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Dr. Shreya Gupta
BDS, MDS - Oral and Maxillofacial Pathology
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MBBS, MD (Pharmacology)
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NAFLD (Non Alcoholic Fatty Liver Disease) Fibrosis Score

NAFLD (Non Alcoholic Fatty Liver Disease) Fibrosis Score Includes 5 testsView All
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Understanding NAFLD (Non Alcoholic Fatty Liver Disease) Fibrosis Score

What is NAFLD (Non Alcoholic Fatty Liver Disease) Fibrosis Score?

NAFLD fibrosis score is the most studied score which has been extensively validated in a large population of patients with Non Alcoholic Fatty Liver disease (NAFLD) for detecting significant fibrosis.. NAFLD is the most common cause of abnormal liver function tests in primary care. It is associated with obesity, insulin resistance, diabetes etc

What does NAFLD (Non Alcoholic Fatty Liver Disease) Fibrosis Score measure?

Contains 5 tests

Fibrosis Score

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An SGOT test measures the levels of serum glutamic-oxaloacetic transaminase (SGOT), also known as aspartate aminotransferase (AST), an enzyme produced by the liver. SGOT is present in most body cells, most abundantly in the liver and heart. The primary function of this enzyme is to convert food into glycogen (a form of glucose), which is stored in the cells, primarily the liver. The body uses this glycogen to generate energy for various body functions.

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Platelet Count

A Platelet Count test measures the average number of platelets in the blood. Platelets are disk-shaped tiny cells originating from large cells known as megakaryocytes, which are found in the bone marrow. After the platelets are formed, they are released into the blood circulation. Their average life span is 7-10 days. 

Platelets help stop the bleeding, whenever there is an injury or trauma to a tissue or blood vessel, by adhering and accumulating at the injury site and releasing chemical compounds that stimulate the gathering of more platelets. A loose platelet plug is formed at the site of injury and this process is known as primary hemostasis. These activated platelets support the coagulation pathway that involves a series of steps, including the sequential activation of clotting factors; this process is known as secondary hemostasis. After this step, there is a formation of fibrin strands that form a mesh incorporated into and around the platelet plug. This mesh strengthens and stabilizes the blood clot so that it remains in place until the injury heals. After healing, other factors come into play and break the clot down so that it gets removed. In case the platelets are not sufficient in number or not functioning properly, a stable clot might not form. These unstable clots can result in an increased risk of excessive bleeding. 

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An SGPT test measures the amount of ALT or SGPT enzyme in your blood. ALT is most abundantly found in the liver, but it is also present in smaller amounts in other organs like the kidneys, heart, and muscles. Its primary function is to convert food into energy. It also speeds up chemical reactions in the body. These chemical reactions include the production of bile and substances that help your blood clot, break down food and toxins, and fight off an infection.

Elevated levels of ALT in the blood may indicate liver damage or injury. When the liver cells are damaged, they release ALT into the bloodstream, causing an increase in ALT levels. Therefore, the SGPT/ALT test is primarily used to assess the health of the liver and to detect liver-related problems such as hepatitis, fatty liver disease, cirrhosis, or other liver disorders.

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Serum Albumin

A Serum Albumin test measures the level of albumin protein in your blood. Albumin is one of the major proteins found in your body; about 60% of the total protein is made up of albumin, which is produced by the liver. It helps carry small molecules, such as hormones, vitamins, minerals, and medicines, throughout the body. It also serves as a source of amino acids for tissue metabolism. Albumin helps stop the fluid from leaking out of the blood vessels. When the albumin level is insufficient, the fluid can leak out of your blood vessels and build up in your lungs, belly, or other body parts.

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