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Combo-L Capsule SR

Written By Dr. Syeda Aafia, MBA, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 25 Nov 2025 | 10:34 PM (IST)
Combo-L Capsule SR is a prescription medicine which is used in the treatment of gastroesophageal reflux disease (acid reflux), intestinal ulcers, and irritable bowel syndrome. It reduces excess acid production in the stomach and prevents the reflux of stomach acid into the food pipe.
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Combo-L Capsule SR
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Renvorab-SL Capsule SR
Renvorab-SL Capsule SR
strip of 10 capsule sr
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Combo-L Capsule SR image
Combo-L Capsule SR image

Product introduction

Combo-L Capsule SR is taken with or without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effects are nausea, stomach pain, diarrhea, flatulence, constipation, headache, weakness, and flu-like symptoms. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your sleepiness.

Lifestyle modifications like having fiber-rich diet, avoiding foods that trigger your symptoms, increasing fluid intake and regular exercise can help you to get better results. Before taking it, you should tell your doctor if you have any kidney or liver diseases. You should also tell your doctor if you are pregnant, planning pregnancy or breastfeeding.

Benefits of Combo-L Capsule SR

Treatment of Intestinal ulcers
Intestinal ulcers are painful sores that develop in the inner lining of the stomach or gut (intestine). Combo-L Capsule SR reduces the amount of acid your stomach makes which prevents further damage to the ulcer as it heals naturally. You may be given other medicines along with this medicine depending on what caused the ulcer. You need to keep taking Combo-L Capsule SR as prescribed by the doctor for it to be effective, even if the symptoms seem to disappear.
Treatment of Irritable bowel syndrome
Irritable bowel syndrome is a chronic (long-term) inflammatory disease of the large intestine (colon) that usually needs long term management. This can lead to bleeding, frequent diarrhea, bloating, flatulence, cramps and stomach pain. Combo-L Capsule SR relaxes the muscles in your stomach and gut (intestine) and relieves these symptoms effectively. Usually, it is used along with other medicines for management of your condition.
Continue taking it for as long as the doctor may advise you to. You need to take this medicine regularly to get the most out of it. Take a fiber-rich diet, avoid oily or spicy food and drink plenty of fluids while taking it to make sure you stay hydrated.
Treatment of Gastroesophageal reflux disease (Acid reflux)
Gastroesophageal reflux disease (GERD) is a chronic (long-term) condition in which there is an excess production of acid in the stomach. Combo-L Capsule SR reduces the amount of acid your stomach makes and relieves the pain associated with heartburn and acid reflux. You should take it exactly as it is prescribed for it to be effective.
Some simple lifestyle changes can help reduce the symptoms of GERD. Think about what foods trigger heartburn and try to avoid them; eat smaller, more frequent meals; try to lose weight if you are overweight and try to find ways to relax. Do not eat within 3-4 hours of going to bed.

Side effects of Combo-L Capsule SR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Combo-L
  • Weakness
  • Flatulence
  • Vomiting
  • Nausea
  • Abdominal pain
  • Diarrhea
  • Headache
  • Dizziness
  • Cough
  • Breast enlargement in male
  • Drowsiness
  • Altered libido
  • Absence of menstrual periods
  • Unusual production of breast milk in women and men
  • Back pain

How to use Combo-L Capsule SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Combo-L Capsule SR is to be taken on an empty stomach.

How Combo-L Capsule SR works

Levosulpiride is a prokinetic which works by increasing the release of acetylcholine (a chemical messenger). This increases the movement of stomach and intestines, and prevents reflux (acid going up to the food pipe). Rabeprazole is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in the relief of acid-related indigestion and ulcers.

Quick tips

  • Take it one hour before the meal, preferably in the morning.
  • Inform your doctor if you get watery diarrhea, fever, or stomach pain that does not go away.
  • Do not consume alcohol while taking Combo-L Capsule SR as it can increase the risk of stomach damage.
  • Long-term use may cause weak or broken bones. Take adequate intake of dietary calcium and vitamin D or their supplements. Do not take Combo-L Capsule SR for longer than prescribed.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Combo-L Capsule SR may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

UNSAFE
Combo-L Capsule SR is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

UNSAFE
Combo-L Capsule SR is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving

Driving

UNSAFE
Combo-L Capsule SR may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Combo-L Capsule SR should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

UNSAFE
Combo-L Capsule SR is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

Take the Combo-L Capsule SR exactly as directed by your doctor. It is best to take one capsule daily on an empty stomach.
Use of Combo-L Capsule SR should be avoided in patients with known allergy to any of the components or excipients of this medicine.
Yes, the use of Combo-L Capsule SR can cause dizziness (feeling faint, weak, unsteady or lightheaded) in some patients. If you feel dizzy or lightheaded, it is better to rest for sometime and resume once you feel better.
Several studies in adults suggest that treatment with Combo-L Capsule SR may be associated with an increased risk of osteoporosis-related fractures of the hip, wrist or spine. The risk of fracture was increased in patients who received high dose. High dose can mean multiple daily doses, and long-term therapy (a year or longer).
No, taking Combo-L Capsule SR may make you feel sleepy, dizzy or could affect your eyesight. So do not drive or use machines until you know how this medicine affects you.
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Fact Box

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: P R G Pharma Pvt Ltd
Address: 305,3rd Floor, Progressive House, Rohit Kunj, Pitampura,Delhi-110034 , India

Vendor Details

Country of origin: India
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