
Total Leukocyte Count









The Total Leukocyte Count, also known as TLC test measures the number of leukocytes, also known as white blood cells (WBCs), in the blood. This test helps detect infection, inflammation, and bone marrow disorders. It is often done as part of a complete blood count test that also measures other types of blood cells.













Understanding Total Leukocyte Count
Leukocytes or WBCs are white-colored blood cells that are a part of the immune system and defend the body against infections and diseases. There are five types of WBCs, namely basophils, eosinophils, lymphocytes, monocytes, and neutrophils, and each one supports the immune system differently.
A decrease in the TLC count is referred to as leukopenia and indicates a decline in the body’s ability to fight infections. Whereas, an increase in TLC, known as leukocytosis, indicates acute infections and inflammation. Your doctor may advise the Total Leukocyte Count test if you show symptoms suggestive of an infection, inflammation, or other health conditions like bone marrow disorders. However, this test is followed up with other tests to determine the exact cause of the abnormal results. A TLC test is also used to monitor your response to medical treatments that can affect the immune system, including chemotherapy which is known to affect the number of leukocytes. No special preparation is needed for a TLC test; eat or drink normally as per your daily routine.
Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. The test results will help your doctor determine your medical condition, make recommendations for lifestyle modifications such as diet and exercise, decide whether or not medication will be required to manage your condition and formulate your overall treatment plan.
What does Total Leukocyte Count measure?
The Total Leukocyte Count test measures the numbers of all types of leukocytes, namely neutrophil, lymphocyte, monocyte, eosinophil, and basophil, in your blood. Leukocytes or WBCs are an essential part of our immune system. These cells are produced in the bone marrow and defend the body against infections and diseases. Each type of WBC plays a unique role to protect against infections and is present in different numbers.















FAQs related to Total Leukocyte Count
- Dale D. Overview of White Blood Cell Disorders [Internet]. NJ, USA: MSD Manual; Apr. 2023 [Accessed 06 May 2023]. Available from:
- What Are White Blood Cells? [Interent]. Rochester, NY: University of Rochester Medical Center; [Accessed 06 May 2023]. Available from:
- Shafi SM, Afsheen M, Reshi FA. Total leucocyte count, C-reactive protein and neutrophil count: diagnostic aid in acute appendicitis. Saudi J Gastroenterol. 2009 Apr;15(2):117-20. [Accessed 06 May 2023]. Available from:
- Corre F, Lellouch J, Schwartz D. Smoking and leucocyte-counts. The Lancet. 1971;298(7725):632-634. [Accessed 06 May 2023]. Available from:
- England JM, Bain BJ. Total and differential leucocyte count. Br J Haematol. 1976 May;33(1):1-7. [Accessed 06 May 2023]. Available from:
- A T Raftery, The value of the leucocyte count in the diagnosis of acute appendicitis, British Journal of Surgery, 1976 Feb;63(2):143–144. [Accessed 06 May 2023]. Available from:
Other tests
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)





















