
PNH Advance near me in Asansol







The PNH Advance test is a specialized blood test used to detect and confirm Paroxysmal Nocturnal Hemoglobinuria (PNH), a rare, acquired blood disorder. It works by identifying blood cells that lack protective surface proteins, making them more likely to break down (hemolyze). This test helps doctors diagnose PNH, assess its severity, and monitor the response to treatment. This test is widely available with Tata 1mg labs at an affordable price in Asansol.








What does PNH Advance measure?
The PNH Advance measures the presence and proportion of blood cells that lack certain protective surface proteins, specifically CD55 and CD59. These proteins normally help safeguard red blood cells from being destroyed by the immune system’s complement pathway.
Using flow cytometry, a highly sensitive laboratory technique, this test can detect even a small number of defective cells and determine the PNH clone size, which indicates the percentage of blood cells affected by the condition. A larger clone size often suggests a more severe form of the disease and helps doctors evaluate disease progression, monitor response to treatment, and assess prognosis.
In some cases, the test also analyzes various types of blood cells, such as red blood cells, white blood cells, and platelets, to provide a more detailed assessment of how extensively PNH affects the blood system.





- Brando B, Gatti A, Preijers F. Flow Cytometric Diagnosis of Paroxysmal Nocturnal Hemoglobinuria: Pearls and Pitfalls - A Critical Review Article. EJIFCC. 2019 Nov 25;30(4):355-370. PMID: 31814811; PMCID: PMC6893893. [Accesses 06 Nov. 2025]. Available From:
- Mishra P, Tripathi P, Halder R, Saxena R, Tyagi S, Mahapatra M, Pati HP. Clinico-Hematological Profile of Paroxysmal Nocturnal Hemoglobinuria in Indian Patients: FLAER Flow Cytometry Based Experience from an Indian Tertiary Care Centre. Indian J Hematol Blood Transfus. 2021 Apr;37(2):220-225. [Accesses 06 Nov. 2025]. Available From:
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