
Leptospira - IgG antibody








The Leptospira - IgG antibody test is a blood test that helps diagnose leptospirosis, a bacterial infection commonly spread through contact with the urine of infected animals or contaminated water and soil. This test measures IgG antibodies against Leptospira bacteria and helps assess past exposure or late-stage infection.













Understanding Leptospira - IgG antibody
Leptospirosis is a bacterial disease caused by Leptospira bacteria. These bacteria are spiral in shape, which is reflected in their name. In humans, this disease spreads through direct or indirect contact with urine of infected animals in contaminated water or soil.
The Leptospira - IgG antibody test helps identify IgG antibodies, typically produced by the immune system during the later stages of leptospirosis infection or after an individual has recovered from the infection. Unlike IgM antibodies, which appear early, IgG antibodies indicate previous or prolonged exposure and may remain detectable for months or years.
Leptospirosis causes symptoms like high grade fever, sudden headache, nausea/vomiting, loss of appetite, and muscle pain. These flu-like symptoms often lead to misdiagnosis as dengue, hepatitis, or regular flu. The Leptospira - IgG antibody test is vital for retrospective diagnosis of leptospirosis and also helps in follow-up infection cases where IgM antibodies may have declined.
No special preparation is required for the Leptospira - IgG antibody test. However, clinical history and details of relevant exposure like travel or floodwater contact should be narrated to a doctor to help them correlate laboratory and clinical findings. Also, inform the doctor about all the medications, supplements or underlying illnesses that you may have as all these factors can affect the test results.
Laboratory test results may vary across laboratories. Do not self-medicate and always consult a doctor to understand the test results correctly. In some cases, repeat testing or additional confirmatory tests may be warranted.
Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.
What does Leptospira - IgG antibody measure?
The Leptospira - IgG antibody test measures the levels of IgG antibodies in the blood that are produced by the body in response to Leptospira infection.
A positive test result may signal a past or previous infection, prolonged disease or immunity. A negative result may either mean absence of infection or testing too early before antibodies are detectable (when IgG antibodies have not yet developed). For acute cases, follow-up testing or an IgM antibody test may be warranted.





FAQs related to Leptospira - IgG antibody
- Doungchawee G, Kositanont U, Niwetpathomwat A, Inwisai T, Sagarasaeranee P, Haake DA. Early diagnosis of leptospirosis by immunoglobulin M immunoblot testing. Clin Vaccine Immunol. 2008 Mar;15(3):492-8. [Accessed 16 Jul 2025]. Available From:
- Budihal SV, Perwez K. Leptospirosis diagnosis: competancy of various laboratory tests. J Clin Diagn Res. 2014 Jan;8(1):199-202. [Accessed 16 Jul. 2025]. Available From:
- About Leptospirosis [Internet]. CDC; 08 Aug. 2025 [Accessed 16 Jul. 2025] Available from:
- Sahimin N, Sharif SA, Mohd Hanapi IR, Nai Chuan S, Lewis JW, Douadi B, Mohd Zain SN. Seroprevalence of Anti-Leptospira IgG and IgM Antibodies and Risk Assessment of Leptospirosis among Urban Poor Communities in Kuala Lumpur, Malaysia. Am J Trop Med Hyg. 2019 Dec;101(6):1265-1271. [Accessed 16 Jul. 2025] Available from:
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