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PhD (Pharmacology), PGDPRA
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Last updated:
02 Mar 2020 | 04:54 PM (IST)
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Overview

Introduction

Akurit 4 Tablet is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection.

Akurit 4 Tablet is a prescription medicine and it is to be taken it as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve.

Some common side effects of this medicine are nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, etc. To cope up with the side effects, you should drink plenty of water. If any of the side effects get aggravated, you must consult your doctor immediately. Generally, serious side effects are rare. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.

Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Patients with liver and kidney ailments must take this medicine with proper consultation and caution. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. During the treatment, you must take adequate rest and eat a healthy diet for a faster recovery. While on the medication, your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.

Uses of Akurit 4 Tablet

Side effects of Akurit 4 Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Akurit 4

  • Nausea
  • Vomiting
  • Rash
  • Fever
  • Dark colored urine
  • Sweating
  • Increased sputum production
  • Salivation
  • Watery eyes
  • Peripheral neuropathy (tingling and numbness of feet and hand)
  • Increased liver enzymes
  • Jaundice
  • Increased uric acid level in blood
  • Visual impairment

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Vomiting
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Rash
    There are many treatments for a wide range of skin problems. Avoid hot showers or baths because hot water can irritate the skin. Make sure to pat dry your skin after a bath or shower. Do not rub or scratch the affected area. Leave the skin exposed to the air as much as possible. Do not use perfumed soaps or deodorants. Water containing chlorine can make most skin problems worse, so avoid swimming. Avoid spicy foods, alcohol, tobacco smoke and caffeine as it may also make itching worse. Avoid excessive sun exposure. Always use sunscreen and protective clothing when outdoors. Moisturizers can be used regularly to soothe and hydrate the affected area. If it does not get better within a week, speak to a pharmacist or doctor.
  • Coping with Sweating
    Try wearing loose, light-weighted, and breathable clothing. Use a strong antiperspirant and keep yourself cool with a fan. Changing your shoes and socks often might also help. Try cutting down on coffee, tea, and alcohol as they can increase your body temperature and promote sweating. Avoid spicy foods, this will help you deal with excessive sweating. If this does not help, talk to your doctor about other possible medications.
  • Coping with Increased liver enzymes
    There may be no symptoms, so your doctor should carry out a blood test and give you advice. Some lifestyle changes can bring down levels of liver enzymes. In general, you will need to stop drinking alcohol or limit the amount you drink, lose weight and keep active. Drink plenty of fluids to avoid dehydration. Eat a healthy diet. Some particular foods like nuts, fatty fish, coffee, tea, olive oil, sprouts and bananas may be beneficial. Try to control stress as this can make your symptoms worse.

How to use Akurit 4 Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Akurit 4 Tablet is to be taken empty stomach.
Avoid Akurit 4 Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

How Akurit 4 Tablet works

Akurit 4 Tablet is a combination of four medicines: Isoniazid, rifampicin, ethambutol and pyrazinamide which treat tuberculosis. Isoniazid works by preventing the TB bacteria from forming their own protective covering, while rifampicin inactivates a bacterial enzyme (RNA-polymerase) which is required by TB bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Ethambutol and pyrazinamide on the other hand, work by slowing the growth of these bacteria.

Safety Advice

Alcohol
UNSAFE
Consuming alcohol while taking Akurit 4 Tablet may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Pregnancy
CONSULT YOUR DOCTOR
Akurit 4 Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
SAFE IF PRESCRIBED
Akurit 4 Tablet is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
UNSAFE
Akurit 4 Tablet may cause side effects which could affect your ability to drive.
Akurit 4 Tablet occasionally causes sight problems and tingling or numbness in hand or feet. After taking this medicine you should not drive until you know how it affects you.
Kidney
CAUTION
Akurit 4 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Akurit 4 Tablet may be needed. Please consult your doctor.
Kidney function tests are advisable before the start of this medicine.
Liver
CAUTION
Akurit 4 Tablet should be used with caution in patients with liver disease. Dose adjustment of Akurit 4 Tablet may be needed. Please consult your doctor.
Regular monitoring of liver function tests is advised before and after the start of the treatment.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Akurit 4 Tablet
₹6.84/Tablet
MONITOR 4 TABLET
Shreya Life Sciences Pvt Ltd
₹3.99/Tablet
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Mycurit 4 mg Tablet
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₹4.77/Tablet
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Trac 4 Tablet
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₹5.67/Tablet
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Coxcure 4 Tablet
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₹5.95/Tablet
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Quick Tips

