ROS-1 by FISH

ROS-1 by FISH is a test used to detect genetic changes (mutations) in the ROS-1 (Repressor of Silencing 1) gene which is responsible for cell growth and development. The ROS1 gene located on chromosome 6 has the potential to undergo fusion or rearrangement, leading to the development of uncontrolled cell growth and the onset of non-small cell lung cancer (NSCLC), the most common form of lung cancer. A FISH technique is used to screen for these fusions. Gene fusions involving ROS1 are present in 1-2% of non-small cell lung carcinoma (NSCLC). Patients with ROS1-fusion-positive tumors have shown good responses to Kinase inhibitors or Crizotinib therapy.

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