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PhD (Pharmacology), PGDPRA
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MD (Pharmacology), MBBS
Last updated:
15 Jul 2019 | 05:17 PM (IST)
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ANACOX-PLUS 450MG/300MG TABLET is a combination of two medicines. It is prescribed to treat Tuberculosis. It fights against the bacteria to kill them.

ANACOX-PLUS 450MG/300MG TABLET is a prescription medicine. It can be taken with or without food. Take the medicine in the dose and duration advised by your doctor. Do not consume more than the recommended dose, as this may have harmful effects on your body. A missed dose should be taken as soon as you remember. The course of the treatment should be completed for better efficacy.

Some of the side effects of ANACOX-PLUS 450MG/300MG TABLET are nausea, vomiting, rashes, etc. You may also feel dizzy, thus it is advised not to drive or operate machinery. To overcome dizziness you should drink plenty of fluid. If any of the side effects get aggravated, contact your doctor immediately. In cases of severe liver or kidney disease, consult your doctor before you start with the treatment. Consumption of alcohol should be avoided while you are on the treatment.

Uses of Anacox-Plus Tablet

Side effects of Anacox-Plus Tablet

  • Dark colored urine
  • Rash
  • Vomiting
  • Jaundice
  • Fever
  • Increased liver enzymes
  • Nausea
  • Peripheral neuropathy (tingling and numbness of feet and hand)

How to use Anacox-Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. ANACOX-PLUS 450MG/300MG TABLET is to be taken empty stomach.
Avoid ANACOX-PLUS 450MG/300MG TABLET with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How Anacox-Plus Tablet works

ANACOX-PLUS 450MG/300MG TABLET is a combination of two antibiotics: Rifampicin and Isoniazid, which treats tuberculosis (TB). Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Isoniazid prevents these bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.

Safety Advice

Consuming alcohol while taking ANACOX-PLUS 450MG/300MG TABLET may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
ANACOX-PLUS 450MG/300MG TABLET may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
ANACOX-PLUS 450MG/300MG TABLET is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
ANACOX-PLUS 450MG/300MG TABLET may cause side effects which could affect your ability to drive.
ANACOX-PLUS 450MG/300MG TABLET can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability.
ANACOX-PLUS 450MG/300MG TABLET should be used with caution in patients with kidney disease. Dose adjustment of ANACOX-PLUS 450MG/300MG TABLET may be needed. Please consult your doctor.
ANACOX-PLUS 450MG/300MG TABLET should be used with caution in patients with liver disease. Dose adjustment of ANACOX-PLUS 450MG/300MG TABLET may be needed. Please consult your doctor.
Use of ANACOX-PLUS 450MG/300MG TABLET is not recommended in patients with severe liver disease.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Quick Tips

  • You have been prescribed ANACOX-PLUS 450MG/300MG TABLET for the treatment of tuberculosis.
  • Finish the full course of the medication, even if you feel better. Stopping it early may make the infection come back.
  • Take it on an empty stomach, preferably at the same time everyday.
  • It may discolour your urine, sweat, saliva and tears a reddish-orange colour. This is normal and not harmful.
  • Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
  • Avoid drinking alcohol while taking ANACOX-PLUS 450MG/300MG TABLET as this may increase the risk of side effects on the liver.
  • Use an alternative or additional contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking ANACOX-PLUS 450MG/300MG TABLET as it may make hormonal contraceptives such as the pill less effective.
  • Do not take indigestion remedies (antacids)  within at least two hours of taking ANACOX-PLUS 450MG/300MG TABLET.

Patient Concerns

last year APRIL 2017 i am suffered from tuberculosis and the medicine Megacox Plus 1 tab a day is running. and this month end my treatement is completed as per my doctor. at present i am over weight and trying to do work out from a month and taking low calorie and low fat diet but still unable to loose my weight even of 100 gm. moreover my breathing power and stamina is also very low and feeling low energy also. please give your suggestion and prescribed any medication if required.
Dr. Saurav Arora
The weight reduction depends upon many factors, including family, personal and medical history. Over weight may be due to lifestyle disorders, bad eating habits and other chronic diseases. For effective weight reduction the concentration should be primarily on natural ways. Therefore, please consult a dietician and a trainer for taking guidance for food and exercise. In homeopathy, you can take Phytolacca berry tabs, 2 tab thrice daily for a month and observe the changes. For Do?s and Don?ts while taking homeopathic medicines visit
My brother is on medications of spinal Tuberculosis from sep till present. Can dolokind plus be used for vomiting & fever?
Dr. Sfurti Mann
Diabetes Specialist
Yes However consult ur physician to check for anti TB medicines side effects if any
Do you have any questions related to ANACOX-PLUS 450MG/300MG TABLET ?


Q. What are the instructions for storage and disposal of Anacox-Plus?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. What is Anacox-Plus?

Anacox-Plus is a combination of two medicines: Rifampicin and Isoniazid. It is used in the treatment of tuberculosis. Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by tuberculosis bacteria to make essential proteins and reproduce. Isoniazid prevents the tuberculosis causing bacteria from forming their own protective covering. Together, they kill the bacteria and eradicate the infection.

Q. What is the most important information I should know about the Anacox-Plus?

Take the proper course of drug that has been prescribed to you. Do not stop in between even if you begin to feel better. Avoid alcohol while taking this medicine as it increases the risk of damage to your liver during treatment. Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.

Q. What is the best time to take Anacox-Plus?

Take Anacox-Plus exactly as directed by your doctor. It is best to take the medicine on an empty stomach one hour before or two hours after meals.

Q. Does Anacox-Plus cause change in urine color/turn urine orange?

Yes, Anacox-Plus can change the color of your urine (skin, sweat, saliva, tears and feces) to brownish-red or orange. This effect is not harmful.

Q. Does the use of Anacox-Plus make birth control pills ineffective?

Yes, Anacox-Plus can make birth control pills less effective. So, ask the doctor about using a birth control method which does not affect your hormone levels (such as a condom, diaphragm and spermicide).

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
  1. Isoniazid/rifampicin. Guildford Surrey: Aventis Pharma Limited; 1999 [revised 12 Mar. 2019]. [Accessed on 10 Apr. 2019] (online) Available from:External Link
  2. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Hilal-Dandan R, Brunton LL. Goodman and Gilman's Manual of Pharmacology and Therapeutics. 2nd ed. New York, New York: The McGraw-Hill Companies, Inc.; 2014. [Accessed 10 Apr. 2019] (online) Available from:External Link
  3. Isoniazid. Nottingham, Nottinghamshire: Boots Contract Manufacturing; 2015. [Accessed 10 Apr. 2019] (online) Available from:External Link
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