JC/BK Quantitative PCR

Also referred as

JC-BK Virus DNA Detection by RT-PCR

EDTA Blood

For men & women

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96 hours

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Test price:

₹9270

~~₹10300~~

10% off

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The JC/BK Quantitative PCR test is a blood test used to measure the levels of two polyomaviruses: JC (John Cunningham) and BK, in the blood. These viruses are common and usually stay dormant in healthy people but can become active in those with weakened immune systems, especially organ transplant or kidney surgery patients. Early detection helps doctors monitor viral activity and manage complications effectively.

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MedGenome Labs Limited

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MedGenome Labs Limited

ISO, CAP, NABL certified

About this lab

MedGenome is a Global Leader in Genetic Testing services, Genomics Research and drug discovery solutions. MedGenome is trusted by 10,000+ clinicians, recommended by 4,000+ hospitals, and offers 1,300+ genetic tests. MedGenome has been committed to deliver world class genomic solutions with greater precision and accuracy to empower every human being for better management of their health since 2013. MedGenome is the only CAP accredited Genetic testing lab in India that offers 1300+ genetic tests backed by the best and the latest testing technologies available across the world. MedGenome is dedicated to bringing the best precision testing solutions for quicker and smarter diagnosis of complex diseases.

Understanding JC/BK Quantitative PCR

The JC/BK Quantitative PCR test is used to detect and quantify the amount of viral DNA (viral load) of JC and BK viruses. These two viruses belong to the polyomavirus family. Both viruses are commonly acquired in childhood and remain dormant in the body. BK virus in the kidneys and JC virus in various tissues, without causing illness in healthy individuals.

However, in people with weakened immunity, such as kidney or bone marrow transplant recipients, or those with conditions like HIV/AIDS or diabetes, these viruses can reactivate and cause serious complications.

BK virus reactivation may lead to polyomavirus-associated nephropathy (PVAN), ureteral problems, or hemorrhagic cystitis.
JC virus reactivation can affect the brain, causing progressive multifocal leukoencephalopathy (PML), a severe neurological disorder.

Since there are no specific antiviral drugs for these infections, this test plays a key role in monitoring viral load and guiding timely treatment decisions. Regular monitoring helps doctors adjust immunosuppressive therapy to control viral spread, protect kidney function, and prevent rejection reactions after transplantation.

Doctors may recommend the JC/BK Quantitative PCR test when there are unexplained changes in kidney function, neurological symptoms, or when a patient is at risk of viral reactivation due to a weakened immune system. It is commonly advised for transplant recipients or those on immunosuppressive therapy to monitor for early signs of infection. The test helps track viral levels in the blood, guiding doctors in adjusting treatment or medications to prevent complications and ensure better recovery outcomes.

For this test, a MedGenome Micra TRF form must be filled out. It is important to provide a detailed clinical history and current drug regimen along with the form for accurate interpretation and reporting.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for a proper understanding of the test results.

What does JC/BK Quantitative PCR measure?

The JC/BK Quantitative PCR test measures the presence and amount of JC virus (JCV) and BK virus (BKV) DNA in the blood using Real-Time Polymerase Chain Reaction (RT-PCR) technology. This method amplifies even very small amounts of viral genetic material, making it highly sensitive and accurate for early detection. High levels of JC viral DNA may indicate an active infection and are associated with an increased risk of Progressive Multifocal Leukoencephalopathy (PML), a serious neurological condition. Similarly, elevated BK viral DNA levels suggest active infection, which can lead to complications such as BK virus-associated nephropathy (BKVAN) or urinary tract issues, particularly in transplant recipients. Low or undetectable levels of either virus generally indicate that the infection is inactive or well-controlled. By quantifying viral load, this test enables regular monitoring, helps detect early reactivation, guides treatment decisions, allows adjustment of immunosuppressive therapy, and aids in preventing serious complications.

Test Information is reviewed by: Dr. Swati Gupta (Anand), MD Lab Medicine, MBBS and written by Shweta Prakash, MSc, BSc . The test details are for information purpose only. Consult a doctor before taking any test. Last updated on: 13th Aug 2026

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JC/BK Quantitative PCR test price for other cities

Price in	Agra	Rs. 9270
Price in	Ahmedabad	Rs. 9270
Price in	Allahabad	Rs. 9270
Price in	Bangalore	Rs. 9270
Price in	Bhopal	Rs. 9270

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FAQs related to JC/BK Quantitative PCR

What is the JC/BK Quantitative PCR test?

The JC/BK Quantitative PCR test is a blood test that measures the viral load of JC virus (JCV) and BK virus (BKV) using Real-Time PCR technology. It helps determine whether these viruses are active and is useful for monitoring patients at risk of complications.

Why is this test important for transplant patients?

In transplant patients, these viruses can reactivate due to weakened immunity. The BK virus may damage transplanted kidneys (BK virus nephropathy), while the JC virus can cause serious neurological conditions like Progressive Multifocal Leukoencephalopathy (PML). Early detection with this test helps doctors intervene promptly and protect organ function.

Who should get this test done?

This test can be done when there is a case of kidney or bone marrow transplant recipients, people on long-term immunosuppressive therapy, or those with symptoms like unexplained kidney dysfunction, urinary problems, or blood in urine.

Do I need to fast before this test?

No, fasting is not required.

How is the test performed?

A small sample of blood is collected and analyzed using RT PCR technology to detect JC and BK viral DNA.

Are there any risks associated with the test?

The test involves only a blood draw, which is generally safe. Minor discomfort, bruising, or swelling at the site of needle insertion may occur. Serious complications are very rare.

What do high or low results mean?

High viral load indicates active infection, requiring close monitoring and potential adjustment of immunosuppressive therapy. On the other hand, a low or undetectable viral load suggests the virus is inactive or well-controlled.

What are the risks if the viruses are not detected early?

If left undetected, the BK virus may cause nephropathy, transplant rejection, hemorrhagic cystitis, or urinary tract issues. JC virus may cause neurological complications like PML, which can be life-threatening.

What are JC and BK viruses?

JC virus (JCV) and BK virus (BKV) are common human polyomaviruses. Most people are exposed to them in childhood, and the viruses remain dormant in the body without causing symptoms in healthy individuals.

Why do these viruses reactivate?

Reactivation usually happens in people with weakened immune systems, such as those on immunosuppressive drugs after organ transplantation, people with HIV/AIDS, or patients undergoing chemotherapy.

Can healthy people have JC or BK viruses?

Yes. Most people acquire these viruses in childhood. They usually remain dormant and cause no health problems in healthy individuals but may reactivate if the immune system becomes weak.

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