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IGLON5 Antibody, Serum

Also referred as

IgLON5 test

Antibody for encephalitis

For men & women

Earliest reports in

168-192 hours

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1 test

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The IGLON5 Antibody, Serum test is a blood test that helps diagnose IgLON5 disease, a rare autoimmune neurological disorder that may cause sleep problems, poor balance, and speech or swallowing issues. This test helps detect immunoglobulin G (IgG) antibodies against the IgLON5 protein.d patients with sleep disorders and gait dysfunctions. The presence of IgLON5 Antibodies may indicate autoimmune encephalitis, Creutzfeldt-Jakob disease, or rapidly progressive neurodegenerative dementia.

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Blood

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Preparations

No special preparation is required.

Sample Collection

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Understanding IGLON5 Antibody, Serum

The IGLON5 Antibody, Serum test checks for IgG antibodies that help confirm IgLON5 disease, an uncommon autoimmune neurological disease. It is a multifactorial disease caused by autoimmune and neurodegenerative processes. It occurs when the immune system mistakenly produces antibodies against the IgLON5 protein, which is normally found in the brain. These antibodies attack nerve cells that control movements, bodily functions, and sleep. As a result, individuals can experience sleep disturbances, trouble walking, speaking, or swallowing, and sometimes memory issues.

A doctor may advise the IGLON5 Antibody, Serum test when an individual shows symptoms consistent with autoimmune encephalitis, or other neurodegenerative symptoms such as seizures, hallucinations, tremors, stiffness, or abnormal jerking, and may have previously undergone neuroimaging tests and other baseline investigations.

No special preparation is required for the IGLON5 Antibody, Serum. However, inform a doctor about any medications (e.g., immunosuppressants, steroids, other immunomodulatory drugs) and supplements being taken, as these factors may affect the test results.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate, and always consult a doctor to understand the test results correctly.

Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.

What does IGLON5 Antibody, Serum measure?

The IGLON5 Antibody, Serum is a blood test that measures the levels of IgG antibodies against the IgLON5 protein. The presence of these antibodies indicates an autoimmune reaction against neuronal structures and is considered a significant marker for IgLON5 disease. A positive test result supports the diagnosis, while a negative result does not entirely rule out the disease, especially in early or seronegative cases.

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FAQs related to IGLON5 Antibody, Serum

What is the IGLON5 Antibody, Serum test?

The IGLON5 Antibody, Serum test detects autoantibodies against the IgLON5 protein. It is used to help diagnose IgLON5 disease, a rare autoimmune neurological disorder.

Do I need to fast before the IGLON5 Antibody, Serum test?

No, fasting is not required for this test.

How is the test done?

A blood sample is drawn from a vein in your arm. The sample is then analyzed in a laboratory to detect the presence of IgG antibodies against IgLON5 protein.

Is there any risk associated with the test?

No, the IGLON5 Antibody, Serum test is generally safe with minimal risks. You may feel slight discomfort, bruising, or swelling at the blood draw site which resolves on its own and is not bothersome.

What do abnormal test results mean?

Positive result: Supports the diagnosis of IgLON5 disease, but needs further tests to confirm the diagnosis. Negative result: Makes the presence of IgLON5 disease less likely, but does not completely rule it out in cases with high clinical suspicion.

Can other conditions affect the test results?

Yes, concurrent autoimmune conditions or immunomodulatory medications can sometimes influence the antibody levels. Always inform your doctor about all the medications and underlying medical history when getting tested with the IGLON5 Antibody, Serum test.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

Content created by

Dr. Swati Gupta (Anand)

MBBS, MD Lab Medicine

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Last Updated

8th Jan 2026