A psychotropic drug is a medicine affecting the mind, emotions, and behaviour. Almantin has a beneficial effect on the behavioural symptoms of patients with moderate to severe Alzheimer's Disease. Therefore it is considered as a psychotropic agent.
No. Almantin is not a narcotic. It does not have habit forming potential.
No. Mood stabilisers are used to treat mania and bipolar disorder. Almantin is not approved for these conditions yet, although studies are going on for the role of Almantin in these diseases also.
No. Almantin does not fit in the generally accepted "Nootropic" descriptor for healthy people. Nootropics are drugs which increase cognition/ motivation/ creativity in healthy individuals. Almantin, on the other hand, improves cognition in patients with Alzheimer's Disease.
Q. Is Almantin a cholinesterase inhibitor?
No. Almantin does not function by inhibiting the cholinesterase enzyme found in the endings of nerve cells. Rather, it acts by preventing the toxicity of an excitatory substance called glutamate in the brain.
Yes. Almantin acts as an antagonist at the NMDA receptor. This is the receptor in the brain through which glutamate, an excitatory substance, damages the nerve cells in the brain, which is found in Alzheimer's disease.
Cmax (Peak plasm concentration) of Almantin is 35-40 ng/ml.
Q. Can I take Almantin with vitamin D?
It has been reported in some studies that a combination of Almantin and Vitamin D improves cognition in Alzheimer's Disease. However, more studies are required to confirm this finding.
Q. Can I take Almantin with vitamin E?
Some studies have reported that among patients with mild to moderate Alzheimer's disease, taking alpha-tocopherol (Vitamin E) with Almantin slows the progressive functional decline. However, more studies are required to confirm this finding.
Almantin is started when a person starts suffering from moderate to severe Alzheimer's Disease and has failed other options. Despite years of research for mild Alzheimer's Disease, Almantin has not been found to be useful in it.
Almantin is prescribed to improve the cognitive (memory) function in patients with Alzheimer's Disease when other treatment options like cholinesterase enzyme inhibitors have failed.
Q. What is the interaction of Almantin with metformin?
The interaction between Almantin and Metformin is minor. Almantin oral increases the level or effect of metformin by nonacidic drugs competing for the same pathway through the kidney.
Q. What is the interaction of Almantin with warfarin?
No known interaction between Almantin and Warfarin has been found.
The role of Almantin in Lewy Body Dementia (LBD) is controversial. Some studies suggest that it is safe and efficacious in this disease whereas others have shown exacerbation of LBD due to Almantin. Almantin is not approved for use in Lewy Body Dementia.
Q. Can Almantin combined with donepezil?
A combination of Almantin and Donepezil can be given in moderate to severe Alzheimer's Disease. It has been shown that the combination may have additive effects i.e. effects of both drugs are added when given together in some studies.
Q. Can Almantin be used with rivastigmine?
Almantin in combination with rivastigmine is safe and beneficial in patients with Alzheimer's Disease. Patients have improvement or stabilisation on dual therapy.
Almantin is not indicated for use in chronic pain. It has been proposed as a medication for the treatment of neuropathic pain for its mechanism, safety, lack of serious adverse effects, and the relatively rapid onset of action. However, studies have not been promising so far and its routine use in neuropathic pain is not currently recommended.
Almantin is not indicated for use in Opioid withdrawal. In a number of small studies, it has been seen that Almantin decreased the expression of opioid physical dependence in humans but there is a need for more studies in this field.
Almantin has failed to demonstrate clinical efficacy in autism. Studies are currently in progress for other clinical applications.
Almantin has failed to demonstrate clinical efficacy in vascular dementia although it was well-tolerated.