Combose 0.5 Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 07 Jan 2026 | 03:29 PM (IST)

Combose 0.5 Tablet is a combination of two medicines used to treat type 2 diabetes mellitus. It helps control the high blood sugar levels in your body after each meal. It is used when other similar medicines along with a restricted diet, are unable to control abnormally high blood sugar levels.

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₹98.4 MRP ₹111.5612% off

Combose 0.5 Tablet is currently sold out

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Volibo R 0.5mg/0.3mg Tablet

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Combose 0.5 Tablet

strip of 10 tablets

₹98.4

~~₹111.56~~

Same composition

Volibo R 0.5mg/0.3mg Tablet

strip of 10 tablets

Repaglinide (0.5mg) + Voglibose (0.3mg)

by Sun Pharmaceutical Industries Ltd

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General Information

Contains

Repaglinide (0.5mg)+ Voglibose (0.3mg)

Marketer

ADN Life Sciences

Storage

Store below 25°C

The content is shown in English

Product introduction

Combose 0.5 Tablet should be taken just after meals. The dose will be decided by your doctor. Do not stop taking it without asking your doctor. If you do, your blood sugar levels may increase and put you at risk of serious complications like kidney damage and blindness. If you miss a dose, do not take the missed dose between two meals. Wait until your next meal and take it just after meals as usual. Do not take a double dose to make up for the missed dose. This medicine is only part of a treatment program that should include a healthy diet, regular exercise, and weight reduction as advised by your doctor.

The most common side effects of this medicine include flatulence, diarrhea, stomach pain, hypoglycemia (low blood sugar level), and skin rash. However, these are temporary and usually resolve on their own. Please consult your doctor if these do not resolve or persist for a longer duration. Monitor your blood sugar levels regularly while taking this medicine.

Before taking this medicine, inform your doctor if you have any kidney or liver problems or urinary tract infection or if you are on water pills (diuretics). Pregnant or breastfeeding women should also consult their doctor before taking it. Avoid excessive alcohol intake while taking it as this may increase the risk of developing some side effects.

Uses of Combose Tablet

Treatment of Type 2 diabetes mellitus

Benefits of Combose Tablet

Treatment of Type 2 diabetes mellitus
Combose 0.5 Tablet is a medicine that helps to control high blood glucose (sugar) levels. It helps get rid of extra glucose from your body through urine. It helps to slow down the breaking down of food in our intestine to simple glucose (sugar), thereby decreasing the rise in blood glucose levels after meals. Lowering blood glucose levels is an essential part of managing diabetes. If you can control the level, you will reduce the risk of getting any of the serious complications of diabetes such as kidney damage, eye damage, nerve problems and loss of limbs.
Combose 0.5 Tablet will reduce the risk of dying from cardiovascular disease if you have type 2 diabetes and already have cardiovascular disease. Taking this medicine regularly along with proper diet and exercise will help you live a normal, healthy life. You should keep using it for as long as it is prescribed because it is protecting your future health.

Side effects of Combose Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Combose

Headache
Hypoglycemia (low blood glucose level)
Abdominal pain
Diarrhea
Flatulence

How to use Combose Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Combose 0.5 Tablet is to be taken on an empty stomach.

How Combose Tablet works

Repaglinide and voglibose help control blood sugar levels in people with type 2 diabetes. Repaglinide increases the release of insulin after meals, helping the body manage rises in blood sugar. Voglibose slows down the digestion and absorption of carbohydrates from food, which helps prevent sudden spikes in blood sugar after eating. Together, they support better post-meal blood sugar control.

All substitutes for Combose 0.5 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Combose 0.5 Tablet is a combination medicine that can control blood sugar better than either medicine alone.
Exercise, eat a healthy diet, and take your other diabetes medicines along with Combose 0.5 Tablet.
Take it around 15 minutes before a main meal.
It can cause hypoglycemia (low blood sugar level) with other antidiabetic medicines, alcohol or if you delay a meal. Check your blood sugar regularly.
Always carry some sugary food to manage hypoglycemia symptoms (cold sweats, pale skin, tremors, and anxiety).

