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Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody)

Also known as Anti-TPO Ab Test, Thyroid peroxidase (TPO) antibody Test, Thyroid antibodies Test, Antithyroid Microsomal Antibody (AMA) Test
12491500 16% Off
You need to provide
Blood
This test is for
Male, Female
Test Preparation
  1. No special preparation is required.

Understanding Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody)


What is Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody)?

An Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) test helps detect the presence of antibodies against the enzyme thyroid peroxidase that is involved in producing thyroid hormones. This test helps diagnose and monitor autoimmune thyroid disorders, particularly Hashimoto's thyroiditis and Graves' disease. It may be done routinely or as part of a Thyroid Comprehensive Package, which also includes other thyroid function tests, to provide a holistic view of thyroid health. 

The thyroid gland is a small, butterfly-shaped organ in the neck region. This gland secretes an enzyme called thyroid peroxidase (TPO) that plays a vital role in producing other thyroid hormones. These thyroid hormones regulate metabolism, body temperature, and growth and development.

In the case of autoimmune thyroid disorders, such as Hashimoto's thyroiditis and Graves' disease, the body's immune system may produce antibodies against TPO, thus leading to inflammation and mistakenly damage to the normal tissue of  thyroid gland. An Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) test specifically detects these antibodies in the blood and provides insights into the underlying causes of thyroid dysfunction. Early detection of these antibodies can help predict the development of thyroid dysfunction and allow for timely intervention and management.

In Hashimoto's thyroiditis, a common cause of hypothyroidism (underactive thyroid), the immune system mistakenly recognizes TPO as a foreign invader, leading to chronic inflammation and damage to the thyroid tissue. Some symptoms suggestive of hypothyroidism include weight gain, fatigue, sensitivity to cold, constipation, and dry skin. 

In Graves' disease, a common cause of hyperthyroidism (overactive thyroid), the immune system produces antibodies that stimulate the thyroid gland to produce excess thyroid hormone. Some symptoms suggestive of hyperthyroidism include weight loss, nervousness, irritability, increased sweating, and rapid heartbeat.

No special preparations are needed for this test. Usually, you do not need to stop taking your thyroid medication before taking this test to maintain the test's accuracy. However, be sure to notify your doctor about any medications, herbs, and supplements (including over-the-counter medicines) that you are taking.

A positive result indicates the presence of anti-TPO antibodies in the blood, while a negative result implies the absence of detectable anti-TPO antibodies. However, further testing may be necessary as some individuals with autoimmune thyroid disorders may not have a detectable amount of anti-TPO antibodies.

Discuss your test results with the doctor. The test results will help them determine your medical condition, make recommendations for lifestyle modifications such as diet, exercise, and medication to manage your condition, and design your overall treatment plan.

What is Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) used for?

An Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) is done:

  • To assess your overall thyroid health and determine the underlying causes of thyroid dysfunction.

  • To diagnose autoimmune disorders of the thyroid like Hashimoto's thyroiditis (swelling of the thyroid gland resulting in decreased thyroid function), Grave's disease (overactive thyroid gland resulting in overproduction of thyroid hormones), or idiopathic myxedema (associated with low levels of thyroid hormones).

  • To differentiate autoimmune disorders of the thyroid from other causes of thyroid dysfunction, such as goiter.

  • To monitor the progression and treatment effectiveness of autoimmune thyroid disorders.

  • To assess the future risk of thyroid disorders.

What does Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) measure?

In autoimmune thyroid disorders, such as Hashimoto's thyroiditis and Graves’ disease, the immune system produces antibodies against thyroid peroxidase (TPO), an enzyme found in the thyroid gland. An Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) test detects and measures the levels of these anti-thyroid peroxidase (anti-TPO) antibodies in your blood.

TPO is found in the cells of the thyroid follicle and helps produce the thyroid hormones thyroxine (T4) or triiodothyronine (T3). The presence of anti-TPO antibodies indicates autoimmune activity against the thyroid gland. These antibodies contribute to inflammation and damage to thyroid cells, thus leading to thyroid dysfunction.

Interpreting Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) results


Interpretations

Positive tests may indicate the following:

  • Hashimoto’s thyroiditis
  • Grave’s disease
  • Idiopathic Myxedema
  • Postpartum thyroiditis
  • Nontoxic Nodular Goiter
  • Thyroid cancer





Answers to Patient Concerns & Frequently Asked Questions (FAQs) about Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody)


Frequently Asked Questions about Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody)

Q. What is an Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) test?

An Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) test is a diagnostic tool that measures antibodies against thyroid peroxidase, thus helping to identify autoimmune thyroid disorders.

