PNH Advance

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₹6175

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The PNH Advance test is a specialized blood test used to detect and confirm Paroxysmal Nocturnal Hemoglobinuria (PNH), a rare, acquired blood disorder. It works by identifying blood cells that lack protective surface proteins, making them more likely to break down (hemolyze). This test helps doctors diagnose PNH, assess its severity, and monitor the response to treatment.

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Core Diagnostics Private Limited

ISO, CAP, NABL certified

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Core Diagnostics Private Limited

ISO, CAP, NABL certified

About this lab

We at CORE Diagnostics are a renowned pathology testing laboratory & a premier institute in the country capable of providing varied diagnostic tests & facilities in the field of laboratory medicine and have established state-of-art testing facilities in Gurgaon. We are a Clinical laboratory focused on Next Generation Diagnostics for disease stratification and therapy selection. We are focused on bringing the most advanced testing techniques and expertise to India and aim to become the destination for all your high-end diagnostic needs.

Understanding PNH Advance

Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare and acquired blood disorder that causes premature destruction of red blood cells (hemolysis). It occurs due to a mutation in the PIGA gene, which results in the absence of protective GPI (glycosylphosphatidylinositol)-anchored proteins on the surface of blood cells. Without these proteins, blood cells become vulnerable to attack by the immune system.

The PNH Advance is a specialized flow cytometry-based blood test used to detect and confirm the presence of PNH. This advanced technique analyzes blood cells to identify those lacking the protective proteins CD55 and CD59 on their surface. Measuring the absence or deficiency of these proteins helps doctors determine the PNH clone size (the proportion of affected cells), assess disease severity, and monitor response to treatment.

Doctors usually recommend this test for individuals with unexplained anemia, dark urine, frequent blood clots, or bone marrow failure disorders such as aplastic anemia or myelodysplastic syndromes (MDS), where PNH may coexist. Early detection plays a key role in guiding appropriate treatment and improving long-term outcomes, as untreated PNH can be life-threatening.

For this test, it is important to submit the clinical history, histopathology report, previous test results, and a doctor’s prescription at the time of sample collection. The Tata 1mg consolidated Test Requisition Form (TRF) must also be duly filled and submitted.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results.

What does PNH Advance measure?

The PNH Advance measures the presence and proportion of blood cells that lack certain protective surface proteins, specifically CD55 and CD59. These proteins normally help safeguard red blood cells from being destroyed by the immune system’s complement pathway.

Using flow cytometry, a highly sensitive laboratory technique, this test can detect even a small number of defective cells and determine the PNH clone size, which indicates the percentage of blood cells affected by the condition. A larger clone size often suggests a more severe form of the disease and helps doctors evaluate disease progression, monitor response to treatment, and assess prognosis.

In some cases, the test also analyzes various types of blood cells, such as red blood cells, white blood cells, and platelets, to provide a more detailed assessment of how extensively PNH affects the blood system.

Test Information is reviewed by: Dr. Swati Gupta (Anand), MD Lab Medicine, MBBS and written by Shweta Prakash, MSc, BSc . The test details are for information purpose only. Consult a doctor before taking any test. Last updated on: 15th Apr 2026

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PNH Advance test price for other cities

Price in	Ahmedabad	Rs. 6175
Price in	Allahabad	Rs. 6175
Price in	Asansol	Rs. 6175
Price in	Bangalore	Rs. 6175
Price in	Bhopal	Rs. 6175

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FAQs related to PNH Advance

Why is the PNH Advance test done?

This test is performed to confirm a diagnosis of PNH, measure the proportion of affected blood cells (PNH clone size), and monitor disease progression or treatment response. It is often recommended for individuals with unexplained anemia, hemolysis, or bone marrow disorders such as aplastic anemia or myelodysplastic syndromes (MDS).

What information does this test provide?

The PNH Advance test detects blood cells lacking the protective proteins CD55 and CD59. It helps identify the presence of PNH, measure the proportion of affected blood cells (known as the PNH clone size), assess disease severity, and monitor response to treatment.

How is the PNH Advance test performed?

A phlebotomist will clean your skin using an antiseptic alcohol cotton swab or wipe and take blood samples from your vein using a needle. The blood sample will be stored safely and transported to the laboratory for analysis.

Do I need to fast before taking the PNH Advance test?

No fasting is required for this test. You can schedule it at your convenience without avoiding food or water beforehand.

Is there any risk associated with the PNH Advance test?

No, the PNH Advance test is generally safe with minimal risks. However, you may feel slight discomfort during blood sample collection, but the chances of serious complications are extremely rare.

How often should this test be done?

This test is usually done when PNH is suspected based on symptoms or other lab results. The need for repeat testing depends on the patient’s condition and the doctor’s advice.

What do the test results indicate?

If a significant percentage of blood cells lack CD55 and CD59, it confirms the presence of PNH. The higher the proportion of affected cells (clone size), the more severe the disease and its symptoms are likely to be.

What is Paroxysmal Nocturnal Hemoglobinuria (PNH)?

PNH is a rare blood disorder where red blood cells break down (hemolysis) earlier than normal. This happens because of a genetic change in bone marrow stem cells that makes blood cells more sensitive to the body’s immune system.

Why is it called “nocturnal” hemoglobinuria?

The term “nocturnal” means “at night.” In some people with PNH, red blood cell breakdown happens more during sleep, leading to dark-colored urine in the morning due to released hemoglobin.

What causes PNH?

PNH is caused by an acquired mutation in the PIGA gene, which affects the production of protective proteins on blood cell surfaces. Without these proteins, blood cells become vulnerable to destruction by the immune system.