Safety advice

Alcohol

CAUTION

Alcohol should be used with caution while taking Combose 0.5 Tablet.

Pregnancy

UNSAFE

Combose 0.5 Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.

Breast feeding

UNSAFE

Combose 0.5 Tablet is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

Driving

CAUTION

Combose 0.5 Tablet may affect your driving ability if your blood sugar becomes too low or too high. Monitor your blood glucose and avoid driving if affected.

Kidney

CAUTION

Combose 0.5 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Combose 0.5 Tablet should be used with caution in patients with severe liver disease. Dose adjustment may be needed.

Frequently asked questions

What is Combose 0.5 Tablet used for?

Combose 0.5 Tablet is prescribed for people with type 2 diabetes to help control high blood sugar levels. It works best along with diet and exercise to keep blood sugar within a healthy range.

Can Combose 0.5 Tablet cure diabetes?

No. Combose 0.5 Tablet does not cure diabetes. It helps manage type 2 diabetes by keeping blood sugar levels under control, which reduces the risk of complications like kidney problems, eye issues, and heart disease.

Who should not take Combose 0.5 Tablet?

Combose 0.5 Tablet should not be taken by people if they have type 1 diabetes, severe liver disease, diabetic ketoacidosis, a blocked intestine, or are allergic to any of its ingredients. It is also not recommended for people under 18 years or over 75 years of age.

Can Combose 0.5 Tablet cause low blood sugar (hypoglycemia)?

Yes. Combose 0.5 Tablet can sometimes lower your blood sugar too much, especially if you skip meals, exercise more than usual, or take it with certain other medicines. Signs of low blood sugar include sweating, dizziness, fast heartbeat, shakiness, and confusion.

What are the serious side effects of Combose 0.5 Tablet?

Serious side effects of Combose 0.5 Tablet may include severe allergic reactions (swelling, difficulty breathing, fast heartbeat), chest pain, liver problems, or loss of consciousness due to very low blood sugar. If you experience any of these symptoms, seek immediate medical attention.

Can Combose 0.5 Tablet cause heart problems?

There have been reports suggesting a possible increased risk of acute coronary events with repaglinide (present in Combose 0.5 Tablet) in some studies. If you develop chest pain or other heart symptoms, seek urgent medical attention and tell your doctor you take this medicine.

Can Combose 0.5 Tablet cause problems in people with bowel or intestinal conditions?

Yes. Voglibose, present in Combose 0.5 Tablet, is not suitable for people with gastrointestinal obstruction or a predisposition to it, and it can cause increased intestinal gas that may worsen certain gut conditions. Tell your doctor if you have had bowel surgery, chronic intestinal disease, or symptoms of obstruction.

Fact Box

Habit Forming

Therapeutic Class

ANTI DIABETIC

Related lab tests

Glucose - Fasting Blood

Glucose - Postprandial Blood

Glycosylated Hemoglobin

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: ADN Life Sciences
Address: 1203 Rajsarover, Off Link Road, Borivali West, Borivali West, Mumbai-400068, Maharashtra, India

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Combose 0.5 Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Combose Tablet

Benefits of Combose Tablet

Side effects of Combose Tablet

How to use Combose Tablet

How Combose Tablet works

All substitutes for Combose 0.5 Tablet

Vogli-Rapid 0.3/0.5 Tablet

Eurepa-V 0.5/0.3 Tablet

Volibo R 0.5mg/0.3mg Tablet

Volga R 0.5mg/0.3mg Tablet

Volix R 0.5mg/0.3mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Combose 0.5 Tablet used for?

Can Combose 0.5 Tablet cure diabetes?

Who should not take Combose 0.5 Tablet?

Can Combose 0.5 Tablet cause low blood sugar (hypoglycemia)?

What are the serious side effects of Combose 0.5 Tablet?

Can Combose 0.5 Tablet cause heart problems?

Can Combose 0.5 Tablet cause problems in people with bowel or intestinal conditions?

Fact Box

Habit Forming

Therapeutic Class

Related lab tests

Glucose - Fasting Blood

Glucose - Postprandial Blood

Glycosylated Hemoglobin

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests