rifampin is an inducer (increases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body
Q. What is R-cin 600 used for?
R-cin 600 is a trade name for active drug rifampin 600 mg. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It is also used in the prevention of meningococcal meningitis and Haemophilus influenza infections. It may also be used in combination with other drugs to treat infections-Brucellosis, Legionnaires disease or serious staphylococcal infections
Q. What is R-cinex/Macox plus/R-cinex 600?
R-cinex and Macox plus are trade names for a combination of active drugs rifampin and isoniazid. It is used in the treatment of tuberculosis. R-cinex 600 and Macox plus contains 600 mg of active drug rifampin and 300 mg of active drug isoniazid
Q. Can I take rifampin with ibuprofen/acetaminophen (Tylenol)?
Rifampin has no known serious drug interaction with ibuprofen or acetaminophen (trade name: Tylenol). Inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does rifampin cause weight gain/weight loss/ hair loss/ constipation/ yeast infection?
No. Changes in body weight, hair loss or triggering constipation are not among the known side effects of rifampin. Rifampin is an antibiotic commonly used in the treatment of tuberculosis and leprosy. It has no known effect on causing yeast infections
Q. Does rifampin cause headaches?
Yes. Headache is a possible side effect of rifampin
Q. Does rifampin change urine color/turn urine orange?
Yes. Taking rifampin may change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful
Q. Does rifampin cause liver damage?
Rifampin is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with rifampin. Taking drugs like saquinavir, ritonavir with rifampin can cause severe liver damage. Do consult your doctor if you have any liver problem before taking rifampin.

Isoniazid

Q. Is isoniazid an antibiotic?
Isoniazid is an antibiotic used in the prevention and treatment of tuberculosis or TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body)
Q. Is isoniazid chemotherapy/chemotherapy drug?
Isoniazid is a primary antibiotic used for treatment of tuberculosis. Do not confuse it with chemotherapy or chemo drugs used for the treatment of cancer
Q. Is isoniazid bacteriostatic or bactericidal?
Isoniazid is a bacteriostatic antibiotic. It stops or suppresses growth of tuberculosis causing bacteria by interfering with the formation of protective outer covering (cell wall) which is essential for their growth
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Q. Is isoniazid safe?
Yes. Isoniazid is safe if used at prescribed doses for the prescribed duration as advised by your doctor
Q. Is isoniazid a MAOI?
Isoniazid has very weak inhibitory activity on enzymes monoamine oxidases (MAO); however it is not used as a monoamine oxidase inhibitor (MAOI)
Q. Is isoniazid a sulfa drug?
No. The chemical structure and mechanism of action of isoniazid is different from sulfa drugs
Q. Is isoniazid an inducer or inhibitor?
Isoniazid is an inhibitor (decreases activity) of an important liver enzyme system that is responsible for the final processing and elimination of several drugs from the body
Q. Can I take isoniazid with ibuprofen/Benadryl/Nyquil/Aleve/Mucinex/amoxicillin?
There no known serious drug interactions of isoniazid with ibuprofen, paracetamol (trade name: Tylenol), naproxen (trade name: Aleve), amoxicillin or any active drug present in Nyquil or Mucinex. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does isoniazid cause weight loss/weight gain/hair loss/diarrhea/affect menstruation?
Changes in body weight (gain/loss), hair loss, diarrhea or changes in menstruation are not among the known side effects of isoniazid. You may experience few of these side effects while on multi drug (including isoniazid) treatment for tuberculosis
Q. Does isoniazid cause acne/make you tired/cause constipation?
You may experience unusual tiredness, constipation or acne while on treatment with isoniazid. Please inform your doctor about all the medication you are currently taking to avoid interactions that may reduce effectiveness of any treatment or aggravate side effects
Q. Does isoniazid affect birth control?
Isoniazid has no known interaction with commonly used oral contraceptives (birth control pills). However, multidrug treatment for tuberculosis contains active drug rifampin that decreases the effectiveness of oral contraceptives and hampers birth control.

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Content on this page was last updated on 08 March, 2017, by Dr. Varun Gupta (MD Pharmacology)