The MPN Panel detects genetic mutations and gene fusions that are important in diagnosing and classifying myeloproliferative neoplasms (MPNs). The test is divided into the following categories:
Hotspot Genes: These genes are frequently mutated in MPNs and related blood disorders, and their analysis helps identify abnormal blood cell production:-
ABL1, CBL, FLT3, IDH1, IDH2, JAK2, KIT, MPL, NPM1, NRAS, SF3B1, SRSF2, U2AF1, DNMT3A
Full Genes: These genes are fully sequenced to detect a broader range of mutations, which can aid in disease classification, prognosis, and monitoring:
ASXL1, CALR, EZH2, IKZF1, NF1, RUNX1, SH2B3, STAG2, TET2, TP53, ZRSR2
Gene Fusions: Certain gene rearrangements (fusions) are analyzed because they can drive abnormal blood cell growth and impact disease behavior:-
ETV6, JAK2, KMT2A, RUNX1
By examining these hotspot genes, full genes, and gene fusions, the test provides a comprehensive molecular profile, helping doctors accurately diagnose, classify, and manage MPNs.
Hotspot genes: ABL1, CBL, FLT3, IDH1, IDH2, JAK2, KIT, MPL, NPM1, NRAS,SF3B1, SRSF2, U2AF1,DNMT3A
Full genes: ASXL1, CALR, EZH2, IKZF1, NF1, RUNX1, SH2B3, STAG2, TET2, TP53, ZRSR2