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Dactinomycin

Information

Uses

Dactinomycin is used in the treatment of testicular cancer, wilms' tumor (kidney cancer in young children), gestational trophoblastic neoplasia (abnormal growth of cells inside a woman's uterus) and ewing's sarcoma

How it works

Dactinomycin works by damaging the genetic material (DNA) of the cancer cells and stops their growth and multiplication.

Common side effects

Reduced blood platelets, Joint pain, Headache, Nail pigmentation, Back pain, Interstitial pneumonia, Anorectal inflammation, Myelosuppression, Sepsis, Pulmonary fibrosis, Gastrointestinal ulcer, Nail discoloration, Muscle pain, Haemorrhage, Vomiting, Ulcerative stomatitis, Weakness, Erythema multiforme, Pneumonitis, Lip swelling, Nausea, Liver disorder, Abdominal pain, Musculoskeletal pain, Infection, Pharyngitis, Difficulty in swallowing, Glossitis, Loss of appetite, Lip inflammation, Decreased white blood cell count, Decreased calcium level in blood, Hair loss, Absence of menstrual periods, Fatigue, Acne, Fever, Anemia, Chills, Diarrhoea, Blood in urine, Rigors, Hypersensitivity, Skin eruptions, Feeling of discomfort, Cough, Weight loss, Esophagitis, Altered taste, Febrile neutropenia, Peripheral sensory neuropathy, Decreased white blood cell count (neutrophils), Hand-foot syndrome, Constipation, Neuropathy, Stomatitis, Nail disorder, Infusion reaction, Oral ulcer, Breathing difficulty

Available Medicine

  • ₹445
    Celon Laboratories Ltd
    1 variant(s)
  • ₹412
    Neon Laboratories Ltd
    1 variant(s)
  • ₹90
    Wockhardt Ltd
    1 variant(s)

Expert advice

  • Use appropriate contraception during treatment with dactinomycin, if you are women of childbearing potential.
  • During administration, avoid inhalation of dust or vapors and contact with eyes or mucous membranes as it is highly toxic and extremely corrosive to soft tissues.
  • Take precautions while taking dactinomycin as you may develop life threatening allergic reactions.
  • You may be monitored daily for any side effects during treatment as it may cause toxic reactions such as stomatitis, diarrhea, severe hematopoietic depression.
  • Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Frequently asked questions

Dactinomycin

Q.

Is dactinomycin an anthracycline?
Yes, dactinomycin is an anthracycline

Q.

Is dactinomycin a vesicant (agent that causes tissue blistering and damage)?
Yes, dactinomycin is a vesicant; it may cause tissue blistering if it leaks out of the vein.


Content on this page was last updated on 15 February, 2017, by Dr. Varun Gupta (MD Pharmacology)