Liver Kidney Microsome - 1 Antibody near me in Chennai
Understanding Liver Kidney Microsome - 1 Antibody in Chennai
What is Liver Kidney Microsome - 1 Antibody in Chennai?
The Liver Kidney Microsome - 1 Antibody test is a blood test used to detect the presence of antibodies directed against liver and kidney microsomal antigens (produced in various liver conditions). This test helps diagnose autoimmune liver diseases, particularly type 2 autoimmune hepatitis (AIH-2), distinguishing it from other liver conditions such as type 1 autoimmune hepatitis (AIH-1), viral hepatitis, drug-induced liver injury, and other liver disorders. This test is widely available with Tata 1mg labs in Chennai at an affordable price.
The test can be done if symptoms of liver disease such as jaundice (yellowing of the skin and eyes), unexplained fatigue, abdominal pain, dark urine, pale stools etc, and abnormal liver function tests (particularly alanine aminotransferase (ALT), and aspartate aminotransferase (AST)) are noticed. This test can also be used to monitor the progression of type 2 AIH and the response to treatment.
What does Liver Kidney Microsome - 1 Antibody measure?
The Liver Kidney Microsome - 1 Antibody test detects the presence of specific antibodies called liver kidney microsome-1 (LKM-1) antibodies. LKM-1 antibodies are specialized proteins produced by the body’s immune system that mistakenly target and attack a liver enzyme called cytochrome P450 2D6 (CYP2D6). These antibodies are strongly linked with type 2 autoimmune hepatitis (AIH), making it a highly specific marker for the disease. Type 2 AIH primarily affects children and young adults, unlike type 1 AIH, which is more common in adults. It can lead to inflammation and damage to liver cells, potentially progressing to cirrhosis if untreated. Additionally, determining the presence of LMK-1 antibodies over time can help assess the effectiveness of treatment and adjust therapeutic strategies if needed. The Liver Kidney Microsome - 1 Antibody test thus plays a crucial role in the management of AIH-2, guiding both the initial diagnosis and ongoing treatment decisions.
Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Liver Kidney Microsome - 1 Antibody in Chennai
Frequently Asked Questions about Liver Kidney Microsome - 1 Antibody in Chennai
Q. Why is the Liver Kidney Microsome - 1 Antibody test important?
Q. When the Liver Kidney Microsome - 1 Antibody test is done?
Q. How often should I take the Liver Kidney Microsome - 1 Antibody test?
Q. What is the difference between LKM-1 antibodies and other autoimmune hepatitis markers?
Q. Can the LKM-1 antibody test differentiate between acute and chronic liver conditions?
Q. Can I schedule the Liver Kidney Microsome - 1 Antibody test online in Chennai near me?
Q. Is home sample collection facility available for the Liver Kidney Microsome - 1 Antibody test in Chennai with Tata 1mg Labs?
Q. How can I schedule the Liver Kidney Microsome - 1 Antibody test with Tata 1mg Labs in Chennai?
Q. What is the price of the Liver Kidney Microsome - 1 Antibody test at Tata 1mg Labs in Chennai?
Q. What is the estimated turnaround time for the results of the {test-name} test in Chennai?
Book a Liver Kidney Microsome - 1 Antibody test at home near me
References
- Liver Kidney Microsomal Antibody [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 27 May 2024]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=liver_kidney_microsomal_antibody
- Autoimmune Hepatitis [Internet]. USA: NIDDK; Apr.2023 Accessed 27 May 2024]. Available from: https://www.niddk.nih.gov/health-information/liver-disease/autoimmune-hepatitis
- Kerkar N, Ma Y, Davies ET, Cheeseman P, Mieli-Vergani G, Vergani D. Detection of liver kidney microsomal type 1 antibody using molecularly based immunoassays. J Clin Pathol. 2002 Dec;55(12):906-9. Accessed 27 May 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769836/
- Muratori L, Cataleta M, Muratori P, Lenzi M, Bianchi FB. Liver/kidney microsomal antibody type 1 and liver cytosol antibody type 1 concentrations in type 2 autoimmune hepatitis. Gut. 1998 May;42(5):721-6. Accessed 27 May 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1727121/
- Linzay CD, Sharma B, Pandit S. Autoimmune Hepatitis. [Updated 2023 Aug 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: Accessed 27 May 2024]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459186/
- Lapierre P, Alvarez F. Type 2 autoimmune hepatitis: Genetic susceptibility. Front Immunol. 2022 Sep 29;13:1025343. Accessed 27 May 2024]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556705/
- Komurasaki R, Imaoka S, Tada N, Okada K, Nishiguchi S, Funae Y. LKM-1 sera from autoimmune hepatitis patients that recognize ERp57, carboxylesterase 1 and CYP2D6. Drug Metab Pharmacokinet. 2010;25(1):84-92. Accessed 27 May 2024]. Available from: https://pubmed.ncbi.nlm.nih.gov/20208391/
Other tests
