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Cyfra (Ca) 21-1

Also referred as

Cyfra 21-1 Serum Assay

CYFRA 21.1 Blood Test

For men & women

Earliest reports in

216 hours

Contains

1 test

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The Cyfra (Ca) 21-1 test is a blood test that measures the level of cytokeratin 19 fragments, a protein released into the blood from damaged or cancerous lung cells. This test is primarily used as a tumor marker to help in the detection and monitoring of lung cancer, particularly non-small cell lung carcinoma (NSCLC).

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Blood

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Understanding Cyfra (Ca) 21-1

CYFRA 21-1 is a fragment of cytokeratin 19, a structural protein present in epithelial cells, including lung tissue. When lung cells are damaged or undergo malignant changes, fragments of cytokeratin 19 are released into the blood. Elevated CYFRA 21-1 levels may indicate the presence of lung cancer, especially non-small cell lung cancer, and can also help monitor response to treatment or detect recurrence after therapy. The Cyfra (Ca) 21-1 test measures the level of this protein fragment in the blood and is mainly used as a tumor marker for non-small cell lung cancer (NSCLC), including squamous cell carcinoma of the lung.

Doctors may recommend the CYFRA 21-1 test when there are symptoms suggestive of lung cancer, such as a persistent cough, chest pain, or difficulty breathing. It may also be advised for individuals at high risk of developing lung cancer due to factors like a history of smoking or occupational exposure. Additionally, the test is commonly used for patients who have already been diagnosed with lung cancer to monitor treatment effectiveness and detect any recurrence. Beyond lung cancer, CYFRA 21-1 can help evaluate other conditions that affect lung cancer biomarkers, providing valuable information for ongoing clinical assessment and management.

No special preparation is required for the Cyfra (Ca) 21-1 test. However, provide a brief clinical history at the time of sample collection. Inform a doctor about all the medications and supplements and underlying illnesses, as all these factors may affect the test results.

It is important to understand that CYFRA 21-1 alone cannot confirm a diagnosis of lung cancer and should be interpreted alongside other tests and clinical evaluations.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate, and always consult a doctor to understand the test results correctly.

Please note: This is an outsourced test. The sample is collected by TATA 1MG and processed at a NABL accredited partnered lab.

What does Cyfra (Ca) 21-1 measure?

The Cyfra (Ca) 21-1 test measures the level of a cytokeratin 19 fragment in the blood, a structural protein released when epithelial cells are damaged, injured, or grow abnormally. High levels are commonly seen in non-small cell lung cancer, particularly squamous cell carcinoma, and may also occur in other epithelial malignancies or some benign conditions affecting epithelial tissues.

Normal or low CYFRA 21-1 levels are generally not a cause for concern, but must be interpreted alongside clinical findings and other diagnostic tests. CYFRA 21-1 is not entirely specific to lung cancer; doctors typically use this test in combination with imaging studies and additional tumor markers to ensure an accurate diagnosis.

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FAQs related to Cyfra (Ca) 21-1

What is the Cyfra (Ca) 21-1 test?

It is a blood test that measures cytokeratin 19 fragments released from lung cells, often used as a tumor marker for lung cancer.

Who should take the Cyfra (Ca) 21-1 test?

People with symptoms of lung cancer, those diagnosed with non-small cell lung cancer, or patients under treatment to monitor therapy response.

How is the test done?

A small blood sample is drawn from a vein, usually in the arm, and sent to a lab for analysis.

Do I need to fast before the test?

No fasting is required for the Cyfra (Ca) 21-1 test.

Are there any risks in taking the test?

The test involves a simple blood draw and carries minimal risk, such as mild bruising or discomfort at the puncture site.

What do high CYFRA 21-1 levels indicate?

High levels may suggest non-small cell lung cancer, lung metastasis, or lung tissue damage from other conditions.

What do low CYFRA 21-1 levels indicate?

Low levels are usually normal and suggest the absence of significant lung cell damage or cancer.

Can CYFRA 21-1 detect all types of lung cancer?

No, it is most useful for non-small cell lung cancer and may not detect other types, such as small cell lung cancer.

How often should the test be repeated?

Frequency depends on the treatment plan, cancer stage, and the doctor’s recommendations for monitoring or follow-up.

What is non-small cell lung cancer (NSCLC)?

NSCLC is the most common type of lung cancer, accounting for about 85% of cases. It includes subtypes like squamous cell carcinoma and adenocarcinoma, which originate from epithelial cells in the lungs.

Who is at high risk for lung cancer?

People with a long-term history of smoking, exposure to secondhand smoke, occupational exposure to carcinogens like asbestos, or a family history of lung cancer are considered high risk.

Does CYFRA 21-1 rise in other conditions besides lung cancer?

Yes, elevated CYFRA 21-1 levels may also be seen in other epithelial cancers, such as bladder or head and neck cancers, and in some non-cancerous conditions affecting epithelial tissues.

How does Tata 1mg ensure accurate lab test results?

Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.

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