Combunex 800 Tablet

Isoniazid (300mg)+ Ethambutol (800mg)

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required

Combunex 800 Tablet is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection.

Written By Dr. Lipika Khurana, PGDHHM, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 02 Mar 2026 | 12:39 PM (IST)

₹115 MRP ₹1279% off

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General Information

Contains

Isoniazid (300mg)+ Ethambutol (800mg)

Marketer

Lupin Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Combunex 800 Tablet is a prescription medicine and it is to be taken it as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve.

Some common side effects of this medicine are nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, etc. To cope up with the side effects, you should drink plenty of water. If any of the side effects get aggravated, you must consult your doctor immediately. Generally, serious side effects are rare. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.

Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Patients with liver and kidney ailments must take this medicine with proper consultation and caution. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. During the treatment, you must take adequate rest and eat a healthy diet for a faster recovery. While on the medication, your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.

Uses of Combunex Tablet

Treatment of Tuberculosis (TB)

Benefits of Combunex Tablet

Treatment of Tuberculosis (TB)
Tuberculosis is an infectious disease that mainly affects the lungs but can affect other parts of the body as well. Combunex 800 Tablet helps treat tuberculosis by stopping the growth of bacteria causing infection. Your symptoms might improve after using Combunex 800 Tablet. However, make sure to complete the full course of treatment. This will ensure that the infection is completely cured and prevent it from returning.

Side effects of Combunex Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Combunex

Peripheral neuropathy (tingling and numbness of feet and hand)
Increased liver enzymes
Jaundice
Increased uric acid level in blood
Gout
Visual impairment

How to use Combunex Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Combunex 800 Tablet is to be taken on an empty stomach.
Avoid Combunex 800 Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How Combunex Tablet works

Combunex 800 Tablet is a combination of two medicines: isoniazid and ethambutol which treat tuberculosis. Isoniazid prevents the TB bacteria from forming their own protective covering. This kills the bacteria and eradicate the infection. Ethambutol, on the other hand works by slowing the growth of these bacteria.

Quick tips

Combunex 800 Tablet should be taken on an empty stomach but at the same time every day.
Do not skip any doses and finish the full course of treatment even if you feel better.
It may cause dizziness. Don't drive or do anything that requires mental focus until you know how Combunex 800 Tablet affects you.
It is advisable to stay hydrated and drink plenty of water to overcome medicine side effects.
Avoid consuming alcohol while taking this medication as it can enhance the dizziness.
Your doctor may monitor your liver function, vision and thyroid function while on treatment with this medicine.

Safety advice

Alcohol

UNSAFE

Consumption of alcohol with Combunex 800 Tablet may cause a disulfiram-like reaction, leading to symptoms such as flushing, increased heart rate, low blood pressure, nausea, lightheadedness, and severe headache.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Combunex 800 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Available human data suggest that the drug does not pass into breast milk in clinically significant amounts and is unlikely to harm the infant.

Driving

UNSAFE

Combunex 800 Tablet may cause side effects that could affect your ability to drive.
Combunex 800 Tablet occasionally causes sight problems and tingling or numbness in hand or feet. After taking this medicine you should not drive until you know how it affects you.

Kidney

CAUTION

Combunex 800 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Kidney function tests are advisable before the start of this medicine.

Liver

CAUTION

Combunex 800 Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

What is Combunex 800 Tablet used for?

Combunex 800 Tablet is used in the continuation phase of tuberculosis (TB) treatment. It helps stop the TB bacteria from multiplying and lowers the risk of drug resistance.

Does Combunex 800 Tablet cure tuberculosis permanently?

Combunex 800 Tablet is a part of a complete TB treatment plan, but is not used alone. When taken correctly with other TB medicines, they help cure tuberculosis and prevent relapse.

Who should not take Combunex 800 Tablet?

Individuals should not take Combunex 800 Tablet if they have severe liver disease, optic neuritis (serious eye nerve problems), previous severe reactions to isoniazid or ethambutol, or any other ingredient present in this medicine.

Can children take Combunex 800 Tablet safely?

Combunex 800 Tablet is not recommended for children under 13 years without careful monitoring. Also, since children may not report eye problems early, it is difficult to prevent eye damage in children. Separate doses are preferred in younger children.

What are the serious side effects of Combunex 800 Tablet?

Serious side effects of Combunex 800 Tablet include hepatitis (liver damage), vision problems like blurred vision or color blindness, severe allergic reactions, nerve problems (tingling or numbness), and rare blood disorders. If you experience any of these symptoms, seek immediate medical attention.

Why are regular eye checks important while taking Combunex 800 Tablet?

Combunex 800 Tablet may cause optic neuritis, leading to vision problems such as color blindness or reduced eyesight. Regular eye tests are important to detect early changes and prevent permanent damage.

Can Combunex 800 Tablet damage the liver?

Yes, Combunex 800 Tablet can cause severe liver damage, especially in people over 35, alcohol users, and those with existing liver disease. Monthly monitoring and liver function tests are strongly advised.

Fact Box

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Related lab tests

Complete Blood Count

Erythrocyte Sedimentation Rate

Mycobacterium Tuberculosis DNA PCR - Qualitative

Peripheral Smear Examination

References

User feedback

Patients taking Combunex 800 Tablet

Once A Day

97%

Twice A Day

Alternate Day

What are you using Combunex Tablet for?

Tuberculosis (TB)

72%

Others

28%

How much was the improvement?

Excellent

57%

Average

27%

Poor

17%

What were the side-effects while using Combunex 800 Tablet?

No Side Effect

62%

Increased liver enzymes

12%

Increased uric acid level in blood

12%

Peripheral neuropathy (tingling and numbness of feet and hand)

12%

How do you take Combunex Tablet?

With food

67%

Empty stomach

17%

With or without food

17%

Please rate Combunex 800 Tablet on price

Average

72%

Expensive

28%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Lupin Ltd
Address: 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Combunex 800 Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Combunex Tablet

Benefits of Combunex Tablet

Side effects of Combunex Tablet

How to use Combunex Tablet

How Combunex Tablet works

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Combunex 800 Tablet used for?

Does Combunex 800 Tablet cure tuberculosis permanently?

Who should not take Combunex 800 Tablet?

Can children take Combunex 800 Tablet safely?

What are the serious side effects of Combunex 800 Tablet?

Why are regular eye checks important while taking Combunex 800 Tablet?

Can Combunex 800 Tablet damage the liver?

Fact Box

Habit Forming

Therapeutic Class

Related lab tests

Complete Blood Count

Erythrocyte Sedimentation Rate

Mycobacterium Tuberculosis DNA PCR - Qualitative

Peripheral Smear Examination

References

User feedback

Patients taking Combunex 800 Tablet

What are you using Combunex Tablet for?

How much was the improvement?

What were the side-effects while using Combunex 800 Tablet?

How do you take Combunex Tablet?

Please rate Combunex 800 Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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