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Pigolyn 0.2% Cream

Trioxsalen (20gm)
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Authenticity Assured
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Pigolyn 0.2% Cream is a medicine used in the treatment of vitiligo and psoriasis. It reduces the overproduction of skin cells and helps to re-pigment the discolored, white patches.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 21 Apr 2026 | 04:38 PM (IST)
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General Information

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Product introduction

Pigolyn 0.2% Cream is for external use only. Use It only under the direct supervision of your doctor. The affected area should be clean and dry before application. You must wash your hands thoroughly before and after applying this medicine. This medicine should be used regularly to get the most benefit from it. Do not use more than you need as it will not clear your condition faster and some side effects may be increased. If your condition goes on for longer than four weeks or gets worse at any time, let your doctor know. You can help this medication work better by keeping the affected areas clean.

Common side effects include burning, itching, irritation, and redness at the site of injection. It may also cause blisters on your skin. Please consult your doctor if these side effects persist for a longer duration. Avoid direct contact with your eyes. In case of accidental contact, wash your eyes with plenty of water and seek immediate medical attention.

Application of Pigolyn 0.2% Cream can make your skin sensitive to sunlight. Avoid exposure to sunlight. Use sunscreens and cover yourself with protective clothing for at least 8 hours after treatment. Avoid eating certain foods like limes, figs, parsley, parsnips, mustard, carrots, and celery, as they may increase the skin's sensitivity to light.

Uses of Pigolyn Cream

Benefits of Pigolyn Cream

Psoriasis
Psoriasis causes thick, scaly patches on the skin along with itching and irritation. Pigolyn 0.2% Cream helps slow down the excessive growth of skin cells when used with light therapy, which reduces scaling, redness, and discomfort, leading to clearer and healthier-looking skin.
Vitiligo
Vitiligo is a condition where patches of skin lose their natural color due to reduced pigment. Pigolyn 0.2% Cream helps restore pigmentation by increasing the skin’s sensitivity to light, which supports the repigmentation process and improves the appearance of affected areas.

Side effects of Pigolyn Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Pigolyn
  • Erythema (skin redness)
  • Blisters on skin
  • Edema (swelling)
  • Itching
  • Application site reactions (burning, irritation, itching and redness)

How to use Pigolyn Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Pigolyn Cream works

Pigolyn 0.2% Cream is a photosensitive medication used with UV-A rays. It works by activating certain skin cells (melanocytes) and helps repigment the discolored, white patches in vitiligo. Pigolyn 0.2% Cream also slows down the rapid growth of skin cells in psoriasis. This reduces scaling and thickening of the skin.

Quick tips

  • Pigolyn 0.2% Cream is given for the treatment of skin disorders like vitiligo and psoriasis. 
  • Take this treatment (Pigolyn 0.2% Cream and UVA) two or three times a week with the treatment spaced at least forty-eight hours apart.
  • Do not increase the amount of Pigolyn 0.2% Cream if you are spending extra time in the sunlight or under an ultraviolet lamp.
  • Use sunscreen with your doctor’s consultation and wear UVA-absorbing wrap-around sunglasses following treatment with Pigolyn 0.2% Cream. 
  • Wear clothing that protects your skin from the sun. 
  • Be careful before applying anything to your skin to treat dryness and itchiness caused by Pigolyn 0.2% Cream.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Pigolyn 0.2% Cream during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CAUTION
Pigolyn 0.2% Cream should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.
Driving

Driving

No interaction found/established
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established

Frequently asked questions

Pigolyn 0.2% Cream is mainly used in the treatment of vitiligo, which causes white patches on the skin, and psoriasis, a condition characterized by thickened or scaly skin.
Pigolyn 0.2% Cream makes the skin more sensitive to ultraviolet (UV) light. When combined with controlled UV therapy (PUVA), it activates pigment-producing cells and promotes the regaining of normal skin color in vitiligo or slows excess skin cell growth in psoriasis.
Individuals should not use Pigolyn 0.2% Cream if they are allergic to psoralens or any other ingredient present in it, or if they have a history of skin cancer, lupus, or other photosensitive conditions. Always check with your doctor before starting treatment.
Yes, Pigolyn 0.2% Cream can cause severe skin redness, swelling, painful blisters, skin peeling, allergic reactions, or excessive sun sensitivity. If you experience any of these, stop treatment and seek medical help.
Long-term use of name Pigolyn 0.2% Cream combined with excessive UV exposure may increase the risk of premature skin aging or skin cancer. Regular doctor checkups during treatment are important.
No, you must avoid natural sunlight after Pigolyn 0.2% Cream application without protective clothing or sunscreen, as it dramatically increases the risk of sunburn and skin damage.

Fact Box

Chemical Class

Furocoumarins

Habit Forming

No

Therapeutic Class

DERMA

Action Class

Psoralen & derivatives

References

  1. Robertson DB, Maibach HI. Dermatologic Pharmacology. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 1055.
  2. PubChem. Trioxasalen. [Accessed 03 Apr. 2019] (online) Available from:
  3. Trioxasalen. Karnal, Haryana: CANBRO Healthcare; [Accessed 21 Apr. 2026] (online). Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Praise Pharma
Address: BLOCK NO:1, PAUL WAREHOUSE,S.NO:222/6, DHANGAR WASTI, MAHATMA PHULE NAGAR, URULI DEVACHI, TAL.HAVELI, DIST. PUNE, MAHARASHTRA, INDIA. 412308

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Pigolyn 0.2% Cream. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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