
DPD/DPYD Mutation Analysis near me in Varanasi







The DPD/DPYD Mutation Analysis test detects mutations in the DPYD gene, which provides instructions for making the enzyme Dihydropyrimidine Dehydrogenase (DPD). This enzyme is essential for breaking down certain chemotherapy medicines like 5-Fluorouracil (5-FU) and Capecitabine. The test helps identify individuals who may have DPD deficiency, a condition that can cause severe or even life-threatening side effects when treated with standard doses of these medicines. Early detection allows doctors to adjust chemotherapy doses or choose alternative treatments for safer and more effective care. This test is widely available with Tata 1mg labs at an affordable price in Varanasi.








What does DPD/DPYD Mutation Analysis measure?
The DPD/DPYD Mutation Analysis test examines the DPYD gene for mutations that affect the production or function of the Dihydropyrimidine Dehydrogenase (DPD) enzyme.
This enzyme is crucial for metabolizing chemotherapy medicines like 5-Fluorouracil and Capecitabine. When DPD activity is reduced or absent, the body cannot properly break down these medicines, leading to an increased risk of severe toxicity.
Normal result indicates no significant mutation and normal DPD enzyme activity, standard chemotherapy dosing is generally safe. Abnormal results suggest reduced or absent DPD enzyme activity. Dosage adjustment or an alternate chemotherapy regimen may be recommended.
By identifying these mutations, the test helps doctors tailor chemotherapy safely, minimizing side effects and improving treatment outcomes.





- Patil VM, Noronha V, Joshi A, Zanwar S, Ramaswamy A, Arya S, Mahajan A, Bhattacharjee A, Prabhash K. Dihydropyrimidine dehydrogenase mutation in neoadjuvant chemotherapy in head and neck cancers: Myth or reality? South Asian J Cancer. 2016 Oct-Dec;5(4):182-185.
- Cancer Research UK. DPD deficiency [Internet]. London: Cancer Research UK; updated 11 July 2023; [Accessed 04 Nov 2025]. Available from:
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