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MRP: Rs. 90.58 for 1 vial(s) (1 ML injection each)
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Composition for COSMEGEN

Dactinomycin(500 mcg)

food interaction for COSMEGEN

alcohol interaction for COSMEGEN

pregnancy interaction for COSMEGEN

lactation interaction for COSMEGEN

It can be taken with or without food, but it is better to take Cosmegen 500mcg injection at a fixed time.
Interaction with alcohol is unknown. Please consult your doctor.
Cosmegen 500mcg injection is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Cosmegen 500mcg injection is probably unsafe to use during breastfeeding. Please consult your doctor.


Dactinomycin(500 mcg)


  • Cosmegen 500mcg injection is used as a part of a combination treatment for Wilms’ tumor (type of cancer of the kidneys) in children, childhood rhabdomyosarcoma (cancers affecting muscles), Ewing's sarcoma (cancers affecting muscles and bones), and metastatic nonseminomatous testicular cancers.
  • It is used either alone or as a part of combination regimen in the treatment of gestational trophoblastic neoplasia (cancers of the pregnant uterus).
  • It is also indicated in cancers of the skin, breast, endometrium, ovary, thyroid, stomach, bladder, liver, and lung, soft tissue sarcomas and in hematologic malignancies (cancers of the blood) such as acute lymphoblastic leukemia, multiple myeloma, and Hodgkin’s and non-Hodgkin’s lymphomas.

How it works

Cosmegen 500mcg injection belongs to a class of medicines known as anthracyclines. It is a cytotoxic, antineoplastic (anticancer) medicine that works by binding to DNA (gene) and stopping the RNA synthesis, thereby slowing or stopping the growth of cancer cells in the body.

Common side effects

Nausea, Pharyngitis, Pneumonitis, Anorectal inflammation, Liver disorder, Abdominal pain, Acne, Myelosuppression, Anemia, Lip swelling, Diarrhoea, Difficulty in swallowing, Erythema multiforme, Esophagitis, Gastrointestinal ulcer, Hair loss, Decreased calcium level in blood, Infection, Loss of appetite, Muscle pain, Sepsis, Skin eruptions, Ulcerative stomatitis, Vomiting


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Expert advice for COSMEGEN

  • Use appropriate contraception during treatment with dactinomycin, if you are women of childbearing potential.
  • During administration, avoid inhalation of dust or vapors and contact with eyes or mucous membranes as it is highly toxic and extremely corrosive to soft tissues.
  • Take precautions while taking dactinomycin as you may develop life threatening allergic reactions.
  • You may be monitored daily for any side effects during treatment as it may cause toxic reactions such as stomatitis, diarrhea, severe hematopoietic depression.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions for COSMEGEN


Q. Is dactinomycin an anthracycline?
Yes, dactinomycin is an anthracycline.
Q. Is dactinomycin a vesicant (agent that causes tissue blistering and damage)?
Yes, dactinomycin is a vesicant; it may cause tissue blistering if it leaks out of the vein.


Content on this page was last updated on 06 May, 2014, by Dr. Varun Gupta (MD Pharmacology)