Bific 300mg Injection is an antibiotic that is used to treat complicated urinary tract infections. It works by killing the bacteria thereby stopping their growth. The dose of this medication will depend on the age and symptoms of individual patients.
Bific 300mg Injection is given as an injection by a doctor or a nurse; do not self-administer. It should be used for the minimum period necessary to prevent the development of resistant bacteria.
The most common side effects of this medicine include rash; pruritus; eosinophilia; gastrointestinal distress (diarrhea, nausea); and increased alanine transaminase, aspartate transaminase, and alkaline phosphatase. These side effects are usually temporary and go away as your body adjusts to the medicine. However, consult your doctor if the side effects persist or worsen.
Bific 300mg Injection should be used with caution in patients who have a known history of allergy to other antibiotics (such as carbapenems, penicillins, and cephalosporins) and in those with a history of epilepsy and other central nervous system disorders. Let your doctor know if you are receiving sodium valproate as part of your medication, as Bific 300mg Injection may decrease blood levels of valproic acid and cause epileptic seizures. While on treatment with this medicine, your doctor may also advise blood tests to monitor your kidney function. Pregnant and breastfeeding women should also consult their doctors before using this medicine.
Bific 300mg Injection helps treat urinary tract infections (UTIs) by targeting and eliminating a wide range of bacteria, including strains that may not respond to commonly used antibiotics. It works quickly to reduce infection-related symptoms such as fever, pain, and urinary discomfort, allowing faster recovery. The medicine is especially useful in moderate to severe UTIs or when the infection is caused by resistant organisms, helping prevent complications and supporting the body’s return to normal urinary function.
Side effects of Bific Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Bific
Rash
Itching
Diarrhea
Nausea
Increased alanine aminotransferase
Increased aspartate aminotransferase
Increased alkaline phosphatase level in blood
Increased white blood cell count (eosinophils)
How to use Bific Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Bific Injection works
Bific 300mg Injection inhibits bacterial cell wall synthesis and kills the bacteria.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Bific 300mg Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Information regarding the use of Bific 300mg Injection during pregnancy is not available. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Bific 300mg Injection during breastfeeding is not available. Please consult your doctor.
Driving
CONSULT YOUR DOCTOR
It is not known whether Bific 300mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney
CONSULT YOUR DOCTOR
There is limited data available on the use of Bific 300mg Injection in patients with kidney disease. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited data available on the use of Bific 300mg Injection in patients with liver disease.
What if you forget to take Bific Injection?
If you miss a dose of Bific 300mg Injection, consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Inform your doctor if you have a history of epilepsy and are on medications like sodium valproate because Bific 300mg Injection may reduce the levels of valproic acid and also result in the recurrence of epileptic seizures.
Let your doctor know if you have severe kidney disease before starting the treatment with Bific 300mg Injection.
Along with taking this medicine, maintain personal hygiene and drink an adequate amount of water.
Inform your doctor if you have a history of epilepsy and are on medications like sodium valproate because Bific 300mg Injection may reduce the levels of valproic acid and also result in the recurrence of epileptic seizures.
Let your doctor know if you have severe kidney disease before starting the treatment with Bific 300mg Injection.
Along with taking this medicine, maintain personal hygiene and drink an adequate amount of water.
Having urine infection since about a month. Took several antibiotics after consultation with doctor but they all show effect only for starting 2 days and then that antibiotic doesn't work. I have taken sporidex 500, zefu cv 500, norflox 400, levofloxin, cefodoxime (each taken for atleast 4-5 days). All work for starting two days then no effect and infection starts to increase. Urine culture report is attached. Kindly suggest medication since problem is increasing day by day.
Dr. Ila Jain Khandelwal
Pathology
You should consult a urologist and get a few tests done since we need to know the cause of your recurrent urinary tract infections.
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References
Vora A, Tiwaskar M. Biapenem. J Assoc Physicians India. 2022 Jan;70(1):11-12. [Accessed 05 Jan. 2026]. Available from: