DPD/DPYD Mutation Analysis near me in Varanasi

DPD, or Dihydropyrimidine Dehydrogenase, is an enzyme involved in the metabolism of fluoropyrimidines, a class of chemotherapy drugs that includes 5-fluorouracil (5-FU) and capecitabine. DPD plays a crucial role in breaking down these drugs in the body. DPD deficiency, which can be caused by genetic mutations in the DPYD gene (the gene that codes for the DPD enzyme), can lead to the accumulation of toxic levels of fluoropyrimidines in the body. This deficiency can result in severe and potentially life-threatening side effects when individuals are treated with standard doses of fluoropyrimidine-based chemotherapy.