TPMT and NUDT15 Gene Analysis

TPMT (thiopurine S-methyltransferase) and NUDT15 (nudix hydrolase 15) gene analysis is an important test that helps doctors personalize treatment, especially for patients taking thiopurine medications. Thiopurines are strong drugs used to treat conditions like leukemia and inflammatory bowel disease (IBD), but they can sometimes cause serious side effects, such as neutropenia (decreased white blood cells).

These genes control enzymes that break down thiopurines in the body. Changes (variants) in these genes can affect how well your body processes the drugs. This test checks for such changes to identify people who may be at higher risk of side effects from standard doses. Knowing your TPMT and NUDT15 status helps doctors adjust the medication dose to make treatment safer and more effective.

Doctors may recommend the TPMT and NUDT15 Gene Analysis for patients starting thiopurine medications, such as mercaptopurine, azathioprine, or thioguanine, especially if they have a history of severe reactions, a family history of drug sensitivity, or conditions like leukemia, autoimmune disorders, or inflammatory bowel disease (IBD). Accurate testing of TPMT and NUDT15 helps doctors tailor treatment, prevent serious side effects like bone marrow suppression, liver problems, or flu-like symptoms, and ensure safe and effective therapy.

For this test, it is important to submit the clinical history, histopathology report, previous test results, and a doctor’s prescription at the time of sample collection. The Tata 1mg consolidated Test Requisition Form (TRF) must also be duly filled and submitted.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results.

Note: Genetic counseling can be provided. If interested, please send the request to this email id:[email protected]