  • You have been prescribed Akurit 4 Tablet for the treatment of tuberculosis.
  • Take it on an empty stomach and preferably at the same time everyday.
  • Try not to forget a dose, as this increases the risk of the bacteria becoming resistant to the medicine, and also increases the risk of getting side effects.
  • It may discolour your urine, sweat, saliva and tears a reddish/orange colour. This is normal and not harmful.
  • Your doctor may check your liver function before starting treatment and regularly thereafter. Inform your doctor if you notice yellowing of eyes or skin, dark urine, or stomach pain.
  • Avoid drinking alcohol while taking Akurit 4 Tablet as this may increase the risk of side effects on the liver.
  • It may cause vitamin B6 deficiency. Your doctor may prescribe vitamin B6 supplements to help avoid potential problems associated with its deficiency, such as inflammation of the nerves (neuritis). 
  • Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Akurit 4 Tablet as it may make hormonal contraceptives such as the pill less effective.
  • Do not take indigestion remedies (antacids)  within at least two hours of taking Akurit 4 Tablet.
  • Finish the full course of the medication, even if you feel better. Stopping the course early increases the risk of coming back of the infection.

Fact Box

Habit Forming
No

Patient Concerns

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I am suffering with TV dieses since from 4 months I have started TV dieses prevention course with 4 months back accomplish with Akurit 4 medicine after taking Akurit 4 continually for 4 months than switch in Akurit 3 so I just wanted to know is there any harm in take Akurit 4 for 4 months
Dr. Mehtab Baig
Orthopaedic Physiotherapy
No, its need for u now
She is on anti TB drugs since last 5 months 10 days , for initial two months she was taking forecox 2 tabs, thereafter she is continuing akurit 3 , 3 tablet, but some other advised us to take only one tab r cinex 450,so please advice
Dr. Anshum Aneja Arora
Pulmonology
akurit 3 must be taken in continuation phase
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Do you have any questions related to Akurit 4 Tablet ?

User Feedback


FAQs

Q. Can the use of Akurit 4 cause discoloration of the urine?

Yes, Akurit 4 contains Rifampicin. It can cause temporary discoloration of your teeth, sweat, urine, saliva and tears (red, orange or brown color). This side effect is usually not harmful. However, discoloration of urine can be a sign of liver damage. Contact your doctor if you notice discoloration of urine accompanied with stomach pain, loss of appetite and jaundice (yellowing of your skin or eyes).

Q. Can Akurit 4 cause visual impairment?

Akurit 4 contains Ethambutol which may cause visual impairment. Inform the doctor immediately if you notice any changes in your eyesight.

Q. Can I discontinue Akurit 4 if I feel well?

No, do not discontinue Akurit 4. Take the proper course of a drug that has been prescribed for you even if you begin to feel better. If you stop taking Akurit 4 then your infection may become worse, difficult to treat and it may result in drug-resistant TB (drugs you are taking may no longer work).

Q. Can I take oral contraceptive pills while taking Akurit 4?

No, Akurit 4 can make birth control pills less effective. So, ask your doctor about using a birth control method which does not affect your hormone levels (such as a condom, diaphragm, spermicide).

Q. What are the instructions for storage and disposal of Akurit 4?

Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. How to take Akurit 4?

Take Akurit 4 on an empty stomach which means at least one hour before and two hours after a meal and with full glass of water.

Q. Can I drink alcohol while taking Akurit 4?

No, avoid drinking alcohol while taking Akurit 4. Drinking alcohol will increase the risk of hepatitis caused by Akurit 4 because of isoniazid.

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Disclaimer:

1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Gumbo T. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman's: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: The McGraw-Hill Companies, Inc.; 2011. [Accessed 09 Apr. 2019] (online) Available from:External Link
  2. Drugs.com. Rifampicin. [Accessed 09 Apr. 2019] (online) Available from:External Link
  3. Ethambutol. Ontario, Canada: Patheon Inc.; 2007. [Accessed 09 Apr. 2019] (online) Available from:External Link
  4. Drugs.com. Pyrazinamide. [Accessed 09 Apr. 2019] (online) Available from:External Link

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