Q. Why do I need an Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) test?

You may need an Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) test if you are suffering from the symptoms of hypothyroidism, such as weight gain, fatigue, sensitivity to cold, constipation, and dry skin, or those of hyperthyroidism, such as weight loss, nervousness, irritability, increased sweating, and rapid heartbeat. It is done to rule out autoimmune disease as the cause of your thyroid disorder. It also helps distinguish between autoimmune and non-autoimmune thyroid diseases, such as goiter (enlarged thyroid gland).

Q. What does a positive anti-TPO test result indicate?

A positive result suggests the presence of antibodies against thyroid peroxidase, indicating autoimmune activity in the thyroid and a potential risk of thyroid disorders.

Q. Can an Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) test predict future thyroid dysfunction?

Yes, elevated anti-TPO levels may serve as an early indicator that predicts an increased risk of developing thyroid dysfunction in the future.

Q. Is an anti-TPO test the only test for autoimmune thyroid disorders?

While the anti-TPO test is a primary marker, other tests, such as the anti-thyroglobulin antibodies test, may also be considered to assess autoimmune thyroid conditions comprehensively.

Q. Do TPO antibodies affect pregnancy?

The presence of TPO antibodies during pregnancy has been associated with increased rates of complications such as placental abruption, pregnancy-induced hypertension, preterm delivery, miscarriage, and postpartum thyroid disease, even if the thyroid function is normal.

Q. What is an autoimmune disorder?

An autoimmune disorder is when your body’s immune system starts to attack other parts of the body mistaking them for foreign bodies, such as joints or skin. Autoantibodies begin to release in the body, which attack the healthy cells.

Q. What are the risk factors for autoimmune disorders?

The risk factors for autoimmune disorders include a family history, obesity, smoking, taking blood pressure medications, cholesterol-lowering medications, and antibiotics.

Q. What additional tests can be performed if my anti-TPO test results are not in the normal range?

If your anti-TPO test results are not normal, your doctor may ask for thyroid-binding globulin (TBG) and thyroid profile tests.
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Anti-TPO Antibody(Anti-Thyroid Peroxidase Antibody) test price for other cities


Price inBangaloreRs. 1249
Price inGurgaonRs. 1249
Price inMumbaiRs. 1249
Price inKolkataRs. 1249
Price inHyderabadRs. 1249
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References

  1. Engler H, Riesen WF, Keller B. Anti-thyroid peroxidase (anti-TPO) antibodies in thyroid diseases, non-thyroidal illness and controls. Clinical validity of a new commercial method for detection of anti-TPO (thyroid microsomal) autoantibodies. Clin Chim Acta. 1994 Mar;225(2):123-36. [Accessed 26 Sep. 2023]. Available from: https://pubmed.ncbi.nlm.nih.gov/8088002/ External Link
  2. Tipu HN, Ahmed D, Bashir MM, Asif N. Significance of Testing Anti-Thyroid Autoantibodies in Patients with Deranged Thyroid Profile. J Thyroid Res. 2018 Apr 11;2018:9610497. [Accessed 26 Sep. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925209/ External Link
  3. Franco JS, Amaya-Amaya J, Anaya JM. Thyroid disease and autoimmune diseases. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18. Chapter 30. [Accessed 26 Sep. 2023]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459466/ External Link
  4. Meena M, Chopra S, Jain V, Aggarwal N. The Effect of Anti-Thyroid Peroxidase Antibodies on Pregnancy Outcomes in Euthyroid Women. J Clin Diagn Res. 2016 Sep;10(9):QC04-QC07. [Accessed 26 Sep. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5072023/ External Link
  5. Siriwardhane T, Krishna K, Ranganathan V, Jayaraman V, Wang T, Bei K, Ashman S, Rajasekaran K, Rajasekaran JJ, Krishnamurthy H. Significance of Anti-TPO as an Early Predictive Marker in Thyroid Disease. Autoimmune Dis. 2019 Jul 28;2019:1684074. [Accessed 26 Sep. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699358/ External Link
  6. Hashimoto’s Disease. Internet]. NIH; Jun. 2021. [Accessed 26 Sep. 2023]. Available from: https://www.niddk.nih.gov/health-information/endocrine-diseases/hashimotos-disease External Link
  7. Grave’s Disease. [Internet]. NIH; Nov. 2021. [Accessed 26 Sep. 2023]. Available from: https://www.niddk.nih.gov/health-information/endocrine-diseases/graves-disease External Link
  8. Thyroid Antibody [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 26 Sep. 2023]. Available from: https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=thyroid_antibody External Link
  9. Latif Z, Crupie MJ. Aberrant Thyroid Function Tests in a Patient Taking Biotin Supplements. Cureus. 2019 Aug 1;11(8):e5297. [Accessed 26 Sep. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768618/ External Link
  10. Odhaib SA, Mansour AA, Haddad NS. How Biotin Induces Misleading Results in Thyroid Bioassays: Case Series. Cureus. 2019 May 23;11(5):e4727. [Accessed 26 Sep. 2023]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663274/ External Link

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