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MD (Pharmacology), MBBS
Last updated:
16 Oct 2019 | 01:31 PM (IST)
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Aculip 25 mg/10 mg Tablet


Overview

Introduction

Aculip 25 mg/10 mg Tablet is a combination of two medicines. It is used in the treatment of depression associated with anxiety. It helps in regulating mood and to reduce anxiety.




Aculip 25 mg/10 mg Tablet is taken with or without food. However, it is advisable to take it at a fixed time each day to maintain consistent level of medicine in the blood. In case you miss a dose of this medicine, take it as soon as you remember. Never skip any dose and finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may worsen your symptoms. Taking this medicine for long time may require regular monitoring of blood and liver functions.

Some common side effects of this medicine include insomnia, agitation, anxiety and a feeling of worthlessness. This medicine may cause weight loss. So, in case you lose weight, consult a dietitian for dietary supplement or try to increase your food portion. Remember to inform your doctor if you develop any unusual changes in mood as it may lead to suicidal thoughts.

Uses of Aculip Tablet

Side effects of Aculip Tablet

Common
  • Constipation
  • Difficulty in urination
  • Weight gain
  • Confusion
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Tiredness
  • Blurred vision
  • Dryness in mouth
  • Increased heart rate
  • Uncoordinated body movement
  • Depression
  • Memory impairement

How to use Aculip Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Aculip 25 mg/10 mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Aculip Tablet works

Aculip 25 mg/10 mg Tablet is a combination of two medicines: Amitriptyline and Chlordiazepoxide, which treats depression. Amitriptyline is a tricyclic antidepressant which increases the levels of chemical messengers in the brain that help in regulating the mood and treat depression. Chlordiazepoxide is a benzodiazepine (BZD) which works by increasing the action of GABA, a chemical messenger which suppresses the abnormal and excessive activity of the nerve cells in the brain.

Safety Advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Aculip 25 mg/10 mg Tablet.
Pregnancy
CONSULT YOUR DOCTOR
Aculip 25 mg/10 mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Aculip 25 mg/10 mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Aculip 25 mg/10 mg Tablet may cause side effects which could affect your ability to drive.
As Aculip 25 mg/10 mg Tablet may make you feel drowsy or affect your concentration and this may affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Aculip 25 mg/10 mg Tablet is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Aculip 25 mg/10 mg Tablet may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Aculip 25 mg/10 mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Aculip 25 mg/10 mg Tablet may be needed. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Aculip 25 mg/10 mg Tablet
₹4.35/Tablet
₹5.2/Tablet
19% costlier
Amixide 10mg Tablet
Sun Pharmaceutical Industries Ltd
₹5/Tablet
15% costlier
₹2.42/Tablet
save 44%
Mytrip Plus Tablet
Mayflower India
₹3.1/Tablet
save 29%
Relidep Plus 25 mg/10 mg Tablet
Reliance Formulation Pvt Ltd
₹4.1/Tablet
save 6%

Patient Concerns

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Sir i have taken the medicine of depression tablet ventab 25 mg prponol 10 mg nixodre plus i am feeling very tired and i wanted to concieved as soon as possoble is it write please give advice aboit this. When i have to try to conceive does any side effect on baby please suggest me i have taken these medicine from 3 to 4 month but there is no any improment y health how to overcome from this problem please reply me
Dr. Jyoti Kapoor Madan
Psychiatrist
You shouldn't plan pregnancy while you are on psychotropics, they can harm the foetus, especially during the first three months of conception. Pregnancy can also increase the risk to increasing depression. A reasonable solution is to get adequate treatment and go for psychotherapy, after you have recovered from depression, gradually withdraw medicines and continue therapy before planning conception. For further guidance, visit your psychiatrist.
Hello sir i have taking the tablet of depression from three month this desease come out from dengue now i have taking ventab 25 mg proponol 10 mg and clozepam . 50mg but when i get off it again i feel anxient and sad. I feel freqeunt in mind only when i miss one or two days dose. I wanted to know that we will i stop these medicine i also wanted to get pregnant but due to this tablets i miss this chance sir please help me when will i conceive because have no baby and wanted to plan for this
Dr. Sunil Sekhri
Diabetes Specialist
you have been diagnosed with depression as told by you. It is a treatable condition. your re already undergoing medical therapy and you consult your Doctor to add Psychotherapy but this decision has to be made by your treating doctor
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Do you have any questions related to Aculip 25 mg/10 mg Tablet ?

User Feedback


FAQs

Q. What are the instructions for storage and disposal of Aculip?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Q. Are there any important warnings associated with use of Aculip?

During the first few months of treatment, Aculip may increase suicidal thoughts or actions in some patients. Patients having mood or behavioral disorder have a high risk of developing suicidal thoughts and actions. You should pay close attention and report your doctor of any such behavior or mood changes. Make sure that you visit the doctor for the scheduled follow-up appointments.

Q. Can I stop taking Aculip when my symptoms are relieved?

No, you should continue to take Aculip, even if you feel well. If you stop Aculip suddenly, serious withdrawal symptoms may occur. Consult your doctor if the symptoms are relieved, he might decrease your dose gradually.

Q. How to manage weight gain associated with the use of Aculip?

There are reports which suggest that the use of Aculip can cause weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight. An important to remember is that it is easier to prevent weight gain than losing increased weight.

Q. Can the use of Aculip cause sleepiness?

Yes, Aculip can make you feel sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities till you know how this medicine affects you.

Q. Can the use of Aculip affect my sexual life?

The use of Aculip can affect the sexual life of both men and women. Most commonly caused problems are decreased sexual desire, erectile dysfunction (inability to develop or maintain erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort while having sex. If you experience these problems, discuss with your doctor.

Q. Can I drink alcohol while taking Aculip?

No, do not drink alcohol while you are taking Aculip. Drinking alcohol can increase the severity of drowsiness or sleepiness caused by Aculip.

Q. Can the use of Aculip change the color of urine?

Yes, Aculip can the change the color of the urine to blue or green. This change of color is expected while using Aculip, and it is not harmful. Your urine color becomes normal once you stop taking Aculip.

Q. How long does Aculip take to work?

Everybody responds differently to the treatment. In general, it can take several weeks to feel the full benefits of Aculip, although some people will start to feel better sooner. When taking Aculip, it is important to give it time to work.

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Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. DailyMed. Chlordiazepoxide and amitriptyline hydrochloride. [Accessed 10 Apr. 2019] (online) Available from:External Link
  2. Amitriptyline. North Harrow, Middlesex: Accord Healthcare Limited; 2018. [Accessed 10 Apr. 2019] (online) Available from:External Link
  3. MedlinePlus. Chlordiazepoxide. [Accessed 10 Apr. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
308-310 Dwarkesh Complex, Sun Pharma Road, Po:Atladra, Vadodara-390 012., Gujarat, India.
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