Test Detail
Understanding the Test
Test Measures
Interpreting Results
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Home Collection
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Content created by
Written by
Dr. Betina Chandolia
BDS, MDS - Oral Pathology and Microbiology
Reviewed by
Dr. Ashish Ranjan
MBBS, MD (Pharmacology)
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Also known as Fragment D-dimer, Fibrin degradation fragment
You need to provide
This test is for
Male, Female
Test Preparation
  1. Overnight fasting is preferred.
  2. A duly filled coagulation requisition form (Annexure - CR/05) is mandatory for sample collection.
  3. Kindly provide complete clinical details and medication history or doctor's prescription; this information is important for correlation of your test results.

Understanding D-Dimer

What is D-Dimer?

A D-Dimer test looks for the presence of D-dimer, a protein fragment that forms when a blood clot dissolves in blood. This test determines D-dimer levels to detect conditions related to thrombosis (serious blood clot formation), such as deep vein thrombosis (DVT), pulmonary embolism (PE), and stroke.

D-dimer is a protein involved in the healing process of the body. When you get an injury that causes bleeding, your body uses proteins to clot the blood to stop the bleeding or to close the damaged vessel. Once the bleeding stops, the body sends out other proteins to slowly break down the clot. Afterward, the fragments of D-dimer remain inside your blood. These fragments usually dissolve over time. However, if a clot does not break or another one forms, you will have high levels of D-dimer in your blood. In a few cases, blood clots may sometimes form without a real injury. These are typical signs of a blood clotting disorder that can prove quite dangerous.

A D-Dimer test is used to diagnose or rule out the presence of blood clots, which can be a sign of serious conditions involving inappropriate clot formation. You may need this test when you have symptoms such as swelling, pain or redness in your legs, breathing trouble, coughing (may cough up blood), rapid heartbeat, chest pain, and sweating. Sometimes, this test is also used to monitor the effectiveness of treatment for these conditions. In addition, a D-dimer test also helps understand the risk and progression in cases of pneumonia and COVID-19.

Usually, overnight fasting (8-12 hours) is preferred for a D-Dimer test, and a duly filled coagulation requisition form is mandatory for sample collection. Before getting tested, also tell your doctor if you are taking any medications as they might interfere with the test results and the doctor may ask you to stop taking them for some time. 

Test result ranges are approximate and may differ slightly between different labs depending on the methodology and laboratory guidelines. Talk to your doctor about your specific test results to understand your condition and narrate your complete medical history to your doctor to help formulate an effective treatment plan.

What is D-Dimer used for?

A D-Dimer test is done:

  • To detect the presence of an inappropriate blood clot (thrombus).

  • If symptoms of deep vein thrombosis, such as pain, swelling, discolored skin of the legs with surfaced and enlarged veins, etc., are observed. 

  • If symptoms of pulmonary embolism, such as shortness of breath, coughing, back pain, pain in the chest, fast heart rate, and dizziness, are experienced.

  • If symptoms of disseminated intravascular coagulation, such as nausea, vomiting, seizures, bleeding gums, and muscular and abdominal pain, are observed. 

  • To rule out blood clotting caused by snake bite, thrombosis with thrombocytopenia syndrome (TTS), and stroke.

What does D-Dimer measure?

A D-Dimer test measures the amount of D-dimer protein that your body produces when you have an injury. D-dimer is released when a blood clot begins to break down. It is a byproduct of the blood clotting and clot break-down process that can be measured by analyzing a blood sample. D-dimer is normally undetectable in the blood and is produced only after a clot has formed and is in the process of being broken down.

Interpreting D-Dimer results


A “negative” D-dimer result (D-dimer levels below a predetermined value) means that the person being tested does not have an acute condition or disease-causing abnormal clot formation and breakdown in the body.

A "positive" D-dimer result may indicate that there may be a significant blood clot (thrombus) formation and breakdown in the body by detecting the presence of an abnormally high level of fibrin degradation products.



Answers to Patient Concerns & Frequently Asked Questions (FAQs) about D-Dimer

Frequently Asked Questions about D-Dimer

Q. What are the symptoms that may be associated with high D-dimer levels?

You may experience swelling, pain, warmth, and changes in the skin color of your leg or arm; sharp chest pain; trouble breathing; coughing up blood; or fast heartbeat when your D-dimer protein is high.

Q. What causes a rise in D-dimer level?

A clot anywhere in the body can cause elevated D-dimer levels. Usually, after an injury, once the bleeding stops, the body sends out other proteins to slowly break down the clot. Afterward, the fragments of D-dimer remain inside your blood. These fragments usually dissolve over time. However, if the blood clots do not dissolve after an injury heals, it can cause D-dimer levels to increase.

Q. What if my D-dimer test report shows high levels?

If your D-dimer test shows high levels, it may suggest that you might have a blood clot or blood clotting problems. Talk to your doctor about your test results. Your doctor may order imaging tests like Doppler ultrasound, and CT angiography to find out if you have a clotting disorder.

Q. What factors can affect my test results?

Your D-dimer levels may be higher in a few other health conditions such as infection, heart attack (myocardial infarction), liver disease, cancer, and injury.

Q. Can pregnancy affect D-Dimer levels?

Yes, pregnancy can cause an increase in D-Dimer levels, especially in the third trimester. This is a normal physiological response but makes interpreting D-Dimer levels more complex during pregnancy.

Q. What is deep vein thrombosis (DVT) and its symptoms?

DVT is a condition that occurs when a blood clot (thrombus) forms in one or more of the deep veins in the body, usually in the legs. Symptoms of DVT may include swelling, pain, tenderness, and red or discolored skin in the affected area, usually the legs.

Q. What is pulmonary embolism (PE) and its symptoms?

A pulmonary embolism (PE) is a blood clot that develops in a blood vessel, travels to the lungs, and stays there. Symptoms of PE can include shortness of breath, chest pain, cough, or coughing up blood.
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D-Dimer test price for other cities

Price inBangaloreRs. 1000
Price inMumbaiRs. 1000
Price inGurgaonRs. 400
Price inPuneRs. 1000
Price inThaneRs. 1